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Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies.
Wound Repair Regen 2015 Mar-Apr; 23(2):197-202WR

Abstract

The wound healing promoting effect of negative wound pressure therapies (NPWT) takes place at the wound interface. The use of bioactive substances at this site represents a major research area for the development of future NPWT therapies. To assess wound healing kinetics in pressure ulcers treated by NPWT with or without the use of a thin interface membrane consisting of poly-N-acetyl glucosamine nanofibers (sNAG) a prospective randomized clinical trial was performed. The safety of the combination of NPWT and sNAG was also assessed in patients treated with antiplatelet drugs. In the performed study, the combination of NPWT and sNAG in 10 patients compared to NPWT alone in 10 patients promoted wound healing due to an improved contraction of the wound margins (p = 0.05) without a change in wound epithelization. In 6 patients treated with antiplatelet drugs no increased wound bleeding was observed in patients treated by NPWT and sNAG. In conclusion, the application of thin membranes of sNAG nanofibers at the wound interface using NPWT was safe and augmented the action of NPWT leading to improved wound healing due to a stimulation of wound contraction.

Authors+Show Affiliations

Division of Plastic and Reconstructive Surgery, University Hospital of Basel, Basel, Switzerland.Division of Plastic and Reconstructive Surgery, University Hospital of Basel, Basel, Switzerland. Division of Plastic and Reconstructive Surgery, University Hospital of Lausanne, Lausanne, Switzerland.Naval Blood Research Laboratory, Boston, Massachusetts.Marine Polymer Technologies Inc., Danvers, Massachusetts.Division of Plastic and Reconstructive Surgery, University Hospital of Basel, Basel, Switzerland.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25703411

Citation

Fulco, Ilario, et al. "Poly-N-acetyl Glucosamine Nanofibers for Negative-pressure Wound Therapies." Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society, vol. 23, no. 2, 2015, pp. 197-202.
Fulco I, Erba P, Valeri RC, et al. Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies. Wound Repair Regen. 2015;23(2):197-202.
Fulco, I., Erba, P., Valeri, R. C., Vournakis, J., & Schaefer, D. J. (2015). Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society, 23(2), pp. 197-202. doi:10.1111/wrr.12273.
Fulco I, et al. Poly-N-acetyl Glucosamine Nanofibers for Negative-pressure Wound Therapies. Wound Repair Regen. 2015;23(2):197-202. PubMed PMID: 25703411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Poly-N-acetyl glucosamine nanofibers for negative-pressure wound therapies. AU - Fulco,Ilario, AU - Erba,Paolo, AU - Valeri,Robert C, AU - Vournakis,John, AU - Schaefer,Dirk J, PY - 2014/12/12/received PY - 2015/02/12/revised PY - 2015/02/17/accepted PY - 2015/2/24/entrez PY - 2015/2/24/pubmed PY - 2016/5/11/medline SP - 197 EP - 202 JF - Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society JO - Wound Repair Regen VL - 23 IS - 2 N2 - The wound healing promoting effect of negative wound pressure therapies (NPWT) takes place at the wound interface. The use of bioactive substances at this site represents a major research area for the development of future NPWT therapies. To assess wound healing kinetics in pressure ulcers treated by NPWT with or without the use of a thin interface membrane consisting of poly-N-acetyl glucosamine nanofibers (sNAG) a prospective randomized clinical trial was performed. The safety of the combination of NPWT and sNAG was also assessed in patients treated with antiplatelet drugs. In the performed study, the combination of NPWT and sNAG in 10 patients compared to NPWT alone in 10 patients promoted wound healing due to an improved contraction of the wound margins (p = 0.05) without a change in wound epithelization. In 6 patients treated with antiplatelet drugs no increased wound bleeding was observed in patients treated by NPWT and sNAG. In conclusion, the application of thin membranes of sNAG nanofibers at the wound interface using NPWT was safe and augmented the action of NPWT leading to improved wound healing due to a stimulation of wound contraction. SN - 1524-475X UR - https://www.unboundmedicine.com/medline/citation/25703411/Poly_N_acetyl_glucosamine_nanofibers_for_negative_pressure_wound_therapies_ L2 - https://doi.org/10.1111/wrr.12273 DB - PRIME DP - Unbound Medicine ER -