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Association between serum long-chain n-3 and n-6 polyunsaturated fatty acid profiles and glomerular filtration rate assessed by serum creatinine and cystatin C levels in Japanese community-dwellers.
J Epidemiol. 2015; 25(4):303-11.JE

Abstract

BACKGROUND

Plasma concentration of n-3 polyunsaturated fatty acids (PUFAs) has been reported to be associated with renal function in Western populations. However, few studies have investigated the association between serum long-chain n-3 and n-6 PUFA profiles and renal function in a Japanese population with high marine-derived long-chain n-3 PUFA intake.

METHODS

A cross-sectional study was performed in 549 Japanese rural community-dwellers aged 40 to 64 years. In adjusted analysis of covariance, we assessed the relationship between estimated glomerular filtration rate (eGFR) and tertiles of serum long-chain n-3 and n-6 PUFA profiles ([eicosapentaenoic acid {EPA} + docosahexaenoic acid {DHA}]:arachidonic acid [AA]). GFR was estimated by Japanese specific equations using serum creatinine and cystatin C (eGFRcre and eGFRcys). Using multivariate-adjusted linear regression models, we also assessed the relationships between eGFRs and several n-3 and n-6 PUFAs, which have been suggested to be associated with renal function.

RESULTS

In all participants, higher dietary fish intake as assessed by a semi-quantitative questionnaire was associated with higher serum value of (EPA+DHA):AA. Participants in the higher (EPA+DHA):AA tertiles had non-significantly higher eGFRcre and significantly higher eGFRcys (P = 0.016). In addition, eGFRcys in T2+T3 of (EPA+DHA):AA was significantly higher than that in T1 (adjusted mean eGFRcys, T1: 87 ml/min/1.73 m(2), T2+T3: 91 ml/min/1.73 m(2); P < 0.01). Among the PUFAs, only (EPA+DHA) was significantly associated with eGFRcys.

CONCLUSIONS

Serum (EPA+DHA):AA, which reflects an individual's fish intake, might be associated with eGFRcys in Japanese community-dwellers.

Authors+Show Affiliations

Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo; Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25728619

Citation

Higashiyama, Aya, et al. "Association Between Serum Long-chain N-3 and N-6 Polyunsaturated Fatty Acid Profiles and Glomerular Filtration Rate Assessed By Serum Creatinine and Cystatin C Levels in Japanese Community-dwellers." Journal of Epidemiology, vol. 25, no. 4, 2015, pp. 303-11.
Higashiyama A, Kubota Y, Marumo M, et al. Association between serum long-chain n-3 and n-6 polyunsaturated fatty acid profiles and glomerular filtration rate assessed by serum creatinine and cystatin C levels in Japanese community-dwellers. J Epidemiol. 2015;25(4):303-11.
Higashiyama, A., Kubota, Y., Marumo, M., Konishi, M., Yamashita, Y., Nishimura, K., Fukuda, Y., Okamura, T., & Wakabayashi, I. (2015). Association between serum long-chain n-3 and n-6 polyunsaturated fatty acid profiles and glomerular filtration rate assessed by serum creatinine and cystatin C levels in Japanese community-dwellers. Journal of Epidemiology, 25(4), 303-11. https://doi.org/10.2188/jea.JE20140093
Higashiyama A, et al. Association Between Serum Long-chain N-3 and N-6 Polyunsaturated Fatty Acid Profiles and Glomerular Filtration Rate Assessed By Serum Creatinine and Cystatin C Levels in Japanese Community-dwellers. J Epidemiol. 2015;25(4):303-11. PubMed PMID: 25728619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum long-chain n-3 and n-6 polyunsaturated fatty acid profiles and glomerular filtration rate assessed by serum creatinine and cystatin C levels in Japanese community-dwellers. AU - Higashiyama,Aya, AU - Kubota,Yoshimi, AU - Marumo,Mikio, AU - Konishi,Masami, AU - Yamashita,Yoshiko, AU - Nishimura,Kunihiro, AU - Fukuda,Yoshihiro, AU - Okamura,Tomonori, AU - Wakabayashi,Ichiro, Y1 - 2015/02/28/ PY - 2015/3/3/entrez PY - 2015/3/3/pubmed PY - 2015/6/3/medline SP - 303 EP - 11 JF - Journal of epidemiology JO - J Epidemiol VL - 25 IS - 4 N2 - BACKGROUND: Plasma concentration of n-3 polyunsaturated fatty acids (PUFAs) has been reported to be associated with renal function in Western populations. However, few studies have investigated the association between serum long-chain n-3 and n-6 PUFA profiles and renal function in a Japanese population with high marine-derived long-chain n-3 PUFA intake. METHODS: A cross-sectional study was performed in 549 Japanese rural community-dwellers aged 40 to 64 years. In adjusted analysis of covariance, we assessed the relationship between estimated glomerular filtration rate (eGFR) and tertiles of serum long-chain n-3 and n-6 PUFA profiles ([eicosapentaenoic acid {EPA} + docosahexaenoic acid {DHA}]:arachidonic acid [AA]). GFR was estimated by Japanese specific equations using serum creatinine and cystatin C (eGFRcre and eGFRcys). Using multivariate-adjusted linear regression models, we also assessed the relationships between eGFRs and several n-3 and n-6 PUFAs, which have been suggested to be associated with renal function. RESULTS: In all participants, higher dietary fish intake as assessed by a semi-quantitative questionnaire was associated with higher serum value of (EPA+DHA):AA. Participants in the higher (EPA+DHA):AA tertiles had non-significantly higher eGFRcre and significantly higher eGFRcys (P = 0.016). In addition, eGFRcys in T2+T3 of (EPA+DHA):AA was significantly higher than that in T1 (adjusted mean eGFRcys, T1: 87 ml/min/1.73 m(2), T2+T3: 91 ml/min/1.73 m(2); P < 0.01). Among the PUFAs, only (EPA+DHA) was significantly associated with eGFRcys. CONCLUSIONS: Serum (EPA+DHA):AA, which reflects an individual's fish intake, might be associated with eGFRcys in Japanese community-dwellers. SN - 1349-9092 UR - https://www.unboundmedicine.com/medline/citation/25728619/Association_between_serum_long_chain_n_3_and_n_6_polyunsaturated_fatty_acid_profiles_and_glomerular_filtration_rate_assessed_by_serum_creatinine_and_cystatin_C_levels_in_Japanese_community_dwellers_ L2 - https://dx.doi.org/10.2188/jea.JE20140093 DB - PRIME DP - Unbound Medicine ER -