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Ru(II)-catalyzed oxidative spiroannulation of 2-arylphenols with alkynes via a C-H activation/dearomatization strategy.
J Org Chem. 2015 Mar 20; 80(6):3349-56.JO

Abstract

An intermolecular spiroannulation reaction of appropriately substituted 2-arylphenols with internal alkynes has been developed by using a Ru(II) catalyst and an oxidant. This transformation was realized by a phenol-directed C-H activation, migratory insertion of the alkyne, and subsequent dearomatization of the phenolic ring, providing a broad range of highly functionalized spirocyclic compounds in moderate yields with high regioselectivity.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25723782

Citation

Zuo, Zhijun, et al. "Ru(II)-catalyzed Oxidative Spiroannulation of 2-arylphenols With Alkynes Via a C-H Activation/dearomatization Strategy." The Journal of Organic Chemistry, vol. 80, no. 6, 2015, pp. 3349-56.
Zuo Z, Yang X, Liu J, et al. Ru(II)-catalyzed oxidative spiroannulation of 2-arylphenols with alkynes via a C-H activation/dearomatization strategy. J Org Chem. 2015;80(6):3349-56.
Zuo, Z., Yang, X., Liu, J., Nan, J., Bai, L., Wang, Y., & Luan, X. (2015). Ru(II)-catalyzed oxidative spiroannulation of 2-arylphenols with alkynes via a C-H activation/dearomatization strategy. The Journal of Organic Chemistry, 80(6), 3349-56. https://doi.org/10.1021/acs.joc.5b00316
Zuo Z, et al. Ru(II)-catalyzed Oxidative Spiroannulation of 2-arylphenols With Alkynes Via a C-H Activation/dearomatization Strategy. J Org Chem. 2015 Mar 20;80(6):3349-56. PubMed PMID: 25723782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ru(II)-catalyzed oxidative spiroannulation of 2-arylphenols with alkynes via a C-H activation/dearomatization strategy. AU - Zuo,Zhijun, AU - Yang,Xin, AU - Liu,Jingjing, AU - Nan,Jiang, AU - Bai,Lu, AU - Wang,Yaoyu, AU - Luan,Xinjun, Y1 - 2015/03/05/ PY - 2015/2/28/entrez PY - 2015/2/28/pubmed PY - 2015/2/28/medline SP - 3349 EP - 56 JF - The Journal of organic chemistry JO - J Org Chem VL - 80 IS - 6 N2 - An intermolecular spiroannulation reaction of appropriately substituted 2-arylphenols with internal alkynes has been developed by using a Ru(II) catalyst and an oxidant. This transformation was realized by a phenol-directed C-H activation, migratory insertion of the alkyne, and subsequent dearomatization of the phenolic ring, providing a broad range of highly functionalized spirocyclic compounds in moderate yields with high regioselectivity. SN - 1520-6904 UR - https://www.unboundmedicine.com/medline/citation/25723782/Ru_II__catalyzed_oxidative_spiroannulation_of_2_arylphenols_with_alkynes_via_a_C_H_activation/dearomatization_strategy_ DB - PRIME DP - Unbound Medicine ER -
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