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Use of coronary artery calcium scanning beyond coronary computed tomographic angiography in the emergency department evaluation for acute chest pain: the ROMICAT II trial.
Circ Cardiovasc Imaging. 2015 Mar; 8(3)CC

Abstract

BACKGROUND

Whether a coronary artery calcium (CAC) scan provides added value to coronary computed tomographic angiography (CCTA) in emergency department patients with acute chest pain remains unsettled. We sought to determine the value of CAC scan in patients with acute chest pain undergoing CCTA.

METHODS AND RESULTS

In the multicenter Rule Out Myocardial Infarction using Computer-Assisted Tomography (ROMICAT) II trial, we enrolled low-intermediate risk emergency department patients with symptoms suggesting acute coronary syndrome (ACS). In this prespecified subanalysis of 473 patients (54±8 years, 53% men) who underwent both CAC scanning and CCTA, the ACS rate was 8%. Overall, 53% of patients had CAC=0 of whom 2 (0.8%) developed ACS, whereas 7% had CAC>400 with 49% whom developed ACS. C-statistic of CAC>0 was 0.76, whereas that using the optimal cut point of CAC≥22 was 0.81. Continuous CAC score had lower discriminatory capacity than CCTA (c-statistic, 0.86 versus 0.92; P=0.03). Compared with CCTA alone, there was no benefit combining CAC score with CCTA (c-statistic, 0.93; P=0.88) or with selective CCTA strategies after initial CAC>0 or optimal cut point CAC≥22 (P≥0.09). Mean radiation dose from CAC acquisition was 1.4±0.7 mSv. Higher CAC scores resulted in more nondiagnostic CCTA studies although the majority remained interpretable.

CONCLUSIONS

In emergency department patients with acute chest pain, CAC score does not provide incremental value beyond CCTA for ACS diagnosis. CAC=0 does not exclude ACS, nor a high CAC score preclude interpretation of CCTA in most patients. Thus, CAC results should not influence the decision to proceed with CCTA, and the decision to perform a CAC scan should be balanced with the additional radiation exposure required.

CLINICAL TRIAL REGISTRATION URL

http://www.clinicaltrials.gov. Unique identifier: NCT01084239.

Authors+Show Affiliations

From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.).From the Cardiac MR PET CT Program, Division of Cardiology, Department of Radiology (A.P., W.S.M., U.H.), Emergency Department (J.T.N.), and Biostatistics Center (P.Z., H.L., D.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Cardiology Division, Kaiser Permanente Fontana Medical Center, CA (E.T.C.); Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, Weill Cornell Medical College, New York (R.C.D., Q.A.T.); Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO (P.K.W.); Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (J.L.F.); and Division of Cardiology and the Cardiovascular Center, Tufts Medical Center, Boston, MA (J.E.U.). qat9001@med.cornell.edu.

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25710925

Citation

Pursnani, Amit, et al. "Use of Coronary Artery Calcium Scanning Beyond Coronary Computed Tomographic Angiography in the Emergency Department Evaluation for Acute Chest Pain: the ROMICAT II Trial." Circulation. Cardiovascular Imaging, vol. 8, no. 3, 2015.
Pursnani A, Chou ET, Zakroysky P, et al. Use of coronary artery calcium scanning beyond coronary computed tomographic angiography in the emergency department evaluation for acute chest pain: the ROMICAT II trial. Circ Cardiovasc Imaging. 2015;8(3).
Pursnani, A., Chou, E. T., Zakroysky, P., Deaño, R. C., Mamuya, W. S., Woodard, P. K., Nagurney, J. T., Fleg, J. L., Lee, H., Schoenfeld, D., Udelson, J. E., Hoffmann, U., & Truong, Q. A. (2015). Use of coronary artery calcium scanning beyond coronary computed tomographic angiography in the emergency department evaluation for acute chest pain: the ROMICAT II trial. Circulation. Cardiovascular Imaging, 8(3). https://doi.org/10.1161/CIRCIMAGING.114.002225
Pursnani A, et al. Use of Coronary Artery Calcium Scanning Beyond Coronary Computed Tomographic Angiography in the Emergency Department Evaluation for Acute Chest Pain: the ROMICAT II Trial. Circ Cardiovasc Imaging. 2015;8(3) PubMed PMID: 25710925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of coronary artery calcium scanning beyond coronary computed tomographic angiography in the emergency department evaluation for acute chest pain: the ROMICAT II trial. AU - Pursnani,Amit, AU - Chou,Eric T, AU - Zakroysky,Pearl, AU - Deaño,Roderick C, AU - Mamuya,Wilfred S, AU - Woodard,Pamela K, AU - Nagurney,John T, AU - Fleg,Jerome L, AU - Lee,Hang, AU - Schoenfeld,David, AU - Udelson,James E, AU - Hoffmann,Udo, AU - Truong,Quynh A, Y1 - 2015/02/20/ PY - 2015/2/25/entrez PY - 2015/2/25/pubmed PY - 2015/4/10/medline KW - acute coronary syndrome KW - hospital emergency service KW - multidetector-row computed tomography JF - Circulation. Cardiovascular imaging JO - Circ Cardiovasc Imaging VL - 8 IS - 3 N2 - BACKGROUND: Whether a coronary artery calcium (CAC) scan provides added value to coronary computed tomographic angiography (CCTA) in emergency department patients with acute chest pain remains unsettled. We sought to determine the value of CAC scan in patients with acute chest pain undergoing CCTA. METHODS AND RESULTS: In the multicenter Rule Out Myocardial Infarction using Computer-Assisted Tomography (ROMICAT) II trial, we enrolled low-intermediate risk emergency department patients with symptoms suggesting acute coronary syndrome (ACS). In this prespecified subanalysis of 473 patients (54±8 years, 53% men) who underwent both CAC scanning and CCTA, the ACS rate was 8%. Overall, 53% of patients had CAC=0 of whom 2 (0.8%) developed ACS, whereas 7% had CAC>400 with 49% whom developed ACS. C-statistic of CAC>0 was 0.76, whereas that using the optimal cut point of CAC≥22 was 0.81. Continuous CAC score had lower discriminatory capacity than CCTA (c-statistic, 0.86 versus 0.92; P=0.03). Compared with CCTA alone, there was no benefit combining CAC score with CCTA (c-statistic, 0.93; P=0.88) or with selective CCTA strategies after initial CAC>0 or optimal cut point CAC≥22 (P≥0.09). Mean radiation dose from CAC acquisition was 1.4±0.7 mSv. Higher CAC scores resulted in more nondiagnostic CCTA studies although the majority remained interpretable. CONCLUSIONS: In emergency department patients with acute chest pain, CAC score does not provide incremental value beyond CCTA for ACS diagnosis. CAC=0 does not exclude ACS, nor a high CAC score preclude interpretation of CCTA in most patients. Thus, CAC results should not influence the decision to proceed with CCTA, and the decision to perform a CAC scan should be balanced with the additional radiation exposure required. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01084239. SN - 1942-0080 UR - https://www.unboundmedicine.com/medline/citation/25710925/Use_of_coronary_artery_calcium_scanning_beyond_coronary_computed_tomographic_angiography_in_the_emergency_department_evaluation_for_acute_chest_pain:_the_ROMICAT_II_trial_ L2 - https://www.ahajournals.org/doi/10.1161/CIRCIMAGING.114.002225?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -