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Repeated administration of antidepressants enhances agonist affinity for mesolimbic D2-receptors.
J Pharm Pharmacol. 1989 Aug; 41(8):555-8.JP

Abstract

Studies have shown an increased responsiveness of the dopaminergic system after repeated administration of a variety of antidepressant drugs. In the present study, the effect of repeated administration (twice daily for 14 days) of imipramine and mianserin on the affinity of dopamine D2-receptors for quinpirole, a D2-agonist, and on the quinpirole-induced locomotor hyperactivity was examined in rats. Repeated doses of imipramine and mianserin increased the affinity of quinpirole for [3H]spiperone binding sites in membranes prepared from the limbic system but not the striatum. The locomotor hyperactivity induced by quinpirole was enhanced by chronic treatment with both antidepressants. The data indicate that the enhanced responsiveness of the dopaminergic system in rats, observed after chronic treatment with antidepressants, may result from an increased affinity of agonists at D2-receptors in the mesolimbic system.

Authors+Show Affiliations

Institute of Pharmacology, Polish Academy of Science, Krakow.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2571700

Citation

Klimek, V, and J Maj. "Repeated Administration of Antidepressants Enhances Agonist Affinity for Mesolimbic D2-receptors." The Journal of Pharmacy and Pharmacology, vol. 41, no. 8, 1989, pp. 555-8.
Klimek V, Maj J. Repeated administration of antidepressants enhances agonist affinity for mesolimbic D2-receptors. J Pharm Pharmacol. 1989;41(8):555-8.
Klimek, V., & Maj, J. (1989). Repeated administration of antidepressants enhances agonist affinity for mesolimbic D2-receptors. The Journal of Pharmacy and Pharmacology, 41(8), 555-8.
Klimek V, Maj J. Repeated Administration of Antidepressants Enhances Agonist Affinity for Mesolimbic D2-receptors. J Pharm Pharmacol. 1989;41(8):555-8. PubMed PMID: 2571700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repeated administration of antidepressants enhances agonist affinity for mesolimbic D2-receptors. AU - Klimek,V, AU - Maj,J, PY - 1989/8/1/pubmed PY - 1989/8/1/medline PY - 1989/8/1/entrez SP - 555 EP - 8 JF - The Journal of pharmacy and pharmacology JO - J. Pharm. Pharmacol. VL - 41 IS - 8 N2 - Studies have shown an increased responsiveness of the dopaminergic system after repeated administration of a variety of antidepressant drugs. In the present study, the effect of repeated administration (twice daily for 14 days) of imipramine and mianserin on the affinity of dopamine D2-receptors for quinpirole, a D2-agonist, and on the quinpirole-induced locomotor hyperactivity was examined in rats. Repeated doses of imipramine and mianserin increased the affinity of quinpirole for [3H]spiperone binding sites in membranes prepared from the limbic system but not the striatum. The locomotor hyperactivity induced by quinpirole was enhanced by chronic treatment with both antidepressants. The data indicate that the enhanced responsiveness of the dopaminergic system in rats, observed after chronic treatment with antidepressants, may result from an increased affinity of agonists at D2-receptors in the mesolimbic system. SN - 0022-3573 UR - https://www.unboundmedicine.com/medline/citation/2571700/Repeated_administration_of_antidepressants_enhances_agonist_affinity_for_mesolimbic_D2_receptors_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0022-3573&date=1989&volume=41&issue=8&spage=555 DB - PRIME DP - Unbound Medicine ER -