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Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus.
Brain Res. 1989 Aug 07; 494(1):36-41.BR

Abstract

The effects of severe insulin-induced hypoglycemia on somatostatin level and specific binding in the cerebral cortex and hippocampus were examined using 125I-Tyr11-somatostatin as a ligand. Severe insulin-induced hypoglycemia did not affect the level of somatostatin-like immunoreactivity in the brain areas studied. However, the number (but not the affinity) of specific somatostatin receptors was significantly decreased in membrane preparation from the hippocampus but not in the cerebral cortex at the onset of hypoglycemic coma (5-10 min). Administration of glucose at the onset of hypoglycemic coma brought about extensive recovery of hippocampal somatostatin receptor number. These results suggest that glucose modulates the somatostatin receptor in the rat hippocampus. The physiological significance of these findings remains to be clarified.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcalá de Henares, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2569918

Citation

Rodriguez-Sanchez, M N., et al. "Effects of Insulin-induced Hypoglycemia On Somatostatin Level and Binding in Rat Cerebral Cortex and Hippocampus." Brain Research, vol. 494, no. 1, 1989, pp. 36-41.
Rodriguez-Sanchez MN, Colas B, Prieto JC, et al. Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus. Brain Res. 1989;494(1):36-41.
Rodriguez-Sanchez, M. N., Colas, B., Prieto, J. C., & Arilla, E. (1989). Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus. Brain Research, 494(1), 36-41.
Rodriguez-Sanchez MN, et al. Effects of Insulin-induced Hypoglycemia On Somatostatin Level and Binding in Rat Cerebral Cortex and Hippocampus. Brain Res. 1989 Aug 7;494(1):36-41. PubMed PMID: 2569918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus. AU - Rodriguez-Sanchez,M N, AU - Colas,B, AU - Prieto,J C, AU - Arilla,E, PY - 1989/8/7/pubmed PY - 1989/8/7/medline PY - 1989/8/7/entrez SP - 36 EP - 41 JF - Brain research JO - Brain Res VL - 494 IS - 1 N2 - The effects of severe insulin-induced hypoglycemia on somatostatin level and specific binding in the cerebral cortex and hippocampus were examined using 125I-Tyr11-somatostatin as a ligand. Severe insulin-induced hypoglycemia did not affect the level of somatostatin-like immunoreactivity in the brain areas studied. However, the number (but not the affinity) of specific somatostatin receptors was significantly decreased in membrane preparation from the hippocampus but not in the cerebral cortex at the onset of hypoglycemic coma (5-10 min). Administration of glucose at the onset of hypoglycemic coma brought about extensive recovery of hippocampal somatostatin receptor number. These results suggest that glucose modulates the somatostatin receptor in the rat hippocampus. The physiological significance of these findings remains to be clarified. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/2569918/Effects_of_insulin_induced_hypoglycemia_on_somatostatin_level_and_binding_in_rat_cerebral_cortex_and_hippocampus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-8993(89)90141-8 DB - PRIME DP - Unbound Medicine ER -