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Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead.
J Occup Health. 2015; 57(2):91-9.JO

Abstract

OBJECTIVES

Occupational exposure to lead may produce kidney damage, but existing data on the dose range associated with nephrotoxicity are inconclusive. We here assessed renal function under conditions of low to moderate lead exposure using renal scintigraphy.

METHODS

Fifty-three male foundrymen (exposed group) and fourty male office workers (control group) from a steel plant were included in the study. Glomerular and tubular renal function were assessed by means of (99m)Tc-DTPA and (99m)Tc-EC clearance, respectively. Urinary markers of glomerular dysfunction (albumin) and tubular damage (α1-microglobulin (α1M), β2-microglobulin (β2M), retinol-binding protein (RBP), N-acetyl-β-glucosaminidase (NAG) activity) were determined using latex beads tests or colorimetry. The lead concentration in blood was measured with atomic absorption spectrometry.

RESULTS

The blood lead concentrations were 145.8 (121.3-175.3) and 39.3 (35.1-44.1) µg/l (geometric mean, 95(th) CI, p<0.001) in the exposed and control groups, respectively. Subjects exposed to lead presented with increased (99m)Tc-DTPA clearance (158.3 (148.4-168.8) vs. 135.9 (127.9-144.4) ml/min; p<0.01) and urinary albumin excretion (7.61 (6.28-9.22) vs. 4.78 (4.05-5.65) mg/g creatinine; p<0.001). (99m)Tc-EC clearance and excretion of α1M, β2M, RBP and NAG were not significantly different between the groups. Significant correlations between (99m)Tc-DTPA clearance and blood lead concentrations (r=0.45; p<0.01) and between urinary albumin excretion and blood lead concentrations (r=0.71; p<0.001) were noted.

CONCLUSIONS

Use of renal scintigraphy in present study revealed measurable alterations of renal function under the conditions of low-level lead exposure and suggest that increased glomerular filtration may be an early indicator of kidney damage in subjects occupationally exposed to lead.

Authors+Show Affiliations

Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25735505

Citation

Wrońska-Nofer, Teresa, et al. "Scintigraphic Assessment of Renal Function in Steel Plant Workers Occupationally Exposed to Lead." Journal of Occupational Health, vol. 57, no. 2, 2015, pp. 91-9.
Wrońska-Nofer T, Pisarska A, Trzcinka-Ochocka M, et al. Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead. J Occup Health. 2015;57(2):91-9.
Wrońska-Nofer, T., Pisarska, A., Trzcinka-Ochocka, M., Hałatek, T., Stetkiewicz, J., Braziewicz, J., Nofer, J. R., & Wąsowicz, W. (2015). Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead. Journal of Occupational Health, 57(2), 91-9. https://doi.org/10.1539/joh.14-0115-OA
Wrońska-Nofer T, et al. Scintigraphic Assessment of Renal Function in Steel Plant Workers Occupationally Exposed to Lead. J Occup Health. 2015;57(2):91-9. PubMed PMID: 25735505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead. AU - Wrońska-Nofer,Teresa, AU - Pisarska,Anna, AU - Trzcinka-Ochocka,Małgorzata, AU - Hałatek,Tadeusz, AU - Stetkiewicz,Jan, AU - Braziewicz,Janusz, AU - Nofer,Jerzy-Roch, AU - Wąsowicz,Wojciech, Y1 - 2015/01/10/ PY - 2015/3/5/entrez PY - 2015/3/5/pubmed PY - 2016/1/16/medline SP - 91 EP - 9 JF - Journal of occupational health JO - J Occup Health VL - 57 IS - 2 N2 - OBJECTIVES: Occupational exposure to lead may produce kidney damage, but existing data on the dose range associated with nephrotoxicity are inconclusive. We here assessed renal function under conditions of low to moderate lead exposure using renal scintigraphy. METHODS: Fifty-three male foundrymen (exposed group) and fourty male office workers (control group) from a steel plant were included in the study. Glomerular and tubular renal function were assessed by means of (99m)Tc-DTPA and (99m)Tc-EC clearance, respectively. Urinary markers of glomerular dysfunction (albumin) and tubular damage (α1-microglobulin (α1M), β2-microglobulin (β2M), retinol-binding protein (RBP), N-acetyl-β-glucosaminidase (NAG) activity) were determined using latex beads tests or colorimetry. The lead concentration in blood was measured with atomic absorption spectrometry. RESULTS: The blood lead concentrations were 145.8 (121.3-175.3) and 39.3 (35.1-44.1) µg/l (geometric mean, 95(th) CI, p<0.001) in the exposed and control groups, respectively. Subjects exposed to lead presented with increased (99m)Tc-DTPA clearance (158.3 (148.4-168.8) vs. 135.9 (127.9-144.4) ml/min; p<0.01) and urinary albumin excretion (7.61 (6.28-9.22) vs. 4.78 (4.05-5.65) mg/g creatinine; p<0.001). (99m)Tc-EC clearance and excretion of α1M, β2M, RBP and NAG were not significantly different between the groups. Significant correlations between (99m)Tc-DTPA clearance and blood lead concentrations (r=0.45; p<0.01) and between urinary albumin excretion and blood lead concentrations (r=0.71; p<0.001) were noted. CONCLUSIONS: Use of renal scintigraphy in present study revealed measurable alterations of renal function under the conditions of low-level lead exposure and suggest that increased glomerular filtration may be an early indicator of kidney damage in subjects occupationally exposed to lead. SN - 1348-9585 UR - https://www.unboundmedicine.com/medline/citation/25735505/Scintigraphic_assessment_of_renal_function_in_steel_plant_workers_occupationally_exposed_to_lead_ L2 - https://dx.doi.org/10.1539/joh.14-0115-OA DB - PRIME DP - Unbound Medicine ER -