Ru(II)-catalyzed oxidative spiroannulation of 2-arylphenols with alkynes via a C-H activation/dearomatization strategy.J Org Chem. 2015 Mar 20; 80(6):3349-56.JO
Abstract
An intermolecular spiroannulation reaction of appropriately substituted 2-arylphenols with internal alkynes has been developed by using a Ru(II) catalyst and an oxidant. This transformation was realized by a phenol-directed C-H activation, migratory insertion of the alkyne, and subsequent dearomatization of the phenolic ring, providing a broad range of highly functionalized spirocyclic compounds in moderate yields with high regioselectivity.
Links
Pub Type(s)
Journal Article
Language
eng
PubMed ID
25723782
Citation
Zuo, Zhijun, et al. "Ru(II)-catalyzed Oxidative Spiroannulation of 2-arylphenols With Alkynes Via a C-H Activation/dearomatization Strategy." The Journal of Organic Chemistry, vol. 80, no. 6, 2015, pp. 3349-56.
Zuo Z, Yang X, Liu J, et al. Ru(II)-catalyzed oxidative spiroannulation of 2-arylphenols with alkynes via a C-H activation/dearomatization strategy. J Org Chem. 2015;80(6):3349-56.
Zuo, Z., Yang, X., Liu, J., Nan, J., Bai, L., Wang, Y., & Luan, X. (2015). Ru(II)-catalyzed oxidative spiroannulation of 2-arylphenols with alkynes via a C-H activation/dearomatization strategy. The Journal of Organic Chemistry, 80(6), 3349-56. https://doi.org/10.1021/acs.joc.5b00316
Zuo Z, et al. Ru(II)-catalyzed Oxidative Spiroannulation of 2-arylphenols With Alkynes Via a C-H Activation/dearomatization Strategy. J Org Chem. 2015 Mar 20;80(6):3349-56. PubMed PMID: 25723782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Ru(II)-catalyzed oxidative spiroannulation of 2-arylphenols with alkynes via a C-H activation/dearomatization strategy.
AU - Zuo,Zhijun,
AU - Yang,Xin,
AU - Liu,Jingjing,
AU - Nan,Jiang,
AU - Bai,Lu,
AU - Wang,Yaoyu,
AU - Luan,Xinjun,
Y1 - 2015/03/05/
PY - 2015/2/28/entrez
PY - 2015/2/28/pubmed
PY - 2015/2/28/medline
SP - 3349
EP - 56
JF - The Journal of organic chemistry
JO - J Org Chem
VL - 80
IS - 6
N2 - An intermolecular spiroannulation reaction of appropriately substituted 2-arylphenols with internal alkynes has been developed by using a Ru(II) catalyst and an oxidant. This transformation was realized by a phenol-directed C-H activation, migratory insertion of the alkyne, and subsequent dearomatization of the phenolic ring, providing a broad range of highly functionalized spirocyclic compounds in moderate yields with high regioselectivity.
SN - 1520-6904
UR - https://www.unboundmedicine.com/medline/citation/25723782/Ru_II__catalyzed_oxidative_spiroannulation_of_2_arylphenols_with_alkynes_via_a_C_H_activation/dearomatization_strategy_
DB - PRIME
DP - Unbound Medicine
ER -
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