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Increased risk of erectile dysfunction among patients with sleep disorders: a nationwide population-based cohort study.
Int J Clin Pract. 2015 Aug; 69(8):846-52.IJ

Abstract

AIMS

Few studies have investigated the relationship between sleep disorders (SD) and erectile dysfunction (ED). Therefore, this study explored whether patients with SD in an Asian population are at an increased risk of developing ED.

METHODS

This longitudinal nationwide population-based cohort study investigated the incidence and risk of developing ED in 34,548 men newly diagnosed with SD between 2002 and 2008 from the National Health Insurance Research Database. A total of 138,192 controls without SD were randomly recruited from the general population and frequency matched according to age and sex. The follow-up period began from the date of entering the study cohort until the date of an ED event, censoring, or 31 December 2010. We conducted Cox proportional hazard regression analyses to estimate the effects of SD on the risk of ED.

RESULTS

The SD cohort had a 2.11-fold adjusted hazard ratio (HR) of subsequent ED development compared with the non-SD cohort [95% confidence interval (CI) = 1.89-2.37]. The incidence of ED increased with age for both cohorts and was higher for the patients in the SD cohort. Compared with the participants without SD or comorbidities, the patients without SD with any comorbidity exhibited a 1.79-fold risk of developing ED (95% CI = 1.54-2.09); the highest risk was for those with both SD and any comorbidity (HR = 3.34, 95% CI = 2.82-3.95). Furthermore, SD patients who had a particular number of comorbidities showed the dose-response effect of developing ED.

CONCLUSION

This nationwide cohort study determined that ED risk evidently increased in SD patients compared with the general population.

Authors+Show Affiliations

Department of Management Information Systems, Central Taiwan University of Science and Technology, Taichung, Taiwan.Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan. Department of Health Services Administration, China Medical University, Taichung, Taiwan.Department of Management Information Systems, Central Taiwan University of Science and Technology, Taichung, Taiwan.Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan.Department of Healthcare Administration, Central Taiwan University of Science and Technology, Taichung, Taiwan. Department of Health Services Administration, China Medical University, Taichung, Taiwan. Department of Internal Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25708176

Citation

Lin, H-H, et al. "Increased Risk of Erectile Dysfunction Among Patients With Sleep Disorders: a Nationwide Population-based Cohort Study." International Journal of Clinical Practice, vol. 69, no. 8, 2015, pp. 846-52.
Lin HH, Ho FM, Chen YF, et al. Increased risk of erectile dysfunction among patients with sleep disorders: a nationwide population-based cohort study. Int J Clin Pract. 2015;69(8):846-52.
Lin, H. H., Ho, F. M., Chen, Y. F., Tseng, C. M., Ho, C. C., & Chung, W. S. (2015). Increased risk of erectile dysfunction among patients with sleep disorders: a nationwide population-based cohort study. International Journal of Clinical Practice, 69(8), 846-52. https://doi.org/10.1111/ijcp.12629
Lin HH, et al. Increased Risk of Erectile Dysfunction Among Patients With Sleep Disorders: a Nationwide Population-based Cohort Study. Int J Clin Pract. 2015;69(8):846-52. PubMed PMID: 25708176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased risk of erectile dysfunction among patients with sleep disorders: a nationwide population-based cohort study. AU - Lin,H-H, AU - Ho,F-M, AU - Chen,Y-F, AU - Tseng,C-M, AU - Ho,C-C, AU - Chung,W-S, Y1 - 2015/02/24/ PY - 2015/2/25/entrez PY - 2015/2/25/pubmed PY - 2016/12/15/medline SP - 846 EP - 52 JF - International journal of clinical practice JO - Int J Clin Pract VL - 69 IS - 8 N2 - AIMS: Few studies have investigated the relationship between sleep disorders (SD) and erectile dysfunction (ED). Therefore, this study explored whether patients with SD in an Asian population are at an increased risk of developing ED. METHODS: This longitudinal nationwide population-based cohort study investigated the incidence and risk of developing ED in 34,548 men newly diagnosed with SD between 2002 and 2008 from the National Health Insurance Research Database. A total of 138,192 controls without SD were randomly recruited from the general population and frequency matched according to age and sex. The follow-up period began from the date of entering the study cohort until the date of an ED event, censoring, or 31 December 2010. We conducted Cox proportional hazard regression analyses to estimate the effects of SD on the risk of ED. RESULTS: The SD cohort had a 2.11-fold adjusted hazard ratio (HR) of subsequent ED development compared with the non-SD cohort [95% confidence interval (CI) = 1.89-2.37]. The incidence of ED increased with age for both cohorts and was higher for the patients in the SD cohort. Compared with the participants without SD or comorbidities, the patients without SD with any comorbidity exhibited a 1.79-fold risk of developing ED (95% CI = 1.54-2.09); the highest risk was for those with both SD and any comorbidity (HR = 3.34, 95% CI = 2.82-3.95). Furthermore, SD patients who had a particular number of comorbidities showed the dose-response effect of developing ED. CONCLUSION: This nationwide cohort study determined that ED risk evidently increased in SD patients compared with the general population. SN - 1742-1241 UR - https://www.unboundmedicine.com/medline/citation/25708176/Increased_risk_of_erectile_dysfunction_among_patients_with_sleep_disorders:_a_nationwide_population_based_cohort_study_ DB - PRIME DP - Unbound Medicine ER -