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Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes.
Biochem Biophys Res Commun. 1989 Aug 30; 163(1):348-55.BB

Abstract

The first and rate limiting step in the conversion of linoleic and alpha-linolenic acid is catalyzed by the delta - 6 - desaturase (D6D) enzyme. Rat liver microsomal D6D activity decreases on linolenic acid at a rate proportional to the animal age; on alpha-linolenic acid the decrease in D6D activity begins only later than on linoleic acid. The fatty acid composition of liver microsomes determined by gas chromatographic analysis confirms the impairment of the enzymatic activity directly measured. Our data indicate a correlation between aging and D6D activity impairment. The loss of D6D activity may be a key factor in aging through altering the eicosanoid balance.

Authors+Show Affiliations

Dipartimento di Biochimica, University of Bologna, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2570573

Citation

Hrelia, S, et al. "Age-related Changes in Linoleate and Alpha-linolenate Desaturation By Rat Liver Microsomes." Biochemical and Biophysical Research Communications, vol. 163, no. 1, 1989, pp. 348-55.
Hrelia S, Bordoni A, Celadon M, et al. Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. Biochem Biophys Res Commun. 1989;163(1):348-55.
Hrelia, S., Bordoni, A., Celadon, M., Turchetto, E., Biagi, P. L., & Rossi, C. A. (1989). Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. Biochemical and Biophysical Research Communications, 163(1), 348-55.
Hrelia S, et al. Age-related Changes in Linoleate and Alpha-linolenate Desaturation By Rat Liver Microsomes. Biochem Biophys Res Commun. 1989 Aug 30;163(1):348-55. PubMed PMID: 2570573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related changes in linoleate and alpha-linolenate desaturation by rat liver microsomes. AU - Hrelia,S, AU - Bordoni,A, AU - Celadon,M, AU - Turchetto,E, AU - Biagi,P L, AU - Rossi,C A, PY - 1989/8/30/pubmed PY - 1989/8/30/medline PY - 1989/8/30/entrez SP - 348 EP - 55 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 163 IS - 1 N2 - The first and rate limiting step in the conversion of linoleic and alpha-linolenic acid is catalyzed by the delta - 6 - desaturase (D6D) enzyme. Rat liver microsomal D6D activity decreases on linolenic acid at a rate proportional to the animal age; on alpha-linolenic acid the decrease in D6D activity begins only later than on linoleic acid. The fatty acid composition of liver microsomes determined by gas chromatographic analysis confirms the impairment of the enzymatic activity directly measured. Our data indicate a correlation between aging and D6D activity impairment. The loss of D6D activity may be a key factor in aging through altering the eicosanoid balance. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/2570573/Age_related_changes_in_linoleate_and_alpha_linolenate_desaturation_by_rat_liver_microsomes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0006-291X(89)92142-6 DB - PRIME DP - Unbound Medicine ER -