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Changes in pneumococcal nasopharyngeal colonization among children with respiratory tract infections before and after use of the two new extended-valency pneumococcal conjugated vaccines.
Infect Dis (Lond). 2015 Jun; 47(6):385-92.ID

Abstract

BACKGROUND

The 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7-valent PCV (PCV7) in May 2010 in Korea. We investigated the dynamics of pneumococcal nasopharyngeal (NP) colonization in children with a respiratory illness before and after use of PHiD-CV and PCV13.

METHODS

From March 2009 to December 2012 NP secretions were obtained from 2176 children aged < 5 years with respiratory diseases. We used the multiplex polymerase chain reaction (PCR) technique to determine pneumococcal serotypes.

RESULTS

Among the samples, 468 (21.5%) specimens were positive by multiplex PCR. The overall pneumococcal colonization rate remained stable during the 2009-2012 periods. The serotypes present in PCV7 and serotype 19A decreased in frequency from 36.8% and 26.4% in 2009 to 10.1% and 11.4% in 2012, respectively (χ(2) for trend, P < 0.001 and P = 0.007, respectively). The frequency of non-PCV13 serotypes increased from 36.8% in 2009 to 78.5% in 2012 (χ(2) for trend, P < 0.001). There was no significant difference in carriage rates of each serotype between groups of children that received PCV7, PHiD-CV, or PCV13.

CONCLUSIONS

Compared with the period of PCV7 vaccination, overall carriage rate was not affected by the introduction of new PCVs. However, serotype distribution now consists mostly of non-vaccine serotypes. PCVs affect mucosal immunity against Streptococcus pneumoniae (SP) in NP carriage; but, global SP colonization seems to be maintained by replacement.

Authors+Show Affiliations

From the 1 Department of Pediatrics, School of Medicine, Ewha Womans University , Seoul , Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25712791

Citation

Ahn, Jong Gyun, et al. "Changes in Pneumococcal Nasopharyngeal Colonization Among Children With Respiratory Tract Infections Before and After Use of the Two New Extended-valency Pneumococcal Conjugated Vaccines." Infectious Diseases (London, England), vol. 47, no. 6, 2015, pp. 385-92.
Ahn JG, Choi SY, Kim DS, et al. Changes in pneumococcal nasopharyngeal colonization among children with respiratory tract infections before and after use of the two new extended-valency pneumococcal conjugated vaccines. Infect Dis (Lond). 2015;47(6):385-92.
Ahn, J. G., Choi, S. Y., Kim, D. S., & Kim, K. H. (2015). Changes in pneumococcal nasopharyngeal colonization among children with respiratory tract infections before and after use of the two new extended-valency pneumococcal conjugated vaccines. Infectious Diseases (London, England), 47(6), 385-92. https://doi.org/10.3109/00365548.2014.1001997
Ahn JG, et al. Changes in Pneumococcal Nasopharyngeal Colonization Among Children With Respiratory Tract Infections Before and After Use of the Two New Extended-valency Pneumococcal Conjugated Vaccines. Infect Dis (Lond). 2015;47(6):385-92. PubMed PMID: 25712791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in pneumococcal nasopharyngeal colonization among children with respiratory tract infections before and after use of the two new extended-valency pneumococcal conjugated vaccines. AU - Ahn,Jong Gyun, AU - Choi,Seong Yeol, AU - Kim,Dong Soo, AU - Kim,Ki Hwan, Y1 - 2015/02/24/ PY - 2015/2/26/entrez PY - 2015/2/26/pubmed PY - 2016/1/28/medline KW - Streptococcus pneumoniae KW - nasopharyngeal colonization KW - pneumococcal conjugate vaccine KW - serotype SP - 385 EP - 92 JF - Infectious diseases (London, England) JO - Infect Dis (Lond) VL - 47 IS - 6 N2 - BACKGROUND: The 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV13) replaced the 7-valent PCV (PCV7) in May 2010 in Korea. We investigated the dynamics of pneumococcal nasopharyngeal (NP) colonization in children with a respiratory illness before and after use of PHiD-CV and PCV13. METHODS: From March 2009 to December 2012 NP secretions were obtained from 2176 children aged < 5 years with respiratory diseases. We used the multiplex polymerase chain reaction (PCR) technique to determine pneumococcal serotypes. RESULTS: Among the samples, 468 (21.5%) specimens were positive by multiplex PCR. The overall pneumococcal colonization rate remained stable during the 2009-2012 periods. The serotypes present in PCV7 and serotype 19A decreased in frequency from 36.8% and 26.4% in 2009 to 10.1% and 11.4% in 2012, respectively (χ(2) for trend, P < 0.001 and P = 0.007, respectively). The frequency of non-PCV13 serotypes increased from 36.8% in 2009 to 78.5% in 2012 (χ(2) for trend, P < 0.001). There was no significant difference in carriage rates of each serotype between groups of children that received PCV7, PHiD-CV, or PCV13. CONCLUSIONS: Compared with the period of PCV7 vaccination, overall carriage rate was not affected by the introduction of new PCVs. However, serotype distribution now consists mostly of non-vaccine serotypes. PCVs affect mucosal immunity against Streptococcus pneumoniae (SP) in NP carriage; but, global SP colonization seems to be maintained by replacement. SN - 2374-4243 UR - https://www.unboundmedicine.com/medline/citation/25712791/Changes_in_pneumococcal_nasopharyngeal_colonization_among_children_with_respiratory_tract_infections_before_and_after_use_of_the_two_new_extended_valency_pneumococcal_conjugated_vaccines_ L2 - https://www.tandfonline.com/doi/abs/10.3109/00365548.2014.1001997 DB - PRIME DP - Unbound Medicine ER -