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Somatostatin concentration and binding in the rat hypothalamus and striatum during severe insulin-induced hypoglycemia.
Biosci Rep. 1989 Apr; 9(2):199-206.BR

Abstract

Hypoglycemia was induced by administration of insulin (40 I.U./kg) to 24 h fasted rats. Somatostatin-like immunoreactivity (SLI) and 125I-Tyr11-somatostatin binding were measured in the striatum and hypothalamus at the onset of hypoglycemic coma (5-10 min). No significant changes in SLI concentration were detected in either site although the total number of specific somatostatin receptors in the striatum membranes, but not in the hypothalamus, decreased in insulin-injected rats when compared with the control group.

Authors+Show Affiliations

Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Madrid, Spain.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2569898

Citation

Rodriguez-Sanchez, M N., and E Arilla. "Somatostatin Concentration and Binding in the Rat Hypothalamus and Striatum During Severe Insulin-induced Hypoglycemia." Bioscience Reports, vol. 9, no. 2, 1989, pp. 199-206.
Rodriguez-Sanchez MN, Arilla E. Somatostatin concentration and binding in the rat hypothalamus and striatum during severe insulin-induced hypoglycemia. Biosci Rep. 1989;9(2):199-206.
Rodriguez-Sanchez, M. N., & Arilla, E. (1989). Somatostatin concentration and binding in the rat hypothalamus and striatum during severe insulin-induced hypoglycemia. Bioscience Reports, 9(2), 199-206.
Rodriguez-Sanchez MN, Arilla E. Somatostatin Concentration and Binding in the Rat Hypothalamus and Striatum During Severe Insulin-induced Hypoglycemia. Biosci Rep. 1989;9(2):199-206. PubMed PMID: 2569898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatostatin concentration and binding in the rat hypothalamus and striatum during severe insulin-induced hypoglycemia. AU - Rodriguez-Sanchez,M N, AU - Arilla,E, PY - 1989/4/1/pubmed PY - 1989/4/1/medline PY - 1989/4/1/entrez SP - 199 EP - 206 JF - Bioscience reports JO - Biosci Rep VL - 9 IS - 2 N2 - Hypoglycemia was induced by administration of insulin (40 I.U./kg) to 24 h fasted rats. Somatostatin-like immunoreactivity (SLI) and 125I-Tyr11-somatostatin binding were measured in the striatum and hypothalamus at the onset of hypoglycemic coma (5-10 min). No significant changes in SLI concentration were detected in either site although the total number of specific somatostatin receptors in the striatum membranes, but not in the hypothalamus, decreased in insulin-injected rats when compared with the control group. SN - 0144-8463 UR - https://www.unboundmedicine.com/medline/citation/2569898/Somatostatin_concentration_and_binding_in_the_rat_hypothalamus_and_striatum_during_severe_insulin_induced_hypoglycemia_ DB - PRIME DP - Unbound Medicine ER -