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Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial.
Br J Nutr 2015; 113(6):984-95BJ

Abstract

The dietary inflammatory index (DII) is a new tool to assess the inflammatory potential of the diet. In the present study, we aimed to determine the association between the DII and BMI, waist circumference and waist:height ratio (WHtR). We conducted a cross-sectional study of 7236 participants recruited into the PREvención con DIeta MEDiterránea trial. Information from a validated 137-item FFQ was used to calculate energy, food and nutrient intakes. A fourteen-item dietary screener was used to assess adherence to the Mediterranean diet (MeDiet). Sex-specific multivariable linear regression models were fitted to estimate differences (and 95 % CI) in BMI, waist circumference and WHtR across the quintiles of the DII. All nutrient intakes, healthy foods and adherence to the MeDiet were higher in the quintile with the lowest DII score (more anti-inflammatory values) except for intakes of animal protein, saturated fat and monounsaturated fat. Although an inverse association between the DII and total energy was apparent, the DII was associated with higher average BMI, waist circumference and WHtR after adjusting for known risk factors. The adjusted difference in the WHtR for women and men between the highest and lowest quintiles of the DII was 1·60 % (95 % CI 0·87, 2·33) and 1·04 % (95 % CI 0·35, 1·74), respectively. Pro-inflammatory scores remained associated with obesity after controlling for the effect that adherence to a MeDiet had on inflammation. In conclusion, the present study shows a direct association between the DII and indices of obesity, and supports the hypothesis that diet may have a role in the development of obesity through inflammatory modulation mechanisms.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health,Facultad de Medicina-Clínica Universidad de Navarra, School of Medicine, Universidad de Navarra,Irunlarrea 1,31080Pamplona, Navarra,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.Cancer Prevention and Control Program, University of South Carolina,Columbia,SC,USA.Cancer Prevention and Control Program, University of South Carolina,Columbia,SC,USA.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.Department of Preventive Medicine and Public Health,Facultad de Medicina-Clínica Universidad de Navarra, School of Medicine, Universidad de Navarra,Irunlarrea 1,31080Pamplona, Navarra,Spain.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25720588

Citation

Ruiz-Canela, M, et al. "Dietary Inflammatory Index and Anthropometric Measures of Obesity in a Population Sample at High Cardiovascular Risk From the PREDIMED (PREvención Con DIeta MEDiterránea) Trial." The British Journal of Nutrition, vol. 113, no. 6, 2015, pp. 984-95.
Ruiz-Canela M, Zazpe I, Shivappa N, et al. Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial. Br J Nutr. 2015;113(6):984-95.
Ruiz-Canela, M., Zazpe, I., Shivappa, N., Hébert, J. R., Sánchez-Tainta, A., Corella, D., ... Martínez-González, M. A. (2015). Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial. The British Journal of Nutrition, 113(6), pp. 984-95. doi:10.1017/S0007114514004401.
Ruiz-Canela M, et al. Dietary Inflammatory Index and Anthropometric Measures of Obesity in a Population Sample at High Cardiovascular Risk From the PREDIMED (PREvención Con DIeta MEDiterránea) Trial. Br J Nutr. 2015 Mar 28;113(6):984-95. PubMed PMID: 25720588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial. AU - Ruiz-Canela,M, AU - Zazpe,I, AU - Shivappa,N, AU - Hébert,J R, AU - Sánchez-Tainta,A, AU - Corella,D, AU - Salas-Salvadó,J, AU - Fitó,M, AU - Lamuela-Raventós,R M, AU - Rekondo,J, AU - Fernández-Crehuet,J, AU - Fiol,M, AU - Santos-Lozano,J M, AU - Serra-Majem,L, AU - Pinto,X, AU - Martínez,J A, AU - Ros,E, AU - Estruch,R, AU - Martínez-González,M A, Y1 - 2015/02/27/ PY - 2015/2/28/entrez PY - 2015/2/28/pubmed PY - 2015/6/20/medline KW - Waist:height ratio SP - 984 EP - 95 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 113 IS - 6 N2 - The dietary inflammatory index (DII) is a new tool to assess the inflammatory potential of the diet. In the present study, we aimed to determine the association between the DII and BMI, waist circumference and waist:height ratio (WHtR). We conducted a cross-sectional study of 7236 participants recruited into the PREvención con DIeta MEDiterránea trial. Information from a validated 137-item FFQ was used to calculate energy, food and nutrient intakes. A fourteen-item dietary screener was used to assess adherence to the Mediterranean diet (MeDiet). Sex-specific multivariable linear regression models were fitted to estimate differences (and 95 % CI) in BMI, waist circumference and WHtR across the quintiles of the DII. All nutrient intakes, healthy foods and adherence to the MeDiet were higher in the quintile with the lowest DII score (more anti-inflammatory values) except for intakes of animal protein, saturated fat and monounsaturated fat. Although an inverse association between the DII and total energy was apparent, the DII was associated with higher average BMI, waist circumference and WHtR after adjusting for known risk factors. The adjusted difference in the WHtR for women and men between the highest and lowest quintiles of the DII was 1·60 % (95 % CI 0·87, 2·33) and 1·04 % (95 % CI 0·35, 1·74), respectively. Pro-inflammatory scores remained associated with obesity after controlling for the effect that adherence to a MeDiet had on inflammation. In conclusion, the present study shows a direct association between the DII and indices of obesity, and supports the hypothesis that diet may have a role in the development of obesity through inflammatory modulation mechanisms. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25720588/Dietary_inflammatory_index_and_anthropometric_measures_of_obesity_in_a_population_sample_at_high_cardiovascular_risk_from_the_PREDIMED__PREvención_con_DIeta_MEDiterránea__trial_ L2 - https://www.cambridge.org/core/product/identifier/S0007114514004401/type/journal_article DB - PRIME DP - Unbound Medicine ER -