Tags

Type your tag names separated by a space and hit enter

Effect of cysteamine on somatostatin-like immunoreactivity in the amygdala-kindled rat brain.
Neuropeptides. 1989 Jul; 14(1):11-6.N

Abstract

Previous studies have shown that a somatostatin-depleting drug, cysteamine (CYS), suppresses kindled seizures. However, no data is available concerning the levels of somatostatin-like immunoreactivity (SLI) in the kindled rat brain after CYS administration. In the present study, we used radioimmunoassay to measure SLI in the frontal cortex, amygdala + piriform cortex, hippocampus, striatum and hypothalamus: 1) in control rats, 2) in amygdala-kindled rats decapitated 14 days after the last stimulus, and 3) in amygdala-kindled rats decapitated 14 days after the last stimulus but treated either 11 days or 4) 4 hours before decapitation with CYS (100 mg/kg, subcutaneously). The results showed that, compared to controls, in kindled rats SLI was elevated both in the ipsi lateral (28%, p = 0.0372) and contralateral (17%, p = 0.0078) frontal cortex. Compared to kindled rats, CYS given 4 hours before decapitation decreased SLI in the frontal cortex (to 71%, p = 0.0066) and hippocampus (to 72%, p = 0.0027), but compared to the controls, only in the hippocampus. In rats given CYS 11 days before decapitation, SLI did not differ from either the controls or from the kindled rats. In conclusion, the somatostatinergic system is affected in amygdala-kindling; but the relationship of anatomical localization and the magnitude of CYS-induced decrease of SLI to elevated seizure threshold needs to be studied further.

Authors+Show Affiliations

Pitkänen A
Department of Neurology, University of Kuopio, Finland.
Hyttinen JM
No affiliation info available
Riekkinen PJ
No affiliation info available

MeSH

AmygdalaAnimalsBrainCorpus StriatumCysteamineFrontal LobeHippocampusHypothalamusKindling, NeurologicMalePeptidesRatsRats, Inbred StrainsSeizuresSomatostatinTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2571106

Citation

Pitkänen, A, et al. "Effect of Cysteamine On Somatostatin-like Immunoreactivity in the Amygdala-kindled Rat Brain." Neuropeptides, vol. 14, no. 1, 1989, pp. 11-6.
Pitkänen A, Hyttinen JM, Riekkinen PJ. Effect of cysteamine on somatostatin-like immunoreactivity in the amygdala-kindled rat brain. Neuropeptides. 1989;14(1):11-6.
Pitkänen, A., Hyttinen, J. M., & Riekkinen, P. J. (1989). Effect of cysteamine on somatostatin-like immunoreactivity in the amygdala-kindled rat brain. Neuropeptides, 14(1), 11-6.
Pitkänen A, Hyttinen JM, Riekkinen PJ. Effect of Cysteamine On Somatostatin-like Immunoreactivity in the Amygdala-kindled Rat Brain. Neuropeptides. 1989;14(1):11-6. PubMed PMID: 2571106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cysteamine on somatostatin-like immunoreactivity in the amygdala-kindled rat brain. AU - Pitkänen,A, AU - Hyttinen,J M, AU - Riekkinen,P J, PY - 1989/7/1/pubmed PY - 1989/7/1/medline PY - 1989/7/1/entrez SP - 11 EP - 6 JF - Neuropeptides JO - Neuropeptides VL - 14 IS - 1 N2 - Previous studies have shown that a somatostatin-depleting drug, cysteamine (CYS), suppresses kindled seizures. However, no data is available concerning the levels of somatostatin-like immunoreactivity (SLI) in the kindled rat brain after CYS administration. In the present study, we used radioimmunoassay to measure SLI in the frontal cortex, amygdala + piriform cortex, hippocampus, striatum and hypothalamus: 1) in control rats, 2) in amygdala-kindled rats decapitated 14 days after the last stimulus, and 3) in amygdala-kindled rats decapitated 14 days after the last stimulus but treated either 11 days or 4) 4 hours before decapitation with CYS (100 mg/kg, subcutaneously). The results showed that, compared to controls, in kindled rats SLI was elevated both in the ipsi lateral (28%, p = 0.0372) and contralateral (17%, p = 0.0078) frontal cortex. Compared to kindled rats, CYS given 4 hours before decapitation decreased SLI in the frontal cortex (to 71%, p = 0.0066) and hippocampus (to 72%, p = 0.0027), but compared to the controls, only in the hippocampus. In rats given CYS 11 days before decapitation, SLI did not differ from either the controls or from the kindled rats. In conclusion, the somatostatinergic system is affected in amygdala-kindling; but the relationship of anatomical localization and the magnitude of CYS-induced decrease of SLI to elevated seizure threshold needs to be studied further. SN - 0143-4179 UR - https://www.unboundmedicine.com/medline/citation/2571106/Effect_of_cysteamine_on_somatostatin_like_immunoreactivity_in_the_amygdala_kindled_rat_brain_ DB - PRIME DP - Unbound Medicine ER -