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A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages.
Food Funct. 2015 Apr; 6(4):1212-7.FF

Abstract

In this study, we examined the ex vivo urinary anti-adhesion activity of low-calorie cranberry extract beverages in both a pilot study (n = 10) and a randomized, double-blind, placebo controlled clinical trial (n = 59). In the pilot study, subjects consumed a cranberry extract beverage (CEB) or a cranberry extract and juice beverage (CEJB), compared to placebo. Both cranberry beverages utilized a standardized cranberry extract powder at a level equivalent to low-calorie cranberry juice cocktail (LCJC) on a PAC content basis. Clean-catch urine samples collected at baseline and post intervention were tested for anti-adhesion activity utilizing a mannose-resistant human red blood cell hemagglutination assay specific for P-fimbriated E. coli. Results from the pilot study indicated that ex vivo anti-adhesion activity for both cranberry treatments were higher (p < 0.05) than placebo. In the clinical trial, we compared CEJB to LCJC and a placebo beverage. Post-consumption urine from both cranberry treatment groups showed significantly higher (p < 0.05) anti-adhesion activity compared to placebo. There were no differences observed in anti-adhesion activity between CJEB and LCJC, indicating similar bioactivity. Therefore, acute beverage consumption of cranberry extract and/or juice provides ex vivo anti-adhesion activity, which may help to improve urinary tract health.

Authors+Show Affiliations

Ocean Spray Cranberries, Inc., One Ocean Spray Drive, Lakeville-Middleboro, MA 02349, USA. ckhoo@oceanspray.com.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25723356

Citation

Kaspar, Kerrie L., et al. "A Randomized, Double-blind, Placebo-controlled Trial to Assess the Bacterial Anti-adhesion Effects of Cranberry Extract Beverages." Food & Function, vol. 6, no. 4, 2015, pp. 1212-7.
Kaspar KL, Howell AB, Khoo C. A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages. Food Funct. 2015;6(4):1212-7.
Kaspar, K. L., Howell, A. B., & Khoo, C. (2015). A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages. Food & Function, 6(4), 1212-7. https://doi.org/10.1039/c4fo01018c
Kaspar KL, Howell AB, Khoo C. A Randomized, Double-blind, Placebo-controlled Trial to Assess the Bacterial Anti-adhesion Effects of Cranberry Extract Beverages. Food Funct. 2015;6(4):1212-7. PubMed PMID: 25723356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages. AU - Kaspar,Kerrie L, AU - Howell,Amy B, AU - Khoo,Christina, PY - 2015/2/28/entrez PY - 2015/2/28/pubmed PY - 2016/3/2/medline SP - 1212 EP - 7 JF - Food & function JO - Food Funct VL - 6 IS - 4 N2 - In this study, we examined the ex vivo urinary anti-adhesion activity of low-calorie cranberry extract beverages in both a pilot study (n = 10) and a randomized, double-blind, placebo controlled clinical trial (n = 59). In the pilot study, subjects consumed a cranberry extract beverage (CEB) or a cranberry extract and juice beverage (CEJB), compared to placebo. Both cranberry beverages utilized a standardized cranberry extract powder at a level equivalent to low-calorie cranberry juice cocktail (LCJC) on a PAC content basis. Clean-catch urine samples collected at baseline and post intervention were tested for anti-adhesion activity utilizing a mannose-resistant human red blood cell hemagglutination assay specific for P-fimbriated E. coli. Results from the pilot study indicated that ex vivo anti-adhesion activity for both cranberry treatments were higher (p < 0.05) than placebo. In the clinical trial, we compared CEJB to LCJC and a placebo beverage. Post-consumption urine from both cranberry treatment groups showed significantly higher (p < 0.05) anti-adhesion activity compared to placebo. There were no differences observed in anti-adhesion activity between CJEB and LCJC, indicating similar bioactivity. Therefore, acute beverage consumption of cranberry extract and/or juice provides ex vivo anti-adhesion activity, which may help to improve urinary tract health. SN - 2042-650X UR - https://www.unboundmedicine.com/medline/citation/25723356/A_randomized_double_blind_placebo_controlled_trial_to_assess_the_bacterial_anti_adhesion_effects_of_cranberry_extract_beverages_ L2 - https://doi.org/10.1039/c4fo01018c DB - PRIME DP - Unbound Medicine ER -