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Necrobiosis lipoidica: a descriptive study of 35 cases.
Actas Dermosifiliogr. 2015 Jun; 106(5):402-7.AD

Abstract

INTRODUCTION AND OBJECTIVES

Necrobiosis lipoidica (NL) is a chronic idiopathic granulomatous disease considered to occur in association with diabetes mellitus. Data on the frequency of this association, however, are inconsistent. Our aim was to retrospectively analyze the clinical characteristics of patients diagnosed with NL at our hospital and to investigate the association with diabetes mellitus and other diseases.

MATERIAL AND METHODS

We performed a chart review of all patients with a clinical and histologic diagnosis of NL treated and followed in the dermatology department of Hospital de Bellvitge in Barcelona, Spain between 1987 and 2013.

RESULTS

Thirty-five patients (6 men and 29 women with a mean age of 47.20 years) were diagnosed with NL in the study period. At the time of diagnosis, 31 patients had pretibial lesions. Thirteen patients (37%) had a single lesion at diagnosis, and the mean number of lesions was 3.37. Twenty-three patients (65.71%) had diabetes mellitus (type 1 in 10 cases and type 2 in 13). In 20 patients, onset of diabetes preceded that of NL by a mean of 135.70 months. The 2 conditions were diagnosed simultaneously in 3 patients. None of the 35 patients developed diabetes mellitus during follow-up. Six patients had hypothyroidism, and 4 of these also had type 1 diabetes.

CONCLUSIONS

NL is frequently associated with type 1 and 2 diabetes. Although diabetes tends to develop before NL, it can occur simultaneously.

Authors+Show Affiliations

Servicio de Dermatología, Hospital Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, Barcelona, España. Electronic address: jmarcoval@bellvitgehospital.cat.Servicio de Dermatología, Hospital Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, Barcelona, España.Servicio de Dermatología, Hospital Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, Barcelona, España.Servicio de Dermatología, Hospital Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, Barcelona, España.Servicio de Dermatología, Hospital Universitari de Bellvitge, IDIBELL, Universitat de Barcelona, Barcelona, España.

Pub Type(s)

Journal Article

Language

eng spa

PubMed ID

25728565

Citation

Marcoval, J, et al. "Necrobiosis Lipoidica: a Descriptive Study of 35 Cases." Actas Dermo-sifiliograficas, vol. 106, no. 5, 2015, pp. 402-7.
Marcoval J, Gómez-Armayones S, Valentí-Medina F, et al. Necrobiosis lipoidica: a descriptive study of 35 cases. Actas Dermosifiliogr. 2015;106(5):402-7.
Marcoval, J., Gómez-Armayones, S., Valentí-Medina, F., Bonfill-Ortí, M., & Martínez-Molina, L. (2015). Necrobiosis lipoidica: a descriptive study of 35 cases. Actas Dermo-sifiliograficas, 106(5), 402-7. https://doi.org/10.1016/j.ad.2015.01.004
Marcoval J, et al. Necrobiosis Lipoidica: a Descriptive Study of 35 Cases. Actas Dermosifiliogr. 2015;106(5):402-7. PubMed PMID: 25728565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Necrobiosis lipoidica: a descriptive study of 35 cases. AU - Marcoval,J, AU - Gómez-Armayones,S, AU - Valentí-Medina,F, AU - Bonfill-Ortí,M, AU - Martínez-Molina,L, Y1 - 2015/02/26/ PY - 2014/07/15/received PY - 2014/12/30/revised PY - 2015/01/11/accepted PY - 2015/3/3/entrez PY - 2015/3/3/pubmed PY - 2017/2/28/medline KW - Diabetes mellitus KW - Granuloma annulare KW - Granuloma anular KW - Hipotiroidismo KW - Hypothyroidism KW - Necrobiosis lipoidica KW - Necrobiosis lipoídica SP - 402 EP - 7 JF - Actas dermo-sifiliograficas JO - Actas Dermosifiliogr VL - 106 IS - 5 N2 - INTRODUCTION AND OBJECTIVES: Necrobiosis lipoidica (NL) is a chronic idiopathic granulomatous disease considered to occur in association with diabetes mellitus. Data on the frequency of this association, however, are inconsistent. Our aim was to retrospectively analyze the clinical characteristics of patients diagnosed with NL at our hospital and to investigate the association with diabetes mellitus and other diseases. MATERIAL AND METHODS: We performed a chart review of all patients with a clinical and histologic diagnosis of NL treated and followed in the dermatology department of Hospital de Bellvitge in Barcelona, Spain between 1987 and 2013. RESULTS: Thirty-five patients (6 men and 29 women with a mean age of 47.20 years) were diagnosed with NL in the study period. At the time of diagnosis, 31 patients had pretibial lesions. Thirteen patients (37%) had a single lesion at diagnosis, and the mean number of lesions was 3.37. Twenty-three patients (65.71%) had diabetes mellitus (type 1 in 10 cases and type 2 in 13). In 20 patients, onset of diabetes preceded that of NL by a mean of 135.70 months. The 2 conditions were diagnosed simultaneously in 3 patients. None of the 35 patients developed diabetes mellitus during follow-up. Six patients had hypothyroidism, and 4 of these also had type 1 diabetes. CONCLUSIONS: NL is frequently associated with type 1 and 2 diabetes. Although diabetes tends to develop before NL, it can occur simultaneously. SN - 1578-2190 UR - https://www.unboundmedicine.com/medline/citation/25728565/Necrobiosis_lipoidica:_a_descriptive_study_of_35_cases_ L2 - http://www.elsevier.es/en/linksolver/pdf/pii/S0001-7310(15)00051-4 DB - PRIME DP - Unbound Medicine ER -