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Traumatic brain injury and late-life dementia.

Abstract

Little is known of the impact of traumatic brain injury (TBI) on outcomes decades later when the effects of the injury interact with the aging brain. Some, but not all, epidemiologic studies have reported an association between TBI and increased risk of Alzheimer's disease (AD) and other neurodegenerative disorders years after the injury. There is evidence that this association has a dose-response pattern such that risk of dementia progressively increases as the number and severity of head injuries increase. Some studies have shown that one of the mechanisms underlying the association is that TBI may contribute to earlier onset of dementia. The APOE ϵ4 allele has been proposed as a biological link between TBI and AD because individuals with an APOE ϵ4 allele show typical AD pathology within a short period postinjury and are at increased risk of poorer cognitive outcomes. There are also likely other, yet to be identified factors that interact with the postinjury damage and aging-related brain changes leading to exacerbated cognitive decline and dementia. Given the large number of young individuals with military, sports-related, and other causes of head injuries, there is a window of opportunity and an urgency to understand the link between TBI and dementia before these TBI survivors reach the age of risk for dementia.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. Electronic address: brenda.plassman@duke.edu.

    Department of Physical Medicine and Rehabilitation; Department of Psychiatry and Behavioral Sciences; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Medical School and Department of Psychology, Northwestern University, Chicago, IL, USA.

    Source

    Handbook of clinical neurology 128: 2015 pg 711-22

    MeSH

    Aging
    Brain Injuries
    Dementia
    Disease Progression
    Humans
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    25701916

    Citation

    Plassman, Brenda L., and Jordan Grafman. "Traumatic Brain Injury and Late-life Dementia." Handbook of Clinical Neurology, vol. 128, 2015, pp. 711-22.
    Plassman BL, Grafman J. Traumatic brain injury and late-life dementia. Handb Clin Neurol. 2015;128:711-22.
    Plassman, B. L., & Grafman, J. (2015). Traumatic brain injury and late-life dementia. Handbook of Clinical Neurology, 128, pp. 711-22. doi:10.1016/B978-0-444-63521-1.00044-3.
    Plassman BL, Grafman J. Traumatic Brain Injury and Late-life Dementia. Handb Clin Neurol. 2015;128:711-22. PubMed PMID: 25701916.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Traumatic brain injury and late-life dementia. AU - Plassman,Brenda L, AU - Grafman,Jordan, PY - 2015/2/23/entrez PY - 2015/2/24/pubmed PY - 2016/8/16/medline KW - Alzheimer's disease KW - dementia KW - head injury KW - risk factors for dementia KW - traumatic brain injury SP - 711 EP - 22 JF - Handbook of clinical neurology JO - Handb Clin Neurol VL - 128 N2 - Little is known of the impact of traumatic brain injury (TBI) on outcomes decades later when the effects of the injury interact with the aging brain. Some, but not all, epidemiologic studies have reported an association between TBI and increased risk of Alzheimer's disease (AD) and other neurodegenerative disorders years after the injury. There is evidence that this association has a dose-response pattern such that risk of dementia progressively increases as the number and severity of head injuries increase. Some studies have shown that one of the mechanisms underlying the association is that TBI may contribute to earlier onset of dementia. The APOE ϵ4 allele has been proposed as a biological link between TBI and AD because individuals with an APOE ϵ4 allele show typical AD pathology within a short period postinjury and are at increased risk of poorer cognitive outcomes. There are also likely other, yet to be identified factors that interact with the postinjury damage and aging-related brain changes leading to exacerbated cognitive decline and dementia. Given the large number of young individuals with military, sports-related, and other causes of head injuries, there is a window of opportunity and an urgency to understand the link between TBI and dementia before these TBI survivors reach the age of risk for dementia. SN - 0072-9752 UR - https://www.unboundmedicine.com/medline/citation/25701916/Traumatic_brain_injury_and_late_life_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/B978-0-444-63521-1.00044-3 DB - PRIME DP - Unbound Medicine ER -