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Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects.
J Pharmacol Sci 2015; 127(2):217-22JP

Abstract

Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in healthy subjects. A double-blind, placebo-controlled, crossover study was performed in 27 healthy volunteers. A cup of either caffeinated or decaffeinated coffee was drunk by the subjects, and reactive hyperemia of finger blood flow was assessed by laser Doppler flowmetry. In an interval of more than 2 days, the same experimental protocol was repeated with another coffee in a crossover manner. Caffeinated coffee intake slightly but significantly elevated blood pressure and decreased finger blood flow as compared with decaffeinated coffee intake. There was no significant difference in heart rate between caffeinated and decaffeinated coffee intake. Importantly, caffeinated coffee intake significantly enhanced post-occlusive reactive hyperemia of finger blood flow, an index of microvascular endothelial function, compared with decaffeinated coffee intake. These results provide the first evidence that caffeine contained in a cup of coffee enhances microvascular function in healthy individuals.

Authors+Show Affiliations

Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. Electronic address: noguchi@med.u-ryukyu.ac.jp.Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Second Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Neurosurgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Third Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. Electronic address: tsutsui@med.u-ryukyu.ac.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25727960

Citation

Noguchi, Katsuhiko, et al. "Effect of Caffeine Contained in a Cup of Coffee On Microvascular Function in Healthy Subjects." Journal of Pharmacological Sciences, vol. 127, no. 2, 2015, pp. 217-22.
Noguchi K, Matsuzaki T, Sakanashi M, et al. Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects. J Pharmacol Sci. 2015;127(2):217-22.
Noguchi, K., Matsuzaki, T., Sakanashi, M., Hamadate, N., Uchida, T., Kina-Tanada, M., ... Tsutsui, M. (2015). Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects. Journal of Pharmacological Sciences, 127(2), pp. 217-22. doi:10.1016/j.jphs.2015.01.003.
Noguchi K, et al. Effect of Caffeine Contained in a Cup of Coffee On Microvascular Function in Healthy Subjects. J Pharmacol Sci. 2015;127(2):217-22. PubMed PMID: 25727960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of caffeine contained in a cup of coffee on microvascular function in healthy subjects. AU - Noguchi,Katsuhiko, AU - Matsuzaki,Toshihiro, AU - Sakanashi,Mayuko, AU - Hamadate,Naobumi, AU - Uchida,Taro, AU - Kina-Tanada,Mika, AU - Kubota,Haruaki, AU - Nakasone,Junko, AU - Sakanashi,Matao, AU - Ueda,Shinichiro, AU - Masuzaki,Hiroaki, AU - Ishiuchi,Shogo, AU - Ohya,Yusuke, AU - Tsutsui,Masato, Y1 - 2015/01/28/ PY - 2014/10/16/received PY - 2014/12/26/revised PY - 2015/01/13/accepted PY - 2015/3/3/entrez PY - 2015/3/3/pubmed PY - 2016/3/2/medline KW - Caffeine KW - Coffee KW - Endothelial function KW - Laser-Doppler flowmetry KW - Microcirculation SP - 217 EP - 22 JF - Journal of pharmacological sciences JO - J. Pharmacol. Sci. VL - 127 IS - 2 N2 - Recent epidemiological studies have demonstrated that coffee drinking is associated with reduced mortality of cardiovascular disease. However, its precise mechanisms remain to be clarified. In this study, we examined whether single ingestion of caffeine contained in a cup of coffee improves microvascular function in healthy subjects. A double-blind, placebo-controlled, crossover study was performed in 27 healthy volunteers. A cup of either caffeinated or decaffeinated coffee was drunk by the subjects, and reactive hyperemia of finger blood flow was assessed by laser Doppler flowmetry. In an interval of more than 2 days, the same experimental protocol was repeated with another coffee in a crossover manner. Caffeinated coffee intake slightly but significantly elevated blood pressure and decreased finger blood flow as compared with decaffeinated coffee intake. There was no significant difference in heart rate between caffeinated and decaffeinated coffee intake. Importantly, caffeinated coffee intake significantly enhanced post-occlusive reactive hyperemia of finger blood flow, an index of microvascular endothelial function, compared with decaffeinated coffee intake. These results provide the first evidence that caffeine contained in a cup of coffee enhances microvascular function in healthy individuals. SN - 1347-8648 UR - https://www.unboundmedicine.com/medline/citation/25727960/Effect_of_caffeine_contained_in_a_cup_of_coffee_on_microvascular_function_in_healthy_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1347-8613(15)00006-7 DB - PRIME DP - Unbound Medicine ER -