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Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation.
Eur J Pharm Sci. 2015 Apr 25; 71:25-34.EJ

Abstract

Twin-screw granulation is a promising continuous alternative for traditional batchwise wet granulation processes. The twin-screw granulator (TSG) screws consist of transport and kneading element modules. Therefore, the granulation to a large extent is governed by the residence time distribution within each module where different granulation rate processes dominate over others. Currently, experimental data is used to determine the residence time distributions. In this study, a conceptual model based on classical chemical engineering methods is proposed to better understand and simulate the residence time distribution in a TSG. The experimental data were compared with the proposed most suitable conceptual model to estimate the parameters of the model and to analyse and predict the effects of changes in number of kneading discs and their stagger angle, screw speed and powder feed rate on residence time. The study established that the kneading block in the screw configuration acts as a plug-flow zone inside the granulator. Furthermore, it was found that a balance between the throughput force and conveying rate is required to obtain a good axial mixing inside the twin-screw granulator. Although the granulation behaviour is different for other excipients, the experimental data collection and modelling methods applied in this study are generic and can be adapted to other excipients.

Authors+Show Affiliations

BIOMATH, Department of Mathematical Modelling, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium; Laboratory of Pharmaceutical Process Analytical Technology, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium. Electronic address: ashish.kumar@ugent.be.Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium. Electronic address: jurgen.vercruysse@ugent.be.Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium. Electronic address: valerie.vanhoorne@ugent.be.Optical Measurement Technologies, VTT Technical Research Centre, Kuopio, Finland. Electronic address: maunu.toiviainen@vtt.fi.Optical Measurement Technologies, VTT Technical Research Centre, Kuopio, Finland. Electronic address: pierre-emmanuel.panouillot@vtt.fi.Optical Measurement Technologies, VTT Technical Research Centre, Kuopio, Finland. Electronic address: mikko.juuti@vtt.fi.Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium. Electronic address: chris.vervaet@ugent.be.Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium. Electronic address: jeanpaul.remon@ugent.be.CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark, 2800 Kongens Lyngby, Denmark. Electronic address: kvg@kt.dtu.dk.Laboratory of Pharmaceutical Process Analytical Technology, Department of Pharmaceutical Analysis, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium. Electronic address: thomas.debeer@ugent.be.BIOMATH, Department of Mathematical Modelling, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium. Electronic address: ingmar.nopens@ugent.be.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25698071

Citation

Kumar, Ashish, et al. "Conceptual Framework for Model-based Analysis of Residence Time Distribution in Twin-screw Granulation." European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, vol. 71, 2015, pp. 25-34.
Kumar A, Vercruysse J, Vanhoorne V, et al. Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation. Eur J Pharm Sci. 2015;71:25-34.
Kumar, A., Vercruysse, J., Vanhoorne, V., Toiviainen, M., Panouillot, P. E., Juuti, M., Vervaet, C., Remon, J. P., Gernaey, K. V., De Beer, T., & Nopens, I. (2015). Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 71, 25-34. https://doi.org/10.1016/j.ejps.2015.02.004
Kumar A, et al. Conceptual Framework for Model-based Analysis of Residence Time Distribution in Twin-screw Granulation. Eur J Pharm Sci. 2015 Apr 25;71:25-34. PubMed PMID: 25698071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation. AU - Kumar,Ashish, AU - Vercruysse,Jurgen, AU - Vanhoorne,Valérie, AU - Toiviainen,Maunu, AU - Panouillot,Pierre-Emmanuel, AU - Juuti,Mikko, AU - Vervaet,Chris, AU - Remon,Jean Paul, AU - Gernaey,Krist V, AU - De Beer,Thomas, AU - Nopens,Ingmar, Y1 - 2015/02/16/ PY - 2014/10/09/received PY - 2015/01/28/revised PY - 2015/02/08/accepted PY - 2015/2/21/entrez PY - 2015/2/24/pubmed PY - 2015/12/25/medline KW - Axial mixing KW - Flow modelling KW - Residence time distribution KW - Stagnant zone KW - Wet granulation SP - 25 EP - 34 JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences JO - Eur J Pharm Sci VL - 71 N2 - Twin-screw granulation is a promising continuous alternative for traditional batchwise wet granulation processes. The twin-screw granulator (TSG) screws consist of transport and kneading element modules. Therefore, the granulation to a large extent is governed by the residence time distribution within each module where different granulation rate processes dominate over others. Currently, experimental data is used to determine the residence time distributions. In this study, a conceptual model based on classical chemical engineering methods is proposed to better understand and simulate the residence time distribution in a TSG. The experimental data were compared with the proposed most suitable conceptual model to estimate the parameters of the model and to analyse and predict the effects of changes in number of kneading discs and their stagger angle, screw speed and powder feed rate on residence time. The study established that the kneading block in the screw configuration acts as a plug-flow zone inside the granulator. Furthermore, it was found that a balance between the throughput force and conveying rate is required to obtain a good axial mixing inside the twin-screw granulator. Although the granulation behaviour is different for other excipients, the experimental data collection and modelling methods applied in this study are generic and can be adapted to other excipients. SN - 1879-0720 UR - https://www.unboundmedicine.com/medline/citation/25698071/Conceptual_framework_for_model_based_analysis_of_residence_time_distribution_in_twin_screw_granulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-0987(15)00054-8 DB - PRIME DP - Unbound Medicine ER -