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Sex differences in serum leptin and its relation to markers of cardiometabolic risk in middle-aged adults: evidence from a population-based study.
Nutrition. 2015 Mar; 31(3):491-7.N

Abstract

OBJECTIVE

At elevated concentrations, circulating leptin has been associated with metabolic disturbances, namely insulin resistance, elevated blood pressure, inflammation, and endothelial dysfunction. Because women have higher leptin concentrations than men, it is possible that the effects of leptin on the metabolic profile are different between the sexes. The aim of this study was to investigate whether leptin is one of the key hormones to sex affect differences in the pathophysiology of cardiometabolic risk.

METHODS

Participants were 178 men and 284 women (average age: 53.9 y), evaluated in a cross-sectional, population-based study performed in Brazil. A structural equation model was used to test a theoretic pathway for the relationship between serum leptin, obesity indicators (body weight and waist circumference), and cardiometabolic risk factors (high-sensitivity C-reactive protein; blood pressure; atherogenic dyslipidemia-total cholesterol/high-density lipoprotein cholesterol (HDL-C) ratio and triacylglycerol /HDL-C ratio; and fasting plasma glucose) stratified by sex.

RESULTS

In men, increasing 1 SD in serum leptin predicted an increase in 0.731 SD in body weight and in 0.123 SD in C-reactive protein. Serum leptin had positive and significant indirect effects on men's ratios of total cholesterol to HDL-C (β = 0.215) and triacylglycerol to HDL-C (β = 0.209), as well as fasting glucose (β = 0.173). In women, serum leptin predicted an increase of 0.675 SD in body weight and had positive indirect effects on all cardiometabolic risk factors evaluated.

CONCLUSIONS

Serum leptin was indirectly related to cardiometabolic risk factors and its relation was modest and different between sexes. The effects of leptin through mediation of body weight and waist circumference highlight the importance of weight control to prevent cardiometabolic disorders in middle-aged adults.

Authors+Show Affiliations

Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil. Electronic address: michelle.castro@usp.br.Department of Epidemiology and Biostatistics, Fluminense Federal University, Niteroi, RJ, Brazil.Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.Department of Nutrition, School of Public Health, University of São Paulo, São Paulo, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25701340

Citation

de Castro, Michelle Alessandra, et al. "Sex Differences in Serum Leptin and Its Relation to Markers of Cardiometabolic Risk in Middle-aged Adults: Evidence From a Population-based Study." Nutrition (Burbank, Los Angeles County, Calif.), vol. 31, no. 3, 2015, pp. 491-7.
de Castro MA, Baltar VT, Marchioni DM, et al. Sex differences in serum leptin and its relation to markers of cardiometabolic risk in middle-aged adults: evidence from a population-based study. Nutrition. 2015;31(3):491-7.
de Castro, M. A., Baltar, V. T., Marchioni, D. M., & Fisberg, R. M. (2015). Sex differences in serum leptin and its relation to markers of cardiometabolic risk in middle-aged adults: evidence from a population-based study. Nutrition (Burbank, Los Angeles County, Calif.), 31(3), 491-7. https://doi.org/10.1016/j.nut.2014.09.007
de Castro MA, et al. Sex Differences in Serum Leptin and Its Relation to Markers of Cardiometabolic Risk in Middle-aged Adults: Evidence From a Population-based Study. Nutrition. 2015;31(3):491-7. PubMed PMID: 25701340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex differences in serum leptin and its relation to markers of cardiometabolic risk in middle-aged adults: evidence from a population-based study. AU - de Castro,Michelle Alessandra, AU - Baltar,Valéria Troncoso, AU - Marchioni,Dirce Maria Lobo, AU - Fisberg,Regina Mara, Y1 - 2014/10/13/ PY - 2014/06/21/received PY - 2014/08/16/revised PY - 2014/09/07/accepted PY - 2015/2/22/entrez PY - 2015/2/24/pubmed PY - 2015/12/29/medline KW - Adults KW - Cardiometabolic risk factors KW - Cross-sectional study KW - Leptin KW - Obesity KW - Structural equation model SP - 491 EP - 7 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 31 IS - 3 N2 - OBJECTIVE: At elevated concentrations, circulating leptin has been associated with metabolic disturbances, namely insulin resistance, elevated blood pressure, inflammation, and endothelial dysfunction. Because women have higher leptin concentrations than men, it is possible that the effects of leptin on the metabolic profile are different between the sexes. The aim of this study was to investigate whether leptin is one of the key hormones to sex affect differences in the pathophysiology of cardiometabolic risk. METHODS: Participants were 178 men and 284 women (average age: 53.9 y), evaluated in a cross-sectional, population-based study performed in Brazil. A structural equation model was used to test a theoretic pathway for the relationship between serum leptin, obesity indicators (body weight and waist circumference), and cardiometabolic risk factors (high-sensitivity C-reactive protein; blood pressure; atherogenic dyslipidemia-total cholesterol/high-density lipoprotein cholesterol (HDL-C) ratio and triacylglycerol /HDL-C ratio; and fasting plasma glucose) stratified by sex. RESULTS: In men, increasing 1 SD in serum leptin predicted an increase in 0.731 SD in body weight and in 0.123 SD in C-reactive protein. Serum leptin had positive and significant indirect effects on men's ratios of total cholesterol to HDL-C (β = 0.215) and triacylglycerol to HDL-C (β = 0.209), as well as fasting glucose (β = 0.173). In women, serum leptin predicted an increase of 0.675 SD in body weight and had positive indirect effects on all cardiometabolic risk factors evaluated. CONCLUSIONS: Serum leptin was indirectly related to cardiometabolic risk factors and its relation was modest and different between sexes. The effects of leptin through mediation of body weight and waist circumference highlight the importance of weight control to prevent cardiometabolic disorders in middle-aged adults. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/25701340/Sex_differences_in_serum_leptin_and_its_relation_to_markers_of_cardiometabolic_risk_in_middle_aged_adults:_evidence_from_a_population_based_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(14)00428-6 DB - PRIME DP - Unbound Medicine ER -