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Is lithium a neuroprotective agent?
Ann Clin Psychiatry. 2015 Feb; 27(1):49-54.AC

Abstract

BACKGROUND

Lithium was the first clinically effective mood stabilizer marketed worldwide. However, the medical literature suggests that lithium may have an indication as a neuroprotective agent.

METHODS

This review discusses the pharmacologic activity and potential effectiveness of lithium in the context of Alzheimer disease (AD) and Parkinson's disease (PD), the 2 most prominent neurodegenerative disorders in the United States. The toxicities of lithium, including lithium-induced extrapyramidal symptoms (LI-EPS) and cognitive impairments at therapeutic blood levels, are discussed. Cases that are thought to illustrate LI-EPS and cognitive impairments are critiqued.

RESULTS

Animal studies have shown positive results regarding the neuroprotective and antioxidant properties of lithium. Human studies indicate a potential benefit of lithium for improving cognition. Ongoing replicative studies are attempting to confirm the effectiveness and efficacy of lithium for treating patients diagnosed with AD or PD.

CONCLUSIONS

The available medical literature supports the conclusion that lithium should be considered as a research candidate medication for the treatment of neurologic diseases of dementias and PD.

Authors+Show Affiliations

Touro University California College of Pharmacy, Vallejo, California, USA. E-mail: paul.perry@tu.edu.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25696782

Citation

Vo, Thuy M., et al. "Is Lithium a Neuroprotective Agent?" Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists, vol. 27, no. 1, 2015, pp. 49-54.
Vo TM, Perry P, Ellerby M, et al. Is lithium a neuroprotective agent? Ann Clin Psychiatry. 2015;27(1):49-54.
Vo, T. M., Perry, P., Ellerby, M., & Bohnert, K. (2015). Is lithium a neuroprotective agent? Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists, 27(1), 49-54.
Vo TM, et al. Is Lithium a Neuroprotective Agent. Ann Clin Psychiatry. 2015;27(1):49-54. PubMed PMID: 25696782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is lithium a neuroprotective agent? AU - Vo,Thuy M, AU - Perry,Paul, AU - Ellerby,Michael, AU - Bohnert,Kimberly, PY - 2015/2/20/entrez PY - 2015/2/20/pubmed PY - 2015/12/15/medline SP - 49 EP - 54 JF - Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists JO - Ann Clin Psychiatry VL - 27 IS - 1 N2 - BACKGROUND: Lithium was the first clinically effective mood stabilizer marketed worldwide. However, the medical literature suggests that lithium may have an indication as a neuroprotective agent. METHODS: This review discusses the pharmacologic activity and potential effectiveness of lithium in the context of Alzheimer disease (AD) and Parkinson's disease (PD), the 2 most prominent neurodegenerative disorders in the United States. The toxicities of lithium, including lithium-induced extrapyramidal symptoms (LI-EPS) and cognitive impairments at therapeutic blood levels, are discussed. Cases that are thought to illustrate LI-EPS and cognitive impairments are critiqued. RESULTS: Animal studies have shown positive results regarding the neuroprotective and antioxidant properties of lithium. Human studies indicate a potential benefit of lithium for improving cognition. Ongoing replicative studies are attempting to confirm the effectiveness and efficacy of lithium for treating patients diagnosed with AD or PD. CONCLUSIONS: The available medical literature supports the conclusion that lithium should be considered as a research candidate medication for the treatment of neurologic diseases of dementias and PD. SN - 1547-3325 UR - https://www.unboundmedicine.com/medline/citation/25696782/Is_lithium_a_neuroprotective_agent L2 - https://www.aacp.com/article/abstract/is-lithium-a-neuroprotective-agent/ DB - PRIME DP - Unbound Medicine ER -