Tags

Type your tag names separated by a space and hit enter

Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats.
Clin Med Insights Cardiol. 2015; 9(Suppl 1):1-9.CM

Abstract

A baroreflex equilibrium diagram describes the relation between input pressure and sympathetic nerve activity (SNA) and that between SNA and arterial pressure (AP). To calibrate the SNA axis (abscissa) of the baroreflex equilibrium diagram, the AP response to intravenous bolus injections of phenylephrine (0.2-50 μg/kg) or norepinephrine (NE, 0.02-5 μg/kg) was examined in normal control rats (NC, n = 9) and rats with chronic heart failure (CHF, n = 6). The maximum slope of the dose-effect curve was significantly smaller in the CHF group than in the NC group (57.3 ± 5.2 vs 80.9 ± 6.3 mmHg/decade for phenylephrine, 60.2 ± 7.8 vs 80.4 ± 5.9 mmHg/decade for NE; P < 0.01). The CHF/NC ratio of the maximum slope was used to calibrate SNA. While the calibrated baroreflex equilibrium diagram showed increased maximum SNA and operating-point SNA in CHF rats compared with NC rats, the magnitude of increase was smaller than that expected from the excess plasma NE concentration in CHF rats. Plasma NE concentration in the CHF group could be disproportionally high relative to SNA.

Authors+Show Affiliations

Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan. ; Department of Artificial Organ Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan. ; Department of Artificial Organ Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25698884

Citation

Kawada, Toru, et al. "Calibration of Baroreflex Equilibrium Diagram Based On Exogenous Pressor Agents in Chronic Heart Failure Rats." Clinical Medicine Insights. Cardiology, vol. 9, no. Suppl 1, 2015, pp. 1-9.
Kawada T, Li M, Sata Y, et al. Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats. Clinical Medicine Insights. Cardiology. 2015;9(Suppl 1):1-9.
Kawada, T., Li, M., Sata, Y., Zheng, C., Turner, M. J., Shimizu, S., & Sugimachi, M. (2015). Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats. Clinical Medicine Insights. Cardiology, 9(Suppl 1), 1-9. https://doi.org/10.4137/CMC.S18759
Kawada T, et al. Calibration of Baroreflex Equilibrium Diagram Based On Exogenous Pressor Agents in Chronic Heart Failure Rats. Clinical Medicine Insights. Cardiology. 2015;9(Suppl 1):1-9. PubMed PMID: 25698884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calibration of baroreflex equilibrium diagram based on exogenous pressor agents in chronic heart failure rats. AU - Kawada,Toru, AU - Li,Meihua, AU - Sata,Yusuke, AU - Zheng,Can, AU - Turner,Michael J, AU - Shimizu,Shuji, AU - Sugimachi,Masaru, Y1 - 2015/02/03/ PY - 2014/10/08/received PY - 2014/12/15/revised PY - 2014/12/26/accepted PY - 2015/2/21/entrez PY - 2015/2/24/pubmed PY - 2015/2/24/medline KW - arterial pressure KW - carotid sinus baroreflex KW - norepinephrine KW - open-loop analysis KW - phenylephrine SP - 1 EP - 9 JF - Clinical Medicine Insights. Cardiology VL - 9 IS - Suppl 1 N2 - A baroreflex equilibrium diagram describes the relation between input pressure and sympathetic nerve activity (SNA) and that between SNA and arterial pressure (AP). To calibrate the SNA axis (abscissa) of the baroreflex equilibrium diagram, the AP response to intravenous bolus injections of phenylephrine (0.2-50 μg/kg) or norepinephrine (NE, 0.02-5 μg/kg) was examined in normal control rats (NC, n = 9) and rats with chronic heart failure (CHF, n = 6). The maximum slope of the dose-effect curve was significantly smaller in the CHF group than in the NC group (57.3 ± 5.2 vs 80.9 ± 6.3 mmHg/decade for phenylephrine, 60.2 ± 7.8 vs 80.4 ± 5.9 mmHg/decade for NE; P < 0.01). The CHF/NC ratio of the maximum slope was used to calibrate SNA. While the calibrated baroreflex equilibrium diagram showed increased maximum SNA and operating-point SNA in CHF rats compared with NC rats, the magnitude of increase was smaller than that expected from the excess plasma NE concentration in CHF rats. Plasma NE concentration in the CHF group could be disproportionally high relative to SNA. SN - 1179-5468 UR - https://www.unboundmedicine.com/medline/citation/25698884/Calibration_of_baroreflex_equilibrium_diagram_based_on_exogenous_pressor_agents_in_chronic_heart_failure_rats_ L2 - https://journals.sagepub.com/doi/10.4137/CMC.S18759?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.