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Antioxidant properties of melatonin and its potential action in diseases.
Curr Top Med Chem. 2015; 15(9):894-903.CT

Abstract

In recent years, relationship between free radicals and oxidative stress with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear. Confirming the role of oxidants in numerous pathological conditions such as cancer, the antioxidants developed as therapeutics have been proven ineffective. It is well established that melatonin (MLT) and its metabolites are able to function as endogenous free-radical scavengers and broadspectrum antioxidants. Numerous studies also proved the role of MLT and its derivatives in many physiological processes and therapeutic functions, such as the regulation of circadian rhythm and immune functions. The aim of this review is to arouse attention to MLT as a potentially valuable agent in the prevention and/or treatment of some diseases.

Authors+Show Affiliations

Karaaslan C
Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, Turkey. cigdemka@gmail.com.
Suzen S
No affiliation info available

MeSH

AnimalsAnti-Inflammatory AgentsAntioxidantsClinical Trials as TopicDiabetes MellitusHumansMelatoninNeoplasmsNeurodegenerative DiseasesOxidative StressPsoriasisRadiation Injuries

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25697560

Citation

Karaaslan, Cigdem, and Sibel Suzen. "Antioxidant Properties of Melatonin and Its Potential Action in Diseases." Current Topics in Medicinal Chemistry, vol. 15, no. 9, 2015, pp. 894-903.
Karaaslan C, Suzen S. Antioxidant properties of melatonin and its potential action in diseases. Curr Top Med Chem. 2015;15(9):894-903.
Karaaslan, C., & Suzen, S. (2015). Antioxidant properties of melatonin and its potential action in diseases. Current Topics in Medicinal Chemistry, 15(9), 894-903.
Karaaslan C, Suzen S. Antioxidant Properties of Melatonin and Its Potential Action in Diseases. Curr Top Med Chem. 2015;15(9):894-903. PubMed PMID: 25697560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant properties of melatonin and its potential action in diseases. AU - Karaaslan,Cigdem, AU - Suzen,Sibel, PY - 2014/08/14/received PY - 2015/02/04/revised PY - 2015/02/05/accepted PY - 2015/2/21/entrez PY - 2015/2/24/pubmed PY - 2015/12/25/medline SP - 894 EP - 903 JF - Current topics in medicinal chemistry JO - Curr Top Med Chem VL - 15 IS - 9 N2 - In recent years, relationship between free radicals and oxidative stress with aging, cancer, atherosclerosis, neurodegenerative disorders, diabetes, and inflammatory diseases became increasingly clear. Confirming the role of oxidants in numerous pathological conditions such as cancer, the antioxidants developed as therapeutics have been proven ineffective. It is well established that melatonin (MLT) and its metabolites are able to function as endogenous free-radical scavengers and broadspectrum antioxidants. Numerous studies also proved the role of MLT and its derivatives in many physiological processes and therapeutic functions, such as the regulation of circadian rhythm and immune functions. The aim of this review is to arouse attention to MLT as a potentially valuable agent in the prevention and/or treatment of some diseases. SN - 1873-4294 UR - https://www.unboundmedicine.com/medline/citation/25697560/Antioxidant_properties_of_melatonin_and_its_potential_action_in_diseases_ DB - PRIME DP - Unbound Medicine ER -