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Combination therapy with intravitreal bevacizumab and macular grid and scatter laser photocoagulation in patients with macular edema secondary to branch retinal vein occlusion.
J Ocul Pharmacol Ther. 2015 Apr; 31(3):179-85.JO

Abstract

PURPOSE

To assess the efficacy of combined intravitreal bevacizumab (IVB) and macular grid and scatter laser photocoagulation in the treatment of macular edema secondary to branch retinal vein occlusion (BRVO) over a 12-month period.

METHODS

A prospective, interventional case series study was conducted in 20 patients. Patients were treated with 3 monthly IVB injections, followed by macular grid laser and scatter laser photocoagulation to nonperfused ischemic retina. Repeated IVB injections were performed on an as-needed basis when patients had recurrent macular edema.

RESULTS

The best-corrected visual acuity of 20/40 or better was achieved in 17 eyes (85%) and a vision gain of 3 lines or more was noted in 12/20 eyes (60%). Mean visual acuity improved from 0.68 logMAR at baseline to 0.28 logMAR at 3 months, 0.26 logMAR at 6 months, and 0.26 logMAR at 12 months (P<0.01). The mean central macular thickness (CMT) was 442 μm at baseline and decreased to 266, 264, 300, and 294 μm at 1, 3, 6, and 12 months' follow-up, respectively (P<0.01). A mild rebound CMT increase was noted at 6 months, which was reduced after bevacizumab reinjection. Ten patients (50%) required repeated IVB injections. Fifteen eyes (75%) have complete edema resolution on optical coherence tomography scan at the 12-month return visit. Overall, patients received an average of 4 injections during the 12-month period. No adverse ocular or systemic events were observed following injections.

CONCLUSIONS

Early IVB injections in combination with subsequent macular grid and scatter laser photocoagulation treatment significantly improved vision and reduced macular edema secondary to BRVO. Further studies are warranted to evaluate the long-term outcomes and safety.

Authors+Show Affiliations

1 Department of Ophthalmology, Taipei Veterans General Hospital , Taipei, Taiwan, Republic of China .No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25715024

Citation

Yang, Chang-Sue, et al. "Combination Therapy With Intravitreal Bevacizumab and Macular Grid and Scatter Laser Photocoagulation in Patients With Macular Edema Secondary to Branch Retinal Vein Occlusion." Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics, vol. 31, no. 3, 2015, pp. 179-85.
Yang CS, Liu JH, Chung YC, et al. Combination therapy with intravitreal bevacizumab and macular grid and scatter laser photocoagulation in patients with macular edema secondary to branch retinal vein occlusion. J Ocul Pharmacol Ther. 2015;31(3):179-85.
Yang, C. S., Liu, J. H., Chung, Y. C., Chou, Y. B., & Hung, K. H. (2015). Combination therapy with intravitreal bevacizumab and macular grid and scatter laser photocoagulation in patients with macular edema secondary to branch retinal vein occlusion. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics, 31(3), 179-85. https://doi.org/10.1089/jop.2014.0069
Yang CS, et al. Combination Therapy With Intravitreal Bevacizumab and Macular Grid and Scatter Laser Photocoagulation in Patients With Macular Edema Secondary to Branch Retinal Vein Occlusion. J Ocul Pharmacol Ther. 2015;31(3):179-85. PubMed PMID: 25715024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combination therapy with intravitreal bevacizumab and macular grid and scatter laser photocoagulation in patients with macular edema secondary to branch retinal vein occlusion. AU - Yang,Chang-Sue, AU - Liu,Jorn-Hon, AU - Chung,Yu-Chien, AU - Chou,Yu-Bai, AU - Hung,Kuo-Hsuan, Y1 - 2015/02/25/ PY - 2015/2/26/entrez PY - 2015/2/26/pubmed PY - 2016/1/2/medline SP - 179 EP - 85 JF - Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics JO - J Ocul Pharmacol Ther VL - 31 IS - 3 N2 - PURPOSE: To assess the efficacy of combined intravitreal bevacizumab (IVB) and macular grid and scatter laser photocoagulation in the treatment of macular edema secondary to branch retinal vein occlusion (BRVO) over a 12-month period. METHODS: A prospective, interventional case series study was conducted in 20 patients. Patients were treated with 3 monthly IVB injections, followed by macular grid laser and scatter laser photocoagulation to nonperfused ischemic retina. Repeated IVB injections were performed on an as-needed basis when patients had recurrent macular edema. RESULTS: The best-corrected visual acuity of 20/40 or better was achieved in 17 eyes (85%) and a vision gain of 3 lines or more was noted in 12/20 eyes (60%). Mean visual acuity improved from 0.68 logMAR at baseline to 0.28 logMAR at 3 months, 0.26 logMAR at 6 months, and 0.26 logMAR at 12 months (P<0.01). The mean central macular thickness (CMT) was 442 μm at baseline and decreased to 266, 264, 300, and 294 μm at 1, 3, 6, and 12 months' follow-up, respectively (P<0.01). A mild rebound CMT increase was noted at 6 months, which was reduced after bevacizumab reinjection. Ten patients (50%) required repeated IVB injections. Fifteen eyes (75%) have complete edema resolution on optical coherence tomography scan at the 12-month return visit. Overall, patients received an average of 4 injections during the 12-month period. No adverse ocular or systemic events were observed following injections. CONCLUSIONS: Early IVB injections in combination with subsequent macular grid and scatter laser photocoagulation treatment significantly improved vision and reduced macular edema secondary to BRVO. Further studies are warranted to evaluate the long-term outcomes and safety. SN - 1557-7732 UR - https://www.unboundmedicine.com/medline/citation/25715024/Combination_therapy_with_intravitreal_bevacizumab_and_macular_grid_and_scatter_laser_photocoagulation_in_patients_with_macular_edema_secondary_to_branch_retinal_vein_occlusion_ L2 - https://www.liebertpub.com/doi/10.1089/jop.2014.0069?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -