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Filamentous fungal infections of the cornea: a global overview of epidemiology and drug sensitivity.
Mycoses. 2015 Apr; 58(4):243-60.M

Abstract

Fungal keratitis is a serious suppurative, usually ulcerative corneal infection which may result in blindness or reduced vision. Epidemiological studies indicate that the occurrence of fungal keratitis is higher in warm, humid regions with agricultural economy. The most frequent filamentous fungal genera among the causal agents are Fusarium, Aspergillus and Curvularia. A more successful therapy of fungal keratitis relies on precise identification of the pathogen to the species level using molecular tools. As the sequence analysis of the internal transcribed spacer (ITS) region of the ribosomal RNA gene cluster (rDNA) is not discriminative enough to reveal a species-level diagnosis for several filamentous fungal species highly relevant in keratitis infections, analysis of other loci is also required for an exact diagnosis. Molecular identifications may also reveal the involvement of fungal species which were not previously reported from corneal infections. The routinely applied chemotherapy of fungal keratitis is based on the topical and systemic administration of polyenes and azole compounds. Antifungal susceptibility testing of the causal agents is of special importance due to the emergence and spread of resistance. Testing the applicability of further available antifungals and screening for new, potential compounds for the therapy of fungal keratitis are of highlighted interest.

Authors+Show Affiliations

Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25728367

Citation

Kredics, László, et al. "Filamentous Fungal Infections of the Cornea: a Global Overview of Epidemiology and Drug Sensitivity." Mycoses, vol. 58, no. 4, 2015, pp. 243-60.
Kredics L, Narendran V, Shobana CS, et al. Filamentous fungal infections of the cornea: a global overview of epidemiology and drug sensitivity. Mycoses. 2015;58(4):243-60.
Kredics, L., Narendran, V., Shobana, C. S., Vágvölgyi, C., & Manikandan, P. (2015). Filamentous fungal infections of the cornea: a global overview of epidemiology and drug sensitivity. Mycoses, 58(4), 243-60. https://doi.org/10.1111/myc.12306
Kredics L, et al. Filamentous Fungal Infections of the Cornea: a Global Overview of Epidemiology and Drug Sensitivity. Mycoses. 2015;58(4):243-60. PubMed PMID: 25728367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Filamentous fungal infections of the cornea: a global overview of epidemiology and drug sensitivity. AU - Kredics,László, AU - Narendran,Venkatapathy, AU - Shobana,Coimbatore Subramanian, AU - Vágvölgyi,Csaba, AU - Manikandan,Palanisamy, AU - ,, Y1 - 2015/02/27/ PY - 2014/12/21/received PY - 2015/01/27/revised PY - 2015/02/13/accepted PY - 2015/3/3/entrez PY - 2015/3/3/pubmed PY - 2015/12/17/medline KW - Aspergillus KW - Curvularia KW - Eye infections KW - Fusarium KW - antifungal susceptibility KW - epidemiology KW - keratitis KW - molecular identification SP - 243 EP - 60 JF - Mycoses JO - Mycoses VL - 58 IS - 4 N2 - Fungal keratitis is a serious suppurative, usually ulcerative corneal infection which may result in blindness or reduced vision. Epidemiological studies indicate that the occurrence of fungal keratitis is higher in warm, humid regions with agricultural economy. The most frequent filamentous fungal genera among the causal agents are Fusarium, Aspergillus and Curvularia. A more successful therapy of fungal keratitis relies on precise identification of the pathogen to the species level using molecular tools. As the sequence analysis of the internal transcribed spacer (ITS) region of the ribosomal RNA gene cluster (rDNA) is not discriminative enough to reveal a species-level diagnosis for several filamentous fungal species highly relevant in keratitis infections, analysis of other loci is also required for an exact diagnosis. Molecular identifications may also reveal the involvement of fungal species which were not previously reported from corneal infections. The routinely applied chemotherapy of fungal keratitis is based on the topical and systemic administration of polyenes and azole compounds. Antifungal susceptibility testing of the causal agents is of special importance due to the emergence and spread of resistance. Testing the applicability of further available antifungals and screening for new, potential compounds for the therapy of fungal keratitis are of highlighted interest. SN - 1439-0507 UR - https://www.unboundmedicine.com/medline/citation/25728367/Filamentous_fungal_infections_of_the_cornea:_a_global_overview_of_epidemiology_and_drug_sensitivity_ L2 - https://doi.org/10.1111/myc.12306 DB - PRIME DP - Unbound Medicine ER -