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Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects.
J Glaucoma. 2015 Oct-Nov; 24(8):583-90.JG

Abstract

PURPOSE

To elucidate patterns of macular ganglion cell-inner plexiform layer (GCIPL) defects by Cirrus optical coherence tomography (OCT) and examine the spatial relationship between GCIPL defect and visual field (VF) defect patterns.

METHODS

A total of 116 eyes of 116 normal subjects and 111 eyes of 111 glaucoma patients were included. The 227 study subjects underwent Cirrus OCT imaging in macular cube mode and reliable standard VF testing. Two ophthalmologists blindly classified GCIPL defect patterns and VF defects. The frequency distribution of GCIPL defect patterns and spatial relationships between GCIPL defects and VF defects were investigated.

RESULTS

GCIPL defect patterns were classified as minimal, inner, outer, diffuse mild, diffuse severe, inferior confined, inferior dominant, superior confined, and superior dominant defects in normal controls (71.6%, 7.8%, 4.3%, 1.7%, 0%, 10.3%, 1.7%, 1.7%, and 0.9%, respectively) and in glaucoma patients (11.7%, 3.6%, 4.5%, 7.2%, 21.6%, 22.5%, 18.0%, 4.5%, and 6.3%, respectively). In mild and moderate glaucoma patients, the inferior confined type was most frequent (21.9% and 50.0%, respectively). However, the diffuse severe type was most frequent (59.1%) in advanced glaucoma patients. The locations of the VF defects corresponded to the locations of the GCIPL defects in glaucoma patients (P=0.012).

CONCLUSIONS

Glaucomatous damage of the macula was common and more frequent in the inferior retina. GCIPL defect patterns as determined by SD-OCT imaging corresponded well with central VF defects. It seems macular GCIPL analysis may be useful for evaluating glaucomatous optic neuropathy.

Authors+Show Affiliations

*Department of Ophthalmology and Inha Vision Science Laboratory, Inha University School of Medicine, Incheon †Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25719232

Citation

Jeong, Jae Seung, et al. "Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated By Spectral-Domain OCT in Glaucoma Patients and Normal Subjects." Journal of Glaucoma, vol. 24, no. 8, 2015, pp. 583-90.
Jeong JS, Kang MG, Kim CY, et al. Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects. J Glaucoma. 2015;24(8):583-90.
Jeong, J. S., Kang, M. G., Kim, C. Y., & Kim, N. R. (2015). Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects. Journal of Glaucoma, 24(8), 583-90. https://doi.org/10.1097/IJG.0000000000000231
Jeong JS, et al. Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated By Spectral-Domain OCT in Glaucoma Patients and Normal Subjects. J Glaucoma. 2015 Oct-Nov;24(8):583-90. PubMed PMID: 25719232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pattern of Macular Ganglion Cell-Inner Plexiform Layer Defect Generated by Spectral-Domain OCT in Glaucoma Patients and Normal Subjects. AU - Jeong,Jae Seung, AU - Kang,Min Gu, AU - Kim,Chan Yun, AU - Kim,Na Rae, PY - 2015/2/27/entrez PY - 2015/2/27/pubmed PY - 2016/1/15/medline SP - 583 EP - 90 JF - Journal of glaucoma JO - J. Glaucoma VL - 24 IS - 8 N2 - PURPOSE: To elucidate patterns of macular ganglion cell-inner plexiform layer (GCIPL) defects by Cirrus optical coherence tomography (OCT) and examine the spatial relationship between GCIPL defect and visual field (VF) defect patterns. METHODS: A total of 116 eyes of 116 normal subjects and 111 eyes of 111 glaucoma patients were included. The 227 study subjects underwent Cirrus OCT imaging in macular cube mode and reliable standard VF testing. Two ophthalmologists blindly classified GCIPL defect patterns and VF defects. The frequency distribution of GCIPL defect patterns and spatial relationships between GCIPL defects and VF defects were investigated. RESULTS: GCIPL defect patterns were classified as minimal, inner, outer, diffuse mild, diffuse severe, inferior confined, inferior dominant, superior confined, and superior dominant defects in normal controls (71.6%, 7.8%, 4.3%, 1.7%, 0%, 10.3%, 1.7%, 1.7%, and 0.9%, respectively) and in glaucoma patients (11.7%, 3.6%, 4.5%, 7.2%, 21.6%, 22.5%, 18.0%, 4.5%, and 6.3%, respectively). In mild and moderate glaucoma patients, the inferior confined type was most frequent (21.9% and 50.0%, respectively). However, the diffuse severe type was most frequent (59.1%) in advanced glaucoma patients. The locations of the VF defects corresponded to the locations of the GCIPL defects in glaucoma patients (P=0.012). CONCLUSIONS: Glaucomatous damage of the macula was common and more frequent in the inferior retina. GCIPL defect patterns as determined by SD-OCT imaging corresponded well with central VF defects. It seems macular GCIPL analysis may be useful for evaluating glaucomatous optic neuropathy. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/25719232/Pattern_of_Macular_Ganglion_Cell_Inner_Plexiform_Layer_Defect_Generated_by_Spectral_Domain_OCT_in_Glaucoma_Patients_and_Normal_Subjects_ L2 - http://dx.doi.org/10.1097/IJG.0000000000000231 DB - PRIME DP - Unbound Medicine ER -