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Association between vitamin C intake and glioma risk: evidence from a meta-analysis.
Neuroepidemiology 2015; 44(1):39-44N

Abstract

BACKGROUND

The field of quantifying the association between the intake of vitamin C and risk of glioma still has conflicts. Thus, we performed a comprehensive meta-analysis to test the hypothesis that a high intake of vitamin C may be a protective effect on glioma risk.

METHODS

Pertinent studies were identified by a search in PubMed and Web of Knowledge up to June 2014. The random-effect model was used to combine study-specific results. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test.

RESULTS

Thirteen articles with 15 studies (2 cohort study and 13 case-control studies) involving 3,409 glioma cases about vitamin C intake and glioma risk were used in this meta-analysis. The combined relative risks (RRs) of glioma associated with vitamin C intake was 0.86 (95% CIs = 0.75-0.99). Overall, significant protective associations were also found in the American population (RRs = 0.85, 95% CIs = 0.73-0.98) and case-control studies (RRs = 0.80, 95% CIs = 0.69-0.93). No publication bias was found.

CONCLUSIONS

Our analysis indicated that vitamin C intake might decrease the risk of glioma, especially among the Americans.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25720916

Citation

Zhou, Siru, et al. "Association Between Vitamin C Intake and Glioma Risk: Evidence From a Meta-analysis." Neuroepidemiology, vol. 44, no. 1, 2015, pp. 39-44.
Zhou S, Wang X, Tan Y, et al. Association between vitamin C intake and glioma risk: evidence from a meta-analysis. Neuroepidemiology. 2015;44(1):39-44.
Zhou, S., Wang, X., Tan, Y., Qiu, L., Fang, H., & Li, W. (2015). Association between vitamin C intake and glioma risk: evidence from a meta-analysis. Neuroepidemiology, 44(1), pp. 39-44.
Zhou S, et al. Association Between Vitamin C Intake and Glioma Risk: Evidence From a Meta-analysis. Neuroepidemiology. 2015;44(1):39-44. PubMed PMID: 25720916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between vitamin C intake and glioma risk: evidence from a meta-analysis. AU - Zhou,Siru, AU - Wang,Xiaoya, AU - Tan,Ya, AU - Qiu,Lingli, AU - Fang,Huan, AU - Li,Wei, Y1 - 2015/02/17/ PY - 2014/08/31/received PY - 2014/10/31/accepted PY - 2015/2/28/entrez PY - 2015/2/28/pubmed PY - 2016/1/7/medline SP - 39 EP - 44 JF - Neuroepidemiology JO - Neuroepidemiology VL - 44 IS - 1 N2 - BACKGROUND: The field of quantifying the association between the intake of vitamin C and risk of glioma still has conflicts. Thus, we performed a comprehensive meta-analysis to test the hypothesis that a high intake of vitamin C may be a protective effect on glioma risk. METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to June 2014. The random-effect model was used to combine study-specific results. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test. RESULTS: Thirteen articles with 15 studies (2 cohort study and 13 case-control studies) involving 3,409 glioma cases about vitamin C intake and glioma risk were used in this meta-analysis. The combined relative risks (RRs) of glioma associated with vitamin C intake was 0.86 (95% CIs = 0.75-0.99). Overall, significant protective associations were also found in the American population (RRs = 0.85, 95% CIs = 0.73-0.98) and case-control studies (RRs = 0.80, 95% CIs = 0.69-0.93). No publication bias was found. CONCLUSIONS: Our analysis indicated that vitamin C intake might decrease the risk of glioma, especially among the Americans. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/25720916/Association_between_vitamin_C_intake_and_glioma_risk:_evidence_from_a_meta_analysis_ L2 - https://www.karger.com?DOI=10.1159/000369814 DB - PRIME DP - Unbound Medicine ER -