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Dietary intake of carotenoids and risk of type 2 diabetes.

Abstract

BACKGROUND AND AIMS

Carotenoids may reduce diabetes risk, due to their antioxidant properties. However, the association between dietary carotenoids intake and type 2 diabetes risk is still unclear. Therefore, the objective of this study was to examine whether higher dietary carotenoid intakes associate with reduced type 2 diabetes risk.

METHODS AND RESULTS

Data from 37,846 participants of the European Prospective Investigation into Cancer and Nutrition- Netherlands study were analyzed. Dietary intakes of β-carotene, α-carotene, β-cryptoxanthin, lycopene, lutein & zeaxanthin and the sum of these carotenoids were assessed using a validated food frequency questionnaire. Incident type 2 diabetes was mainly self-reported, and verified against general practitioner information. Mean ±SD total carotenoid intake was 10 ± 4 mg/day. During a mean ±SD follow-up of 10 ± 2 years, 915 incident cases of type 2 diabetes were ascertained. After adjustment for age, sex, diabetes risk factors, dietary intake, waist circumference and BMI, higher β-carotene intakes associated inversely with diabetes risk [Hazard Ratio quartile 4 versus quartile 1 (HR(Q4)): 0.78 (95%CI:0.64,0.95), P-linear trend 0.01]. For α-carotene, a borderline significant reduced risk was observed, with a HR(Q4) of 0.85 (95%CI:0.70,1.03), and P-linear trend 0.05. β-cryptoxanthin, lycopene, lutein & zeaxanthin, and the sum of all carotenoids did not associate with diabetes risk.

CONCLUSIONS

This study shows that diets high in β-carotene and α-carotene are associated with reduced type 2 diabetes in generally healthy men and women.

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    Authors+Show Affiliations

    Sluijs I
    ,

    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: i.sluijs-2@umcutrecht.nl.

    Cadier E
    ,

    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

    Beulens JW
    ,

    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

    van der A DL
    ,

    Center for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

    Spijkerman AM
    ,

    Center for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.

    van der Schouw YT

    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.

    Source

    MeSH

    Aged
    Antioxidants
    Carotenoids
    Cryptoxanthins
    Diabetes Mellitus, Type 2
    Energy Metabolism
    Female
    Follow-Up Studies
    Humans
    Incidence
    Lutein
    Lycopene
    Male
    Middle Aged
    Netherlands
    Nutrition Assessment
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires
    Zeaxanthins
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25716098

    Citation

    Sluijs, I, et al. "Dietary Intake of Carotenoids and Risk of Type 2 Diabetes." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 25, no. 4, 2015, pp. 376-81.
    Sluijs I, Cadier E, Beulens JW, et al. Dietary intake of carotenoids and risk of type 2 diabetes. Nutr Metab Cardiovasc Dis. 2015;25(4):376-81.
    Sluijs, I., Cadier, E., Beulens, J. W., van der A, D. L., Spijkerman, A. M., & van der Schouw, Y. T. (2015). Dietary intake of carotenoids and risk of type 2 diabetes. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 25(4), pp. 376-81. doi:10.1016/j.numecd.2014.12.008.
    Sluijs I, et al. Dietary Intake of Carotenoids and Risk of Type 2 Diabetes. Nutr Metab Cardiovasc Dis. 2015;25(4):376-81. PubMed PMID: 25716098.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of carotenoids and risk of type 2 diabetes. AU - Sluijs,I, AU - Cadier,E, AU - Beulens,J W J, AU - van der A,D L, AU - Spijkerman,A M W, AU - van der Schouw,Y T, Y1 - 2014/12/31/ PY - 2014/06/04/received PY - 2014/11/28/revised PY - 2014/12/22/accepted PY - 2015/2/27/entrez PY - 2015/2/27/pubmed PY - 2016/1/12/medline KW - Carotenoids KW - Cohort study KW - Diet KW - Type 2 diabetes KW - α-carotene KW - β-carotene SP - 376 EP - 81 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 25 IS - 4 N2 - BACKGROUND AND AIMS: Carotenoids may reduce diabetes risk, due to their antioxidant properties. However, the association between dietary carotenoids intake and type 2 diabetes risk is still unclear. Therefore, the objective of this study was to examine whether higher dietary carotenoid intakes associate with reduced type 2 diabetes risk. METHODS AND RESULTS: Data from 37,846 participants of the European Prospective Investigation into Cancer and Nutrition- Netherlands study were analyzed. Dietary intakes of β-carotene, α-carotene, β-cryptoxanthin, lycopene, lutein & zeaxanthin and the sum of these carotenoids were assessed using a validated food frequency questionnaire. Incident type 2 diabetes was mainly self-reported, and verified against general practitioner information. Mean ±SD total carotenoid intake was 10 ± 4 mg/day. During a mean ±SD follow-up of 10 ± 2 years, 915 incident cases of type 2 diabetes were ascertained. After adjustment for age, sex, diabetes risk factors, dietary intake, waist circumference and BMI, higher β-carotene intakes associated inversely with diabetes risk [Hazard Ratio quartile 4 versus quartile 1 (HR(Q4)): 0.78 (95%CI:0.64,0.95), P-linear trend 0.01]. For α-carotene, a borderline significant reduced risk was observed, with a HR(Q4) of 0.85 (95%CI:0.70,1.03), and P-linear trend 0.05. β-cryptoxanthin, lycopene, lutein & zeaxanthin, and the sum of all carotenoids did not associate with diabetes risk. CONCLUSIONS: This study shows that diets high in β-carotene and α-carotene are associated with reduced type 2 diabetes in generally healthy men and women. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/25716098/Dietary_intake_of_carotenoids_and_risk_of_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(14)00373-1 DB - PRIME DP - Unbound Medicine ER -