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Low-lipid diet reduces frequency and severity of acute migraine attacks.

Abstract

BACKGROUND AND AIM

There is uncertainty regarding the prevention of migraine crises by changing the lifestyle of patients. The aim of this randomized, crossover intervention trial was to evaluate the effects of a low lipid intake on the incidence and severity of migraine crises, in comparison to a diet with moderate lipid intake.

METHODS AND RESULTS

After a 2-month run-in when patients received preventive medication but were left on their habitual diet, a low-lipid or a normal-lipid diet was randomly prescribed for 3 months and thereafter diets were crossed over for the following 3 months. Headache was diagnosed based on the International Classification of Headache Disorders (IHCD) III criteria. The number and severity of attacks were assessed using a self-reported calendar. Adherence to the diet was assessed by a food frequency questionnaire. An analysis was performed on the 83 episodic or chronic migraineurs (63 female and 20 male), in the age range of 18-57 years, who completed both intervention periods. Obese subjects had a significantly higher number of attacks than those overweight or with normal body weight (24.7 ± 8, 16.3 ± 12, and 15.6 ± 11, respectively, p < 0.03) with a significant relationship between the body mass index (BMI) and the number of monthly attacks (r = 0.238, p < 0.03). The number (2.9 ± 3.7 vs. 6.8 ± 7.5, p < 0.001) and severity (1.2 + 0.9 vs. 1.7 ± 0.9, p < 0.01) of attacks significantly decreased during both intervention periods, with a significant difference in favour of the low-lipid diet.

CONCLUSIONS

In this group of patients, the low-lipid diet significantly affected the number and severity of migraine attacks in comparison to a normal-lipid diet. ClinicalTrials.gov Identifier: NCT 01917474.

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  • Authors+Show Affiliations

    ,

    Department of Medicine and Surgery, Federico 2nd University of Naples, Via S. Pansini 5, 80131 Naples, Italy. Electronic address: ferrara@unina.it.

    ,

    Department of Medicine and Surgery, Federico 2nd University of Naples, Via S. Pansini 5, 80131 Naples, Italy.

    ,

    Department of Medicine and Surgery, Federico 2nd University of Naples, Via S. Pansini 5, 80131 Naples, Italy.

    ,

    Department of Medicine and Surgery, Federico 2nd University of Naples, Via S. Pansini 5, 80131 Naples, Italy.

    ,

    Department of Medicine and Surgery, Federico 2nd University of Naples, Via S. Pansini 5, 80131 Naples, Italy.

    ,

    Department of Medicine and Surgery, Federico 2nd University of Naples, Via S. Pansini 5, 80131 Naples, Italy.

    ,

    Department of Medicine and Surgery, Federico 2nd University of Naples, Via S. Pansini 5, 80131 Naples, Italy.

    Department of Medicine and Surgery, Federico 2nd University of Naples, Via S. Pansini 5, 80131 Naples, Italy.

    Source

    MeSH

    Adolescent
    Adult
    Blood Pressure
    Body Mass Index
    Body Weight
    Cross-Over Studies
    Diet, Fat-Restricted
    Dietary Fats
    Energy Intake
    Fatty Acids
    Fatty Acids, Monounsaturated
    Feeding Behavior
    Female
    Humans
    Life Style
    Male
    Middle Aged
    Migraine Disorders
    Nutritional Status
    Obesity
    Olive Oil
    Young Adult

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial

    Language

    eng

    PubMed ID

    25698152

    Citation

    Ferrara, L A., et al. "Low-lipid Diet Reduces Frequency and Severity of Acute Migraine Attacks." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 25, no. 4, 2015, pp. 370-5.
    Ferrara LA, Pacioni D, Di Fronzo V, et al. Low-lipid diet reduces frequency and severity of acute migraine attacks. Nutr Metab Cardiovasc Dis. 2015;25(4):370-5.
    Ferrara, L. A., Pacioni, D., Di Fronzo, V., Russo, B. F., Speranza, E., Carlino, V., ... Ferrara, F. (2015). Low-lipid diet reduces frequency and severity of acute migraine attacks. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 25(4), pp. 370-5. doi:10.1016/j.numecd.2014.12.006.
    Ferrara LA, et al. Low-lipid Diet Reduces Frequency and Severity of Acute Migraine Attacks. Nutr Metab Cardiovasc Dis. 2015;25(4):370-5. PubMed PMID: 25698152.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Low-lipid diet reduces frequency and severity of acute migraine attacks. AU - Ferrara,L A, AU - Pacioni,D, AU - Di Fronzo,V, AU - Russo,B F, AU - Speranza,E, AU - Carlino,V, AU - Gargiulo,F, AU - Ferrara,F, Y1 - 2014/12/27/ PY - 2014/09/11/received PY - 2014/12/17/revised PY - 2014/12/17/accepted PY - 2015/2/21/entrez PY - 2015/2/24/pubmed PY - 2016/1/12/medline KW - Headache KW - Low-lipid diet KW - Moderate dietary fat restriction SP - 370 EP - 5 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 25 IS - 4 N2 - BACKGROUND AND AIM: There is uncertainty regarding the prevention of migraine crises by changing the lifestyle of patients. The aim of this randomized, crossover intervention trial was to evaluate the effects of a low lipid intake on the incidence and severity of migraine crises, in comparison to a diet with moderate lipid intake. METHODS AND RESULTS: After a 2-month run-in when patients received preventive medication but were left on their habitual diet, a low-lipid or a normal-lipid diet was randomly prescribed for 3 months and thereafter diets were crossed over for the following 3 months. Headache was diagnosed based on the International Classification of Headache Disorders (IHCD) III criteria. The number and severity of attacks were assessed using a self-reported calendar. Adherence to the diet was assessed by a food frequency questionnaire. An analysis was performed on the 83 episodic or chronic migraineurs (63 female and 20 male), in the age range of 18-57 years, who completed both intervention periods. Obese subjects had a significantly higher number of attacks than those overweight or with normal body weight (24.7 ± 8, 16.3 ± 12, and 15.6 ± 11, respectively, p < 0.03) with a significant relationship between the body mass index (BMI) and the number of monthly attacks (r = 0.238, p < 0.03). The number (2.9 ± 3.7 vs. 6.8 ± 7.5, p < 0.001) and severity (1.2 + 0.9 vs. 1.7 ± 0.9, p < 0.01) of attacks significantly decreased during both intervention periods, with a significant difference in favour of the low-lipid diet. CONCLUSIONS: In this group of patients, the low-lipid diet significantly affected the number and severity of migraine attacks in comparison to a normal-lipid diet. ClinicalTrials.gov Identifier: NCT 01917474. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/25698152/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(14)00371-8 DB - PRIME DP - Unbound Medicine ER -