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Effects of acute transcranial direct current stimulation in hot and cold working memory tasks in healthy and depressed subjects.
Neurosci Lett 2015; 591:126-31NL

Abstract

Dorsolateral prefrontal cortex (DLPFC) hypoactivity and subcortical hyperactivity have been associated to cognitive impairment for non-emotional ("cold") and emotional ("hot") working memory tasks in major depressive disorder (MDD). We investigated whether an increase of DLPFC activity using transcranial direct current stimulation (tDCS) would differently influence the performance in working memory tasks in depressed and healthy subjects. Forty young adult participants (20 with MDD and 20 healthy controls) were randomized to a single, sham-controlled, bifrontal (left anodal/right cathodal), 2mA, 30min tDCS session in a parallel design. The n-back and the internal shift task (IST) were used as proxies of cold and hot working memory performance, respectively. Active tDCS compared to sham promoted more accurate and faster responses to the n-back task for both patients and controls. Conversely, only patients presented an improvement in response times for the IST task. Our findings suggest that the mechanisms of tDCS in MDD involve modulation of both cold and hot working memory. We discuss these findings considering the modulatory top-down effects of tDCS on subcortical structures via prefrontal activation, and how spreading of activation might be different for healthy volunteers versus depressed patients. We also discuss the role of tDCS in cognitive amelioration for depressed patients. Finally, the distinct effects of tDCS in the "hot" cognition task for healthy and depressed participants are indicative that tDCS outcomes are also regulated by differences in baseline activity of the stimulated network.

Authors+Show Affiliations

Interdisciplinary Center for Applied Neuromodulation (CINA), University Hospital, University of São Paulo, São Paulo, Brazil.Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.Interdisciplinary Center for Applied Neuromodulation (CINA), University Hospital, University of São Paulo, São Paulo, Brazil.Interdisciplinary Center for Applied Neuromodulation (CINA), University Hospital, University of São Paulo, São Paulo, Brazil.Interdisciplinary Center for Applied Neuromodulation (CINA), University Hospital, University of São Paulo, São Paulo, Brazil.Interdisciplinary Center for Applied Neuromodulation (CINA), University Hospital, University of São Paulo, São Paulo, Brazil; Service of Interdisciplinary Neuromodulation (SIN), Laboratory of Neurosciences (LIM-27), Department and Institute of Psychiatry, University of São Paulo, São Paulo, Brazil. Electronic address: brunoni@usp.br.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25708347

Citation

Moreno, Marina L., et al. "Effects of Acute Transcranial Direct Current Stimulation in Hot and Cold Working Memory Tasks in Healthy and Depressed Subjects." Neuroscience Letters, vol. 591, 2015, pp. 126-31.
Moreno ML, Vanderhasselt MA, Carvalho AF, et al. Effects of acute transcranial direct current stimulation in hot and cold working memory tasks in healthy and depressed subjects. Neurosci Lett. 2015;591:126-31.
Moreno, M. L., Vanderhasselt, M. A., Carvalho, A. F., Moffa, A. H., Lotufo, P. A., Benseñor, I. M., & Brunoni, A. R. (2015). Effects of acute transcranial direct current stimulation in hot and cold working memory tasks in healthy and depressed subjects. Neuroscience Letters, 591, pp. 126-31. doi:10.1016/j.neulet.2015.02.036.
Moreno ML, et al. Effects of Acute Transcranial Direct Current Stimulation in Hot and Cold Working Memory Tasks in Healthy and Depressed Subjects. Neurosci Lett. 2015 Mar 30;591:126-31. PubMed PMID: 25708347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute transcranial direct current stimulation in hot and cold working memory tasks in healthy and depressed subjects. AU - Moreno,Marina L, AU - Vanderhasselt,Marie-Anne, AU - Carvalho,Andre F, AU - Moffa,Adriano H, AU - Lotufo,Paulo A, AU - Benseñor,Isabela M, AU - Brunoni,Andre R, Y1 - 2015/02/20/ PY - 2014/12/19/received PY - 2015/02/05/revised PY - 2015/02/17/accepted PY - 2015/2/25/entrez PY - 2015/2/25/pubmed PY - 2015/9/16/medline KW - Cognition KW - Major depressive disorder KW - Transcranial direct current stimulation KW - Working memory SP - 126 EP - 31 JF - Neuroscience letters JO - Neurosci. Lett. VL - 591 N2 - Dorsolateral prefrontal cortex (DLPFC) hypoactivity and subcortical hyperactivity have been associated to cognitive impairment for non-emotional ("cold") and emotional ("hot") working memory tasks in major depressive disorder (MDD). We investigated whether an increase of DLPFC activity using transcranial direct current stimulation (tDCS) would differently influence the performance in working memory tasks in depressed and healthy subjects. Forty young adult participants (20 with MDD and 20 healthy controls) were randomized to a single, sham-controlled, bifrontal (left anodal/right cathodal), 2mA, 30min tDCS session in a parallel design. The n-back and the internal shift task (IST) were used as proxies of cold and hot working memory performance, respectively. Active tDCS compared to sham promoted more accurate and faster responses to the n-back task for both patients and controls. Conversely, only patients presented an improvement in response times for the IST task. Our findings suggest that the mechanisms of tDCS in MDD involve modulation of both cold and hot working memory. We discuss these findings considering the modulatory top-down effects of tDCS on subcortical structures via prefrontal activation, and how spreading of activation might be different for healthy volunteers versus depressed patients. We also discuss the role of tDCS in cognitive amelioration for depressed patients. Finally, the distinct effects of tDCS in the "hot" cognition task for healthy and depressed participants are indicative that tDCS outcomes are also regulated by differences in baseline activity of the stimulated network. SN - 1872-7972 UR - https://www.unboundmedicine.com/medline/citation/25708347/Effects_of_acute_transcranial_direct_current_stimulation_in_hot_and_cold_working_memory_tasks_in_healthy_and_depressed_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(15)00150-0 DB - PRIME DP - Unbound Medicine ER -