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Nano-composite of silk fibroin-chitosan/Nano ZrO2 for tissue engineering applications: fabrication and morphology.
Int J Biol Macromol. 2015 May; 76:292-302.IJ

Abstract

A scaffold possessing certain desired features such as biodegradation, biocompatibility, and porous structure could serve as a template for tissue engineering. In the present study, silk fibroin (SF), chitosan (CS) and zirconia (Nano ZrO2) were all combined using the freeze drying technique to fabricate a bio-composite scaffold. The composite scaffold (SF/CS/Nano ZrO2) was characterized by SEM, XRD, TGA, BET and FT-IR studies. The scaffold was found to possess a porous nature with pore dimensions suitable for cell infiltration and colonization. The presence of zirconia in the SF/CS/Nano ZrO2 scaffold led to an increase in compressive strength and water uptake capacity while at the same time decreasing the porosity. Cytocompatibility of the SF/CS/Nano ZrO2 scaffold, assessed by MTT assay, revealed non-toxicity to the Human Gingival Fibroblast (HGF, NCBI: C-131). Thus, we suggest that SF/CS/Nano ZrO2 composite scaffold is a potential candidate to be used for tissue engineering.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Teimouri A
Chemistry Department, Payame Noor University, Tehran 19395-3697, Iran. Electronic address: a_teimouri@pnu.ac.ir.
Ebrahimi R
Chemistry Department, Payame Noor University, Tehran 19395-3697, Iran.
Emadi R
Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran.
Beni BH
Department of Anatomical Sciences, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
Chermahini AN
Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran.

MeSH

Biocompatible MaterialsChitosanFibroinsHumansMaterials TestingNanocompositesPorositySilkSpectroscopy, Fourier Transform InfraredThermodynamicsTissue EngineeringTissue ScaffoldsX-Ray DiffractionZirconium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25709014

Citation

Teimouri, Abbas, et al. "Nano-composite of Silk fibroin-chitosan/Nano ZrO2 for Tissue Engineering Applications: Fabrication and Morphology." International Journal of Biological Macromolecules, vol. 76, 2015, pp. 292-302.
Teimouri A, Ebrahimi R, Emadi R, et al. Nano-composite of silk fibroin-chitosan/Nano ZrO2 for tissue engineering applications: fabrication and morphology. Int J Biol Macromol. 2015;76:292-302.
Teimouri, A., Ebrahimi, R., Emadi, R., Beni, B. H., & Chermahini, A. N. (2015). Nano-composite of silk fibroin-chitosan/Nano ZrO2 for tissue engineering applications: fabrication and morphology. International Journal of Biological Macromolecules, 76, 292-302. https://doi.org/10.1016/j.ijbiomac.2015.02.023
Teimouri A, et al. Nano-composite of Silk fibroin-chitosan/Nano ZrO2 for Tissue Engineering Applications: Fabrication and Morphology. Int J Biol Macromol. 2015;76:292-302. PubMed PMID: 25709014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nano-composite of silk fibroin-chitosan/Nano ZrO2 for tissue engineering applications: fabrication and morphology. AU - Teimouri,Abbas, AU - Ebrahimi,Raheleh, AU - Emadi,Rahmatollah, AU - Beni,Batool Hashemi, AU - Chermahini,Alireza Najafi, Y1 - 2015/02/20/ PY - 2014/12/31/received PY - 2015/02/10/revised PY - 2015/02/13/accepted PY - 2015/2/25/entrez PY - 2015/2/25/pubmed PY - 2015/12/31/medline KW - Chitosan KW - Microporous materials KW - Silk fibroin KW - Tissue engineering SP - 292 EP - 302 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 76 N2 - A scaffold possessing certain desired features such as biodegradation, biocompatibility, and porous structure could serve as a template for tissue engineering. In the present study, silk fibroin (SF), chitosan (CS) and zirconia (Nano ZrO2) were all combined using the freeze drying technique to fabricate a bio-composite scaffold. The composite scaffold (SF/CS/Nano ZrO2) was characterized by SEM, XRD, TGA, BET and FT-IR studies. The scaffold was found to possess a porous nature with pore dimensions suitable for cell infiltration and colonization. The presence of zirconia in the SF/CS/Nano ZrO2 scaffold led to an increase in compressive strength and water uptake capacity while at the same time decreasing the porosity. Cytocompatibility of the SF/CS/Nano ZrO2 scaffold, assessed by MTT assay, revealed non-toxicity to the Human Gingival Fibroblast (HGF, NCBI: C-131). Thus, we suggest that SF/CS/Nano ZrO2 composite scaffold is a potential candidate to be used for tissue engineering. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/25709014/Nano_composite_of_silk_fibroin_chitosan/Nano_ZrO2_for_tissue_engineering_applications:_fabrication_and_morphology_ DB - PRIME DP - Unbound Medicine ER -