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Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial.

Abstract

The dietary inflammatory index (DII) is a new tool to assess the inflammatory potential of the diet. In the present study, we aimed to determine the association between the DII and BMI, waist circumference and waist:height ratio (WHtR). We conducted a cross-sectional study of 7236 participants recruited into the PREvención con DIeta MEDiterránea trial. Information from a validated 137-item FFQ was used to calculate energy, food and nutrient intakes. A fourteen-item dietary screener was used to assess adherence to the Mediterranean diet (MeDiet). Sex-specific multivariable linear regression models were fitted to estimate differences (and 95 % CI) in BMI, waist circumference and WHtR across the quintiles of the DII. All nutrient intakes, healthy foods and adherence to the MeDiet were higher in the quintile with the lowest DII score (more anti-inflammatory values) except for intakes of animal protein, saturated fat and monounsaturated fat. Although an inverse association between the DII and total energy was apparent, the DII was associated with higher average BMI, waist circumference and WHtR after adjusting for known risk factors. The adjusted difference in the WHtR for women and men between the highest and lowest quintiles of the DII was 1·60 % (95 % CI 0·87, 2·33) and 1·04 % (95 % CI 0·35, 1·74), respectively. Pro-inflammatory scores remained associated with obesity after controlling for the effect that adherence to a MeDiet had on inflammation. In conclusion, the present study shows a direct association between the DII and indices of obesity, and supports the hypothesis that diet may have a role in the development of obesity through inflammatory modulation mechanisms.

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    Department of Preventive Medicine and Public Health,Facultad de Medicina-Clínica Universidad de Navarra, School of Medicine, Universidad de Navarra,Irunlarrea 1,31080Pamplona, Navarra,Spain.

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    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

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    Cancer Prevention and Control Program, University of South Carolina,Columbia,SC,USA.

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    Cancer Prevention and Control Program, University of South Carolina,Columbia,SC,USA.

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    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

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    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    ,

    CIBER Fisiopatología de la Obesidad y Nutrición (CIBER obn), Instituto de Salud Carlos III,Madrid,Spain.

    Department of Preventive Medicine and Public Health,Facultad de Medicina-Clínica Universidad de Navarra, School of Medicine, Universidad de Navarra,Irunlarrea 1,31080Pamplona, Navarra,Spain.

    Source

    The British journal of nutrition 113:6 2015 Mar 28 pg 984-95

    MeSH

    Aged
    Aged, 80 and over
    Body Mass Index
    Cardiovascular Diseases
    Cross-Sectional Studies
    Diet, Mediterranean
    Energy Intake
    Female
    Health Promotion
    Humans
    Male
    Middle Aged
    Nutrition Policy
    Obesity
    Patient Compliance
    Risk Factors
    Spain
    Surveys and Questionnaires
    Waist Circumference
    Waist-Height Ratio

    Pub Type(s)

    Comparative Study
    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25720588

    Citation

    Ruiz-Canela, M, et al. "Dietary Inflammatory Index and Anthropometric Measures of Obesity in a Population Sample at High Cardiovascular Risk From the PREDIMED (PREvención Con DIeta MEDiterránea) Trial." The British Journal of Nutrition, vol. 113, no. 6, 2015, pp. 984-95.
    Ruiz-Canela M, Zazpe I, Shivappa N, et al. Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial. Br J Nutr. 2015;113(6):984-95.
    Ruiz-Canela, M., Zazpe, I., Shivappa, N., Hébert, J. R., Sánchez-Tainta, A., Corella, D., ... Martínez-González, M. A. (2015). Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial. The British Journal of Nutrition, 113(6), pp. 984-95. doi:10.1017/S0007114514004401.
    Ruiz-Canela M, et al. Dietary Inflammatory Index and Anthropometric Measures of Obesity in a Population Sample at High Cardiovascular Risk From the PREDIMED (PREvención Con DIeta MEDiterránea) Trial. Br J Nutr. 2015 Mar 28;113(6):984-95. PubMed PMID: 25720588.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED (PREvención con DIeta MEDiterránea) trial. AU - Ruiz-Canela,M, AU - Zazpe,I, AU - Shivappa,N, AU - Hébert,J R, AU - Sánchez-Tainta,A, AU - Corella,D, AU - Salas-Salvadó,J, AU - Fitó,M, AU - Lamuela-Raventós,R M, AU - Rekondo,J, AU - Fernández-Crehuet,J, AU - Fiol,M, AU - Santos-Lozano,J M, AU - Serra-Majem,L, AU - Pinto,X, AU - Martínez,J A, AU - Ros,E, AU - Estruch,R, AU - Martínez-González,M A, Y1 - 2015/02/27/ PY - 2015/2/28/entrez PY - 2015/2/28/pubmed PY - 2015/6/20/medline KW - Waist:height ratio SP - 984 EP - 95 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 113 IS - 6 N2 - The dietary inflammatory index (DII) is a new tool to assess the inflammatory potential of the diet. In the present study, we aimed to determine the association between the DII and BMI, waist circumference and waist:height ratio (WHtR). We conducted a cross-sectional study of 7236 participants recruited into the PREvención con DIeta MEDiterránea trial. Information from a validated 137-item FFQ was used to calculate energy, food and nutrient intakes. A fourteen-item dietary screener was used to assess adherence to the Mediterranean diet (MeDiet). Sex-specific multivariable linear regression models were fitted to estimate differences (and 95 % CI) in BMI, waist circumference and WHtR across the quintiles of the DII. All nutrient intakes, healthy foods and adherence to the MeDiet were higher in the quintile with the lowest DII score (more anti-inflammatory values) except for intakes of animal protein, saturated fat and monounsaturated fat. Although an inverse association between the DII and total energy was apparent, the DII was associated with higher average BMI, waist circumference and WHtR after adjusting for known risk factors. The adjusted difference in the WHtR for women and men between the highest and lowest quintiles of the DII was 1·60 % (95 % CI 0·87, 2·33) and 1·04 % (95 % CI 0·35, 1·74), respectively. Pro-inflammatory scores remained associated with obesity after controlling for the effect that adherence to a MeDiet had on inflammation. In conclusion, the present study shows a direct association between the DII and indices of obesity, and supports the hypothesis that diet may have a role in the development of obesity through inflammatory modulation mechanisms. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25720588/Dietary_inflammatory_index_and_anthropometric_measures_of_obesity_in_a_population_sample_at_high_cardiovascular_risk_from_the_PREDIMED__PREvención_con_DIeta_MEDiterránea__trial_ L2 - https://www.cambridge.org/core/product/identifier/S0007114514004401/type/journal_article DB - PRIME DP - Unbound Medicine ER -