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Effect of recombinant human erythropoietin on mitomycin C-induced oxidative stress and genotoxicity in rat kidney and heart tissues.
Hum Exp Toxicol. 2016 Jan; 35(1):53-62.HE

Abstract

Mitomycin C (MMC) is an antineoplastic agent used for the treatment of several human malignancies. Nevertheless, the prolonged use of the drug may result in a serious heart and kidney injuries. Recombinant human erythropoietin (rhEPO) has recently been shown to exert an important cytoprotective effect in experimental brain injury and ischemic acute renal failure. The aim of the present work is to investigate the cardioprotective and renoprotective effects of rhEPO against MMC-induced oxidative damage and genotoxicity. Our results showed that MMC induced oxidative stress and DNA damage. rhEPO administration in any treatment conditions decreased oxidative damage induced by MMC. It reduced malondialdehyde and protein carbonyl levels. rhEPO ameliorated reduced glutathione plus oxidized glutathione modulation and the increased catalase activity after MMC treatment. Furthermore, rhEPO restored DNA damage caused by MMC. We concluded that rhEPO administration especially in pretreatment condition protected rats against MMC-induced heart and renal oxidative stress and genotoxicity.

Authors+Show Affiliations

Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.Department of Nephrology, Dialysis and Transplant, University Hospital of Sahloul, Sousse, Tunisia.Department of Nephrology, Dialysis and Transplant, University Hospital of Sahloul, Sousse, Tunisia.Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia hassen.bacha@fmdm.rnu.tn.Laboratory of Research on Biologically Compatible Compounds, Faculty of Dentistry, Monastir, Tunisia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25733728

Citation

Rjiba-Touati, K, et al. "Effect of Recombinant Human Erythropoietin On Mitomycin C-induced Oxidative Stress and Genotoxicity in Rat Kidney and Heart Tissues." Human & Experimental Toxicology, vol. 35, no. 1, 2016, pp. 53-62.
Rjiba-Touati K, Ayed-Boussema I, Guedri Y, et al. Effect of recombinant human erythropoietin on mitomycin C-induced oxidative stress and genotoxicity in rat kidney and heart tissues. Hum Exp Toxicol. 2016;35(1):53-62.
Rjiba-Touati, K., Ayed-Boussema, I., Guedri, Y., Achour, A., Bacha, H., & Abid-Essefi, S. (2016). Effect of recombinant human erythropoietin on mitomycin C-induced oxidative stress and genotoxicity in rat kidney and heart tissues. Human & Experimental Toxicology, 35(1), 53-62. https://doi.org/10.1177/0960327115577521
Rjiba-Touati K, et al. Effect of Recombinant Human Erythropoietin On Mitomycin C-induced Oxidative Stress and Genotoxicity in Rat Kidney and Heart Tissues. Hum Exp Toxicol. 2016;35(1):53-62. PubMed PMID: 25733728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of recombinant human erythropoietin on mitomycin C-induced oxidative stress and genotoxicity in rat kidney and heart tissues. AU - Rjiba-Touati,K, AU - Ayed-Boussema,I, AU - Guedri,Y, AU - Achour,A, AU - Bacha,H, AU - Abid-Essefi,S, Y1 - 2015/03/02/ PY - 2015/3/4/entrez PY - 2015/3/4/pubmed PY - 2016/9/30/medline KW - antigenotoxic effect KW - antioxidant effect KW - mitomycin C KW - rhEPO SP - 53 EP - 62 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 35 IS - 1 N2 - Mitomycin C (MMC) is an antineoplastic agent used for the treatment of several human malignancies. Nevertheless, the prolonged use of the drug may result in a serious heart and kidney injuries. Recombinant human erythropoietin (rhEPO) has recently been shown to exert an important cytoprotective effect in experimental brain injury and ischemic acute renal failure. The aim of the present work is to investigate the cardioprotective and renoprotective effects of rhEPO against MMC-induced oxidative damage and genotoxicity. Our results showed that MMC induced oxidative stress and DNA damage. rhEPO administration in any treatment conditions decreased oxidative damage induced by MMC. It reduced malondialdehyde and protein carbonyl levels. rhEPO ameliorated reduced glutathione plus oxidized glutathione modulation and the increased catalase activity after MMC treatment. Furthermore, rhEPO restored DNA damage caused by MMC. We concluded that rhEPO administration especially in pretreatment condition protected rats against MMC-induced heart and renal oxidative stress and genotoxicity. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/25733728/Effect_of_recombinant_human_erythropoietin_on_mitomycin_C_induced_oxidative_stress_and_genotoxicity_in_rat_kidney_and_heart_tissues_ L2 - https://journals.sagepub.com/doi/10.1177/0960327115577521?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -