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[Calciphylaxis].
Dtsch Med Wochenschr 2015; 140(5):347-51DM

Abstract

Calciphylaxis (calcific uremic arteriolopathy, CUA) is a rare disease at the interface of nephrology, dermatology and cardiovascular medicine. CUA typically occurs in chronic dialysis patients. However, anecdotal reports also exist about cases in patients without relevant kidney disease. Clinically CUA is characterized by the stepwise development of superficial painful sensations and cutaneous lesions similar to livedo reticularis. Skin necrosis and ulceration represent the full-blown, "late" clinical picture. Panniculitis and circumferential calcification of cutaneous arterioles dominate the histological picture together with endothelial detachment. The prognosis of CUA is poor due to high morbidity and mortality largely resulting from underlying cardiovascular disease or septicemia. The aetiology of CUA is incompletely understood. Previous oral anticoagulation with vitamin K antagonists is considered as a risk factor. Unfortunately, evidence-based therapeutic options are absent, since controlled treatment trials have not been conducted yet. Long-term pain and wound management are mandatory. In the absence of controlled prospective trials registry studies such as the German CUA registry (www.calciphylaxis.net) support data collecting and analysis upon good clinical practice and may stimulate exchange of expertise and networking.

Authors+Show Affiliations

Klinik für Kardiologie, Universitätsklinikum der RWTH Aachen.Dialysezentrum Zwickau.Virtuelle Horizonte, Gesellschaft für Neue Medien e.K, Coburg.III. Medizinische Klinik (Nephrologie), Klinikum Coburg.

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

25734678

Citation

Brandenburg, Vincent M., et al. "[Calciphylaxis]." Deutsche Medizinische Wochenschrift (1946), vol. 140, no. 5, 2015, pp. 347-51.
Brandenburg VM, Martin H, Sohn CM, et al. [Calciphylaxis]. Dtsch Med Wochenschr. 2015;140(5):347-51.
Brandenburg, V. M., Martin, H., Sohn, C. M., & Ketteler, M. (2015). [Calciphylaxis]. Deutsche Medizinische Wochenschrift (1946), 140(5), pp. 347-51. doi:10.1055/s-0041-100834.
Brandenburg VM, et al. [Calciphylaxis]. Dtsch Med Wochenschr. 2015;140(5):347-51. PubMed PMID: 25734678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Calciphylaxis]. AU - Brandenburg,Vincent M, AU - Martin,Heike, AU - Sohn,Christoph Müller Philipps, AU - Ketteler,Markus, Y1 - 2015/03/03/ PY - 2015/3/4/entrez PY - 2015/3/4/pubmed PY - 2015/4/29/medline SP - 347 EP - 51 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch. Med. Wochenschr. VL - 140 IS - 5 N2 - Calciphylaxis (calcific uremic arteriolopathy, CUA) is a rare disease at the interface of nephrology, dermatology and cardiovascular medicine. CUA typically occurs in chronic dialysis patients. However, anecdotal reports also exist about cases in patients without relevant kidney disease. Clinically CUA is characterized by the stepwise development of superficial painful sensations and cutaneous lesions similar to livedo reticularis. Skin necrosis and ulceration represent the full-blown, "late" clinical picture. Panniculitis and circumferential calcification of cutaneous arterioles dominate the histological picture together with endothelial detachment. The prognosis of CUA is poor due to high morbidity and mortality largely resulting from underlying cardiovascular disease or septicemia. The aetiology of CUA is incompletely understood. Previous oral anticoagulation with vitamin K antagonists is considered as a risk factor. Unfortunately, evidence-based therapeutic options are absent, since controlled treatment trials have not been conducted yet. Long-term pain and wound management are mandatory. In the absence of controlled prospective trials registry studies such as the German CUA registry (www.calciphylaxis.net) support data collecting and analysis upon good clinical practice and may stimulate exchange of expertise and networking. SN - 1439-4413 UR - https://www.unboundmedicine.com/medline/citation/25734678/[Calciphylaxis]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0041-100834 DB - PRIME DP - Unbound Medicine ER -