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Application of the ratio difference spectrophotometry to the determination of ibuprofen and famotidine in their combined dosage form: comparison with previously published spectrophotometric methods.
Spectrochim Acta A Mol Biomol Spectrosc. 2015 May 15; 143:251-5.SA

Abstract

Ratio difference spectrophotometric method was developed for the determination of ibuprofen and famotidine in their mixture form. Ibuprofen and famotidine were determined in the presence of each other by the ratio difference spectrophotometric (RD) method where linearity was obtained from 50 to 600μg/mL and 2.5 to 25μg/mL for ibuprofen and famotidine, respectively. The suggested method was validated according to ICH guidelines and successfully applied for the analysis of ibuprofen and famotidine in their pharmaceutical dosage forms without interference from any additives or excipients.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zaazaa HE
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.
Elzanfaly ES
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.
Soudi AT
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt. Electronic address: ayoosh_soudi@yahoo.com.
Salem MY
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.

MeSH

Anti-Inflammatory Agents, Non-SteroidalDrug CombinationsFamotidineIbuprofenSpectrophotometry, Ultraviolet

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25733252

Citation

Zaazaa, Hala E., et al. "Application of the Ratio Difference Spectrophotometry to the Determination of Ibuprofen and Famotidine in Their Combined Dosage Form: Comparison With Previously Published Spectrophotometric Methods." Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, vol. 143, 2015, pp. 251-5.
Zaazaa HE, Elzanfaly ES, Soudi AT, et al. Application of the ratio difference spectrophotometry to the determination of ibuprofen and famotidine in their combined dosage form: comparison with previously published spectrophotometric methods. Spectrochim Acta A Mol Biomol Spectrosc. 2015;143:251-5.
Zaazaa, H. E., Elzanfaly, E. S., Soudi, A. T., & Salem, M. Y. (2015). Application of the ratio difference spectrophotometry to the determination of ibuprofen and famotidine in their combined dosage form: comparison with previously published spectrophotometric methods. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 143, 251-5. https://doi.org/10.1016/j.saa.2015.02.050
Zaazaa HE, et al. Application of the Ratio Difference Spectrophotometry to the Determination of Ibuprofen and Famotidine in Their Combined Dosage Form: Comparison With Previously Published Spectrophotometric Methods. Spectrochim Acta A Mol Biomol Spectrosc. 2015 May 15;143:251-5. PubMed PMID: 25733252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Application of the ratio difference spectrophotometry to the determination of ibuprofen and famotidine in their combined dosage form: comparison with previously published spectrophotometric methods. AU - Zaazaa,Hala E, AU - Elzanfaly,Eman S, AU - Soudi,Aya T, AU - Salem,Maissa Y, Y1 - 2015/02/19/ PY - 2014/11/21/received PY - 2015/02/10/revised PY - 2015/02/12/accepted PY - 2015/3/4/entrez PY - 2015/3/4/pubmed PY - 2016/2/9/medline KW - Famotidine KW - Ibuprofen KW - Ratio difference (RD) SP - 251 EP - 5 JF - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy JO - Spectrochim Acta A Mol Biomol Spectrosc VL - 143 N2 - Ratio difference spectrophotometric method was developed for the determination of ibuprofen and famotidine in their mixture form. Ibuprofen and famotidine were determined in the presence of each other by the ratio difference spectrophotometric (RD) method where linearity was obtained from 50 to 600μg/mL and 2.5 to 25μg/mL for ibuprofen and famotidine, respectively. The suggested method was validated according to ICH guidelines and successfully applied for the analysis of ibuprofen and famotidine in their pharmaceutical dosage forms without interference from any additives or excipients. SN - 1873-3557 UR - https://www.unboundmedicine.com/medline/citation/25733252/Application_of_the_ratio_difference_spectrophotometry_to_the_determination_of_ibuprofen_and_famotidine_in_their_combined_dosage_form:_comparison_with_previously_published_spectrophotometric_methods_ DB - PRIME DP - Unbound Medicine ER -