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Neurodegenerative diseases and therapeutic strategies using iron chelators.
J Trace Elem Med Biol. 2015; 31:267-73.JT

Abstract

This review will summarise the current state of our knowledge concerning the involvement of iron in various neurological diseases and the potential of therapy with iron chelators to retard the progression of the disease. We first discuss briefly the role of metal ions in brain function before outlining the way by which transition metal ions, such as iron and copper, can initiate neurodegeneration through the generation of reactive oxygen and nitrogen species. This results in protein misfolding, amyloid production and formation of insoluble protein aggregates which are contained within inclusion bodies. This will activate microglia leading to neuroinflammation. Neuroinflammation plays an important role in the progression of the neurodegenerative diseases, with activated microglia releasing pro-inflammatory cytokines leading to cellular cell loss. The evidence for metal involvement in Parkinson's and Alzheimer's disease as well as Friedreich's ataxia and multiple sclerosis will be presented. Preliminary results from trials of iron chelation therapy in these neurodegenerative diseases will be reviewed.

Authors+Show Affiliations

Centre for Neuroinflammation & Neurodegeneration, Imperial College London, Hammersmith Hospital Campus, London W120NN, UK; Universite Catholique de Louvain, Louvain-la-Neuve, Belgium. Electronic address: roberta.ward@uclouvain.be.Centre for Neuroinflammation & Neurodegeneration, Imperial College London, Hammersmith Hospital Campus, London W120NN, UK.Universite Catholique de Louvain, Louvain-la-Neuve, Belgium.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25716300

Citation

Ward, Roberta J., et al. "Neurodegenerative Diseases and Therapeutic Strategies Using Iron Chelators." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 31, 2015, pp. 267-73.
Ward RJ, Dexter DT, Crichton RR. Neurodegenerative diseases and therapeutic strategies using iron chelators. J Trace Elem Med Biol. 2015;31:267-73.
Ward, R. J., Dexter, D. T., & Crichton, R. R. (2015). Neurodegenerative diseases and therapeutic strategies using iron chelators. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 31, 267-73. https://doi.org/10.1016/j.jtemb.2014.12.012
Ward RJ, Dexter DT, Crichton RR. Neurodegenerative Diseases and Therapeutic Strategies Using Iron Chelators. J Trace Elem Med Biol. 2015;31:267-73. PubMed PMID: 25716300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurodegenerative diseases and therapeutic strategies using iron chelators. AU - Ward,Roberta J, AU - Dexter,David T, AU - Crichton,Robert R, Y1 - 2015/01/22/ PY - 2014/09/19/received PY - 2014/11/27/revised PY - 2014/12/27/accepted PY - 2015/2/27/entrez PY - 2015/2/27/pubmed PY - 2016/2/20/medline KW - Chelation KW - Iron KW - Neurodegenerative diseases SP - 267 EP - 73 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 31 N2 - This review will summarise the current state of our knowledge concerning the involvement of iron in various neurological diseases and the potential of therapy with iron chelators to retard the progression of the disease. We first discuss briefly the role of metal ions in brain function before outlining the way by which transition metal ions, such as iron and copper, can initiate neurodegeneration through the generation of reactive oxygen and nitrogen species. This results in protein misfolding, amyloid production and formation of insoluble protein aggregates which are contained within inclusion bodies. This will activate microglia leading to neuroinflammation. Neuroinflammation plays an important role in the progression of the neurodegenerative diseases, with activated microglia releasing pro-inflammatory cytokines leading to cellular cell loss. The evidence for metal involvement in Parkinson's and Alzheimer's disease as well as Friedreich's ataxia and multiple sclerosis will be presented. Preliminary results from trials of iron chelation therapy in these neurodegenerative diseases will be reviewed. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/25716300/Neurodegenerative_diseases_and_therapeutic_strategies_using_iron_chelators_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(15)00006-1 DB - PRIME DP - Unbound Medicine ER -