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Histamine receptors in unstimulated pancreatic exocrine secretion of the rabbit.
Agents Actions. 1989 Aug; 28(1-2):62-9.AA

Abstract

Histamine H2-receptor antagonists cimetidine and oxmetidine, H2-receptor agonist dimaprit, H1-receptor antagonist chlorpheniramine and H1-receptor agonist 2-thiazolylethylamine were tested for their effects on unstimulated pancreatic exocrine secretion in anaesthetized rabbits fitted with an acute pancreatic cannula. Intravenous administration of H1 agonist induces a dose-dependent increase in pancreatic secretion but H1 antagonist have the opposite effects. Intravenous administration of H2 antagonists induces effects similar the ones produced after H1 agonist infusion. The implications of H1 and H2 receptors on exocrine pancreatic secretion are discussed.

Authors+Show Affiliations

Department of Physiology, Faculty of Veterinary Sc, University of Extremadura, Cáceres, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2571245

Citation

Pariente, J A., et al. "Histamine Receptors in Unstimulated Pancreatic Exocrine Secretion of the Rabbit." Agents and Actions, vol. 28, no. 1-2, 1989, pp. 62-9.
Pariente JA, Madrid JA, Salido GM. Histamine receptors in unstimulated pancreatic exocrine secretion of the rabbit. Agents Actions. 1989;28(1-2):62-9.
Pariente, J. A., Madrid, J. A., & Salido, G. M. (1989). Histamine receptors in unstimulated pancreatic exocrine secretion of the rabbit. Agents and Actions, 28(1-2), 62-9.
Pariente JA, Madrid JA, Salido GM. Histamine Receptors in Unstimulated Pancreatic Exocrine Secretion of the Rabbit. Agents Actions. 1989;28(1-2):62-9. PubMed PMID: 2571245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histamine receptors in unstimulated pancreatic exocrine secretion of the rabbit. AU - Pariente,J A, AU - Madrid,J A, AU - Salido,G M, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez SP - 62 EP - 9 JF - Agents and actions JO - Agents Actions VL - 28 IS - 1-2 N2 - Histamine H2-receptor antagonists cimetidine and oxmetidine, H2-receptor agonist dimaprit, H1-receptor antagonist chlorpheniramine and H1-receptor agonist 2-thiazolylethylamine were tested for their effects on unstimulated pancreatic exocrine secretion in anaesthetized rabbits fitted with an acute pancreatic cannula. Intravenous administration of H1 agonist induces a dose-dependent increase in pancreatic secretion but H1 antagonist have the opposite effects. Intravenous administration of H2 antagonists induces effects similar the ones produced after H1 agonist infusion. The implications of H1 and H2 receptors on exocrine pancreatic secretion are discussed. SN - 0065-4299 UR - https://www.unboundmedicine.com/medline/citation/2571245/Histamine_receptors_in_unstimulated_pancreatic_exocrine_secretion_of_the_rabbit_ DB - PRIME DP - Unbound Medicine ER -