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Effect of maprotiline combined with conventional neuroleptics against negative symptoms of chronic schizophrenia.
Drugs Exp Clin Res. 1989; 15(4):171-6.DE

Abstract

The therapeutic efficacy and target symptoms of maprotiline were tested by administering it in addition to conventional neuroleptic treatment for 10 weeks to a total of 32 chronic schizophrenic patients who showed no, or only partial, response to the neuroleptic medication. The final global improvement rating was 68.8% for all patients. Average therapeutic doses administered were 150 mg per day. Changes in psychotic symptoms were assessed by the Brief Psychiatric Rating Scale (BPRS), Psychiatric Evaluating scale (PES), and the Scale for the Assessment of Negative Symptoms (SANS). All mean improvement rates of these rating scales were observed at the 2nd week after the start of treatment, and maprotiline produced a marked amelioration in negative symptoms such as decreased spontaneity, blunted affect, emotional withdrawal, impaired work or recreation, etc. The incidence of side-effects was 37.5%. Constipation was the most frequently occurring side-effect. Neither side-effects nor laboratory test results were serious enough to discontinue the trial, except in the case of one chronic patient who showed acute exacerbation of symptoms due to maprotiline-induced insomnia, elation and hallucination. These results suggest that maprotiline improves the negative symptoms of schizophrenia by a noradrenaline potentiating action not demonstrated by dopaminergic or serotonergic reward systems.

Authors+Show Affiliations

Department of Neuropsychiatry, Osaka City University Medical School, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2570687

Citation

Yamagami, S, and K Soejima. "Effect of Maprotiline Combined With Conventional Neuroleptics Against Negative Symptoms of Chronic Schizophrenia." Drugs Under Experimental and Clinical Research, vol. 15, no. 4, 1989, pp. 171-6.
Yamagami S, Soejima K. Effect of maprotiline combined with conventional neuroleptics against negative symptoms of chronic schizophrenia. Drugs Exp Clin Res. 1989;15(4):171-6.
Yamagami, S., & Soejima, K. (1989). Effect of maprotiline combined with conventional neuroleptics against negative symptoms of chronic schizophrenia. Drugs Under Experimental and Clinical Research, 15(4), 171-6.
Yamagami S, Soejima K. Effect of Maprotiline Combined With Conventional Neuroleptics Against Negative Symptoms of Chronic Schizophrenia. Drugs Exp Clin Res. 1989;15(4):171-6. PubMed PMID: 2570687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of maprotiline combined with conventional neuroleptics against negative symptoms of chronic schizophrenia. AU - Yamagami,S, AU - Soejima,K, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 171 EP - 6 JF - Drugs under experimental and clinical research JO - Drugs Exp Clin Res VL - 15 IS - 4 N2 - The therapeutic efficacy and target symptoms of maprotiline were tested by administering it in addition to conventional neuroleptic treatment for 10 weeks to a total of 32 chronic schizophrenic patients who showed no, or only partial, response to the neuroleptic medication. The final global improvement rating was 68.8% for all patients. Average therapeutic doses administered were 150 mg per day. Changes in psychotic symptoms were assessed by the Brief Psychiatric Rating Scale (BPRS), Psychiatric Evaluating scale (PES), and the Scale for the Assessment of Negative Symptoms (SANS). All mean improvement rates of these rating scales were observed at the 2nd week after the start of treatment, and maprotiline produced a marked amelioration in negative symptoms such as decreased spontaneity, blunted affect, emotional withdrawal, impaired work or recreation, etc. The incidence of side-effects was 37.5%. Constipation was the most frequently occurring side-effect. Neither side-effects nor laboratory test results were serious enough to discontinue the trial, except in the case of one chronic patient who showed acute exacerbation of symptoms due to maprotiline-induced insomnia, elation and hallucination. These results suggest that maprotiline improves the negative symptoms of schizophrenia by a noradrenaline potentiating action not demonstrated by dopaminergic or serotonergic reward systems. SN - 0378-6501 UR - https://www.unboundmedicine.com/medline/citation/2570687/Effect_of_maprotiline_combined_with_conventional_neuroleptics_against_negative_symptoms_of_chronic_schizophrenia_ L2 - http://www.diseaseinfosearch.org/result/6442 DB - PRIME DP - Unbound Medicine ER -