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Dietary legume consumption reduces risk of colorectal cancer: evidence from a meta-analysis of cohort studies.

Abstract

Previous epidemiological studies on the relation between dietary legume consumption and risk of colorectal cancer (CRC) remain controversial. We conducted a meta-analysis based on prospective cohort studies to investigate the association between dietary legume consumption and risk of CRC. Fourteen cohort studies were finally included, containing a total of 1,903,459 participants and 12,261 cases who contributed 11,628,960 person-years. We found that higher legume consumption was associated with a decreased risk of CRC (RR, relative risk = 0.91; 95% CI, confidence interval = 0.84-0.98). Subgroup analyses suggested that higher legume consumption was inversely associated with CRC risk in Asian (RR = 0.82; 95% CI = 0.74-0.91) and soybean intake was associated with a decreased risk of CRC (RR = 0.85; 95% CI = 0.73-0.99). Findings from our meta-analysis supported an association between higher intake of legume and a reduced risk of CRC. Further studies controlled for appropriate confounders are warranted to validate the associations.

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  • Authors+Show Affiliations

    ,

    State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment &Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

    ,

    State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment &Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, USA.

    ,

    State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment &Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

    State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment &Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

    Source

    Scientific reports 5: 2015 Mar 05 pg 8797

    MeSH

    Cohort Studies
    Colorectal Neoplasms
    Diet
    Fabaceae
    Humans
    Odds Ratio
    Publication Bias
    Risk

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25739376

    Citation

    Zhu, Beibei, et al. "Dietary Legume Consumption Reduces Risk of Colorectal Cancer: Evidence From a Meta-analysis of Cohort Studies." Scientific Reports, vol. 5, 2015, p. 8797.
    Zhu B, Sun Y, Qi L, et al. Dietary legume consumption reduces risk of colorectal cancer: evidence from a meta-analysis of cohort studies. Sci Rep. 2015;5:8797.
    Zhu, B., Sun, Y., Qi, L., Zhong, R., & Miao, X. (2015). Dietary legume consumption reduces risk of colorectal cancer: evidence from a meta-analysis of cohort studies. Scientific Reports, 5, p. 8797. doi:10.1038/srep08797.
    Zhu B, et al. Dietary Legume Consumption Reduces Risk of Colorectal Cancer: Evidence From a Meta-analysis of Cohort Studies. Sci Rep. 2015 Mar 5;5:8797. PubMed PMID: 25739376.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary legume consumption reduces risk of colorectal cancer: evidence from a meta-analysis of cohort studies. AU - Zhu,Beibei, AU - Sun,Yu, AU - Qi,Lu, AU - Zhong,Rong, AU - Miao,Xiaoping, Y1 - 2015/03/05/ PY - 2014/09/15/received PY - 2015/02/04/accepted PY - 2015/3/6/entrez PY - 2015/3/6/pubmed PY - 2015/12/15/medline SP - 8797 EP - 8797 JF - Scientific reports JO - Sci Rep VL - 5 N2 - Previous epidemiological studies on the relation between dietary legume consumption and risk of colorectal cancer (CRC) remain controversial. We conducted a meta-analysis based on prospective cohort studies to investigate the association between dietary legume consumption and risk of CRC. Fourteen cohort studies were finally included, containing a total of 1,903,459 participants and 12,261 cases who contributed 11,628,960 person-years. We found that higher legume consumption was associated with a decreased risk of CRC (RR, relative risk = 0.91; 95% CI, confidence interval = 0.84-0.98). Subgroup analyses suggested that higher legume consumption was inversely associated with CRC risk in Asian (RR = 0.82; 95% CI = 0.74-0.91) and soybean intake was associated with a decreased risk of CRC (RR = 0.85; 95% CI = 0.73-0.99). Findings from our meta-analysis supported an association between higher intake of legume and a reduced risk of CRC. Further studies controlled for appropriate confounders are warranted to validate the associations. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/25739376/full_citation L2 - http://dx.doi.org/10.1038/srep08797 DB - PRIME DP - Unbound Medicine ER -