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Characterization and solubility study of norfloxacin-polyethylene glycol, polyvinylpyrrolidone and carbopol 974p solid dispersions.
Recent Pat Drug Deliv Formul. 2015; 9(2):167-82.RP

Abstract

OBJECTIVE

Norfloxacin has a low aqueous solubility which leads to poor dissolution. Keeping this fact in mind the purpose of the present study is to formulate and evaluate norfloxacin solid dispersion.

METHODS

Solid dispersions were prepared using hydrophilic carriers like polyethylene glycol (PEG) 4000, polyvinylpyrrolidone (PVP) k30 and carbopol 974pNF (CP) in various ratios using solvent evaporation technique. These formulations were evaluated using solubility studies, dissolution studies; Fourier transmitted infrared spectroscopy (FTIR), X-ray diffraction (XRD), and differential scanning calorimetery (DSC). The influence of polymer type and drug to polymer ratio on the solubility and dissolution rate of norfloxacin was also evaluated.

RESULTS

FTIR analysis showed no interaction of all three polymers with norfloxacin. The results from XRD and DSC analyses of the solid dispersion preparations showed that norfloxacin existsin its amorphous form. Among the Norfloxacin: PEG solid dispersions, Norfloxacin: PEG 1:14 ratio showed the highest dissolution rate at pH 6.8. For norfloxacin: PVP solid dispersions, norfloxacin: PVP 1:10 ratio showed the highest dissolution rate at pH 6.8. For Norfloxacin: CP solid dispersions, norfloxacin: P 1:2 ratio showed the highest dissolution rate at pH 6.8.

CONCLUSION

The solid dispersion of norfloxacin with polyethylene glycol (PEG) 4000, polyvinylpyrrolidone (PVP) k30 and carbopol 974p NF (CP), lends an ample credence for better therapeutic efficacy.

Authors+Show Affiliations

Dept. of Pharmaceutical Technology, School of Pharmacy, International Medical University, Bukit Jalil, 57000 KL, Malaysia. adinarayana_gorajana@imu.edu.my.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25714525

Citation

Gorajana, Adinarayana, et al. "Characterization and Solubility Study of Norfloxacin-polyethylene Glycol, Polyvinylpyrrolidone and Carbopol 974p Solid Dispersions." Recent Patents On Drug Delivery & Formulation, vol. 9, no. 2, 2015, pp. 167-82.
Gorajana A, Kit WW, Dua K. Characterization and solubility study of norfloxacin-polyethylene glycol, polyvinylpyrrolidone and carbopol 974p solid dispersions. Recent Pat Drug Deliv Formul. 2015;9(2):167-82.
Gorajana, A., Kit, W. W., & Dua, K. (2015). Characterization and solubility study of norfloxacin-polyethylene glycol, polyvinylpyrrolidone and carbopol 974p solid dispersions. Recent Patents On Drug Delivery & Formulation, 9(2), 167-82.
Gorajana A, Kit WW, Dua K. Characterization and Solubility Study of Norfloxacin-polyethylene Glycol, Polyvinylpyrrolidone and Carbopol 974p Solid Dispersions. Recent Pat Drug Deliv Formul. 2015;9(2):167-82. PubMed PMID: 25714525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization and solubility study of norfloxacin-polyethylene glycol, polyvinylpyrrolidone and carbopol 974p solid dispersions. AU - Gorajana,Adinarayana, AU - Kit,Wong W, AU - Dua,Kamal, PY - 2014/12/10/received PY - 2015/02/19/revised PY - 2015/02/20/accepted PY - 2015/2/26/entrez PY - 2015/2/26/pubmed PY - 2016/3/15/medline SP - 167 EP - 82 JF - Recent patents on drug delivery & formulation JO - Recent Pat Drug Deliv Formul VL - 9 IS - 2 N2 - OBJECTIVE: Norfloxacin has a low aqueous solubility which leads to poor dissolution. Keeping this fact in mind the purpose of the present study is to formulate and evaluate norfloxacin solid dispersion. METHODS: Solid dispersions were prepared using hydrophilic carriers like polyethylene glycol (PEG) 4000, polyvinylpyrrolidone (PVP) k30 and carbopol 974pNF (CP) in various ratios using solvent evaporation technique. These formulations were evaluated using solubility studies, dissolution studies; Fourier transmitted infrared spectroscopy (FTIR), X-ray diffraction (XRD), and differential scanning calorimetery (DSC). The influence of polymer type and drug to polymer ratio on the solubility and dissolution rate of norfloxacin was also evaluated. RESULTS: FTIR analysis showed no interaction of all three polymers with norfloxacin. The results from XRD and DSC analyses of the solid dispersion preparations showed that norfloxacin existsin its amorphous form. Among the Norfloxacin: PEG solid dispersions, Norfloxacin: PEG 1:14 ratio showed the highest dissolution rate at pH 6.8. For norfloxacin: PVP solid dispersions, norfloxacin: PVP 1:10 ratio showed the highest dissolution rate at pH 6.8. For Norfloxacin: CP solid dispersions, norfloxacin: P 1:2 ratio showed the highest dissolution rate at pH 6.8. CONCLUSION: The solid dispersion of norfloxacin with polyethylene glycol (PEG) 4000, polyvinylpyrrolidone (PVP) k30 and carbopol 974p NF (CP), lends an ample credence for better therapeutic efficacy. SN - 2212-4039 UR - https://www.unboundmedicine.com/medline/citation/25714525/Characterization_and_solubility_study_of_norfloxacin_polyethylene_glycol_polyvinylpyrrolidone_and_carbopol_974p_solid_dispersions_ L2 - http://www.eurekaselect.com/128798/article DB - PRIME DP - Unbound Medicine ER -