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The biological effect of the nitroimidazole derivative of a polypyridyl ruthenium complex on cancer and endothelial cells.
Metallomics. 2015 Mar; 7(3):553-66.M

Abstract

The ruthenium polypyridyl complexes [Ru(dip)2(bpy/bpy-2-nitroIm)](2+) (dip = 4,7-diphenyl-1,10-phenanthroline, bpy = 2,2'-bipyridine, bpy-2-nitroIm = 4-[3-(2-nitro-1H-imidazol-1-yl)propyl]) were found to be ca. ten times more cytotoxic against breast cancer (4T1) and human lung adenocarcinoma epithelial cells (A549) than a well-known anticancer drug, cisplatin. Even though the Ru complexes were quite cytotoxic towards FVB mouse lung microvascular endothelial cells (MLuMEC FVB) their efflux from these non transformed cells was much more efficient than from cancer ones. Both Ru complexes accumulated in cells. The cellular uptake of both Ru complexes occurs through passive diffusion while the nitroimidazole derivative is also endocytosed. They arrest cell growth in the S-phase and induce apoptosis. Such cell response can result from activation of oxidative stress by Ru complexes. The modulation of the mRNA expression profile for genes which might be involved in metastasis and angiogenesis processes by Ru complexes was analyzed for both cancer (4T1) and endothelial (MLuMEC FVB) cells. Ru complexes appeared to have a distinct impact on cell adhesion and migration as well as they affect endothelial cell vasculature. They are not only cytotoxic but are also potentially invasive and anti-metastatic agents. This work illustrates the putative future development of polypyridyl ruthenium.

Authors+Show Affiliations

Department of Inorganic Chemistry, Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland. brindell@chemia.uj.edu.pl.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25711770

Citation

Mazuryk, Olga, et al. "The Biological Effect of the Nitroimidazole Derivative of a Polypyridyl Ruthenium Complex On Cancer and Endothelial Cells." Metallomics : Integrated Biometal Science, vol. 7, no. 3, 2015, pp. 553-66.
Mazuryk O, Suzenet F, Kieda C, et al. The biological effect of the nitroimidazole derivative of a polypyridyl ruthenium complex on cancer and endothelial cells. Metallomics. 2015;7(3):553-66.
Mazuryk, O., Suzenet, F., Kieda, C., & Brindell, M. (2015). The biological effect of the nitroimidazole derivative of a polypyridyl ruthenium complex on cancer and endothelial cells. Metallomics : Integrated Biometal Science, 7(3), 553-66. https://doi.org/10.1039/c5mt00037h
Mazuryk O, et al. The Biological Effect of the Nitroimidazole Derivative of a Polypyridyl Ruthenium Complex On Cancer and Endothelial Cells. Metallomics. 2015;7(3):553-66. PubMed PMID: 25711770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The biological effect of the nitroimidazole derivative of a polypyridyl ruthenium complex on cancer and endothelial cells. AU - Mazuryk,Olga, AU - Suzenet,Franck, AU - Kieda,Claudine, AU - Brindell,Małgorzata, PY - 2015/2/26/entrez PY - 2015/2/26/pubmed PY - 2015/12/15/medline SP - 553 EP - 66 JF - Metallomics : integrated biometal science JO - Metallomics VL - 7 IS - 3 N2 - The ruthenium polypyridyl complexes [Ru(dip)2(bpy/bpy-2-nitroIm)](2+) (dip = 4,7-diphenyl-1,10-phenanthroline, bpy = 2,2'-bipyridine, bpy-2-nitroIm = 4-[3-(2-nitro-1H-imidazol-1-yl)propyl]) were found to be ca. ten times more cytotoxic against breast cancer (4T1) and human lung adenocarcinoma epithelial cells (A549) than a well-known anticancer drug, cisplatin. Even though the Ru complexes were quite cytotoxic towards FVB mouse lung microvascular endothelial cells (MLuMEC FVB) their efflux from these non transformed cells was much more efficient than from cancer ones. Both Ru complexes accumulated in cells. The cellular uptake of both Ru complexes occurs through passive diffusion while the nitroimidazole derivative is also endocytosed. They arrest cell growth in the S-phase and induce apoptosis. Such cell response can result from activation of oxidative stress by Ru complexes. The modulation of the mRNA expression profile for genes which might be involved in metastasis and angiogenesis processes by Ru complexes was analyzed for both cancer (4T1) and endothelial (MLuMEC FVB) cells. Ru complexes appeared to have a distinct impact on cell adhesion and migration as well as they affect endothelial cell vasculature. They are not only cytotoxic but are also potentially invasive and anti-metastatic agents. This work illustrates the putative future development of polypyridyl ruthenium. SN - 1756-591X UR - https://www.unboundmedicine.com/medline/citation/25711770/The_biological_effect_of_the_nitroimidazole_derivative_of_a_polypyridyl_ruthenium_complex_on_cancer_and_endothelial_cells_ L2 - https://doi.org/10.1039/c5mt00037h DB - PRIME DP - Unbound Medicine ER -