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Association between vitamin C intake and glioma risk: evidence from a meta-analysis.

Abstract

BACKGROUND

The field of quantifying the association between the intake of vitamin C and risk of glioma still has conflicts. Thus, we performed a comprehensive meta-analysis to test the hypothesis that a high intake of vitamin C may be a protective effect on glioma risk.

METHODS

Pertinent studies were identified by a search in PubMed and Web of Knowledge up to June 2014. The random-effect model was used to combine study-specific results. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test.

RESULTS

Thirteen articles with 15 studies (2 cohort study and 13 case-control studies) involving 3,409 glioma cases about vitamin C intake and glioma risk were used in this meta-analysis. The combined relative risks (RRs) of glioma associated with vitamin C intake was 0.86 (95% CIs = 0.75-0.99). Overall, significant protective associations were also found in the American population (RRs = 0.85, 95% CIs = 0.73-0.98) and case-control studies (RRs = 0.80, 95% CIs = 0.69-0.93). No publication bias was found.

CONCLUSIONS

Our analysis indicated that vitamin C intake might decrease the risk of glioma, especially among the Americans.

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  • Authors

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    Source

    Neuroepidemiology 44:1 2015 pg 39-44

    MeSH

    Ascorbic Acid
    Brain Neoplasms
    Diet
    Glioma
    Humans
    Risk

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    25720916

    Citation

    Zhou, Siru, et al. "Association Between Vitamin C Intake and Glioma Risk: Evidence From a Meta-analysis." Neuroepidemiology, vol. 44, no. 1, 2015, pp. 39-44.
    Zhou S, Wang X, Tan Y, et al. Association between vitamin C intake and glioma risk: evidence from a meta-analysis. Neuroepidemiology. 2015;44(1):39-44.
    Zhou, S., Wang, X., Tan, Y., Qiu, L., Fang, H., & Li, W. (2015). Association between vitamin C intake and glioma risk: evidence from a meta-analysis. Neuroepidemiology, 44(1), pp. 39-44.
    Zhou S, et al. Association Between Vitamin C Intake and Glioma Risk: Evidence From a Meta-analysis. Neuroepidemiology. 2015;44(1):39-44. PubMed PMID: 25720916.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between vitamin C intake and glioma risk: evidence from a meta-analysis. AU - Zhou,Siru, AU - Wang,Xiaoya, AU - Tan,Ya, AU - Qiu,Lingli, AU - Fang,Huan, AU - Li,Wei, Y1 - 2015/02/17/ PY - 2014/08/31/received PY - 2014/10/31/accepted PY - 2015/2/28/entrez PY - 2015/2/28/pubmed PY - 2016/1/7/medline SP - 39 EP - 44 JF - Neuroepidemiology JO - Neuroepidemiology VL - 44 IS - 1 N2 - BACKGROUND: The field of quantifying the association between the intake of vitamin C and risk of glioma still has conflicts. Thus, we performed a comprehensive meta-analysis to test the hypothesis that a high intake of vitamin C may be a protective effect on glioma risk. METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to June 2014. The random-effect model was used to combine study-specific results. Publication bias was estimated using Begg' funnel plot and Egger's regression asymmetry test. RESULTS: Thirteen articles with 15 studies (2 cohort study and 13 case-control studies) involving 3,409 glioma cases about vitamin C intake and glioma risk were used in this meta-analysis. The combined relative risks (RRs) of glioma associated with vitamin C intake was 0.86 (95% CIs = 0.75-0.99). Overall, significant protective associations were also found in the American population (RRs = 0.85, 95% CIs = 0.73-0.98) and case-control studies (RRs = 0.80, 95% CIs = 0.69-0.93). No publication bias was found. CONCLUSIONS: Our analysis indicated that vitamin C intake might decrease the risk of glioma, especially among the Americans. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/25720916/Association_between_vitamin_C_intake_and_glioma_risk:_evidence_from_a_meta_analysis_ L2 - https://www.karger.com?DOI=10.1159/000369814 DB - PRIME DP - Unbound Medicine ER -