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Burden of norovirus in healthcare facilities and strategies for outbreak control.
J Hosp Infect. 2015 Apr; 89(4):296-301.JH

Abstract

Norovirus is the most frequently occurring cause of community-acquired acute gastroenteritis in people of all ages. It is also one of the most frequent causes of outbreaks in healthcare settings, affecting both long-term care facilities and acute care hospitals. Whereas norovirus gastroenteritis is typically mild and resolves without medical attention, healthcare-associated infections often affect vulnerable populations, resulting in severe infections and disruption of healthcare services. Globally, most norovirus outbreaks in hospitals and residential care institutions are associated with genogroup II type 4 (GII.4) strains. Recent data demonstrate that excess mortality occurs during outbreak periods in healthcare facilities. Nosocomial outbreaks can result in large economic and societal costs. Current control measures for norovirus are largely based on general infection control principles, and treatment is mainly supportive and non-specific. While neither vaccines nor antiviral agents are currently available, both are being developed with encouraging results.

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Authors+Show Affiliations

Kambhampati A
Centers for Disease Control and Prevention, Atlanta, GA, USA.
Koopmans M
National Institute for Public Health and the Environment, Bilthoven, The Netherlands; Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
Lopman BA
Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: blopman@cdc.gov.

MeSH

Caliciviridae InfectionsCross InfectionDisease OutbreaksGastroenteritisGenotypeHealth FacilitiesHumansInfection ControlNorovirus

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

25726433

Citation

Kambhampati, A, et al. "Burden of Norovirus in Healthcare Facilities and Strategies for Outbreak Control." The Journal of Hospital Infection, vol. 89, no. 4, 2015, pp. 296-301.
Kambhampati A, Koopmans M, Lopman BA. Burden of norovirus in healthcare facilities and strategies for outbreak control. J Hosp Infect. 2015;89(4):296-301.
Kambhampati, A., Koopmans, M., & Lopman, B. A. (2015). Burden of norovirus in healthcare facilities and strategies for outbreak control. The Journal of Hospital Infection, 89(4), 296-301. https://doi.org/10.1016/j.jhin.2015.01.011
Kambhampati A, Koopmans M, Lopman BA. Burden of Norovirus in Healthcare Facilities and Strategies for Outbreak Control. J Hosp Infect. 2015;89(4):296-301. PubMed PMID: 25726433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Burden of norovirus in healthcare facilities and strategies for outbreak control. AU - Kambhampati,A, AU - Koopmans,M, AU - Lopman,B A, Y1 - 2015/02/04/ PY - 2014/12/04/received PY - 2015/01/06/accepted PY - 2015/3/2/entrez PY - 2015/3/3/pubmed PY - 2015/12/23/medline KW - Antiviral agents KW - Gastroenteritis KW - Genogroup II type 4 KW - Infection control KW - Norovirus SP - 296 EP - 301 JF - The Journal of hospital infection JO - J Hosp Infect VL - 89 IS - 4 N2 - Norovirus is the most frequently occurring cause of community-acquired acute gastroenteritis in people of all ages. It is also one of the most frequent causes of outbreaks in healthcare settings, affecting both long-term care facilities and acute care hospitals. Whereas norovirus gastroenteritis is typically mild and resolves without medical attention, healthcare-associated infections often affect vulnerable populations, resulting in severe infections and disruption of healthcare services. Globally, most norovirus outbreaks in hospitals and residential care institutions are associated with genogroup II type 4 (GII.4) strains. Recent data demonstrate that excess mortality occurs during outbreak periods in healthcare facilities. Nosocomial outbreaks can result in large economic and societal costs. Current control measures for norovirus are largely based on general infection control principles, and treatment is mainly supportive and non-specific. While neither vaccines nor antiviral agents are currently available, both are being developed with encouraging results. SN - 1532-2939 UR - https://www.unboundmedicine.com/medline/citation/25726433/Burden_of_norovirus_in_healthcare_facilities_and_strategies_for_outbreak_control_ DB - PRIME DP - Unbound Medicine ER -