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Yoga and meditation for menopausal symptoms in breast cancer survivors-A randomized controlled trial.
Cancer 2015; 121(13):2175-84C

Abstract

BACKGROUND

Breast cancer survivors have only very limited treatment options for menopausal symptoms. The objective of this trial was to evaluate the effects of a 12-week traditional Hatha yoga and meditation intervention on menopausal symptoms in breast cancer survivors.

METHODS

Patients were randomly assigned either to a 12-week yoga and meditation intervention or to usual care. The primary outcome measure was total menopausal symptoms (Menopause Rating Scale [MRS] total score). Secondary outcome measures included MRS subscales, quality of life (Functional Assessment of Cancer Therapy-Breast), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), depression, and anxiety (Hospital Anxiety and Depression Scale). Outcomes were assessed at week 12 and week 24 after randomization.

RESULTS

In total, 40 women (mean age ± standard deviation, 49.2 ± 5.9 years) were randomized to yoga (n = 19) or to usual care (n = 21). Women in the yoga group reported significantly lower total menopausal symptoms compared with the usual care group at week 12 (mean difference, -5.6; 95% confidence interval, -9.2 to -1.9; P = .004) and at week 24 (mean difference, -4.5; 95% confidence interval, -8.3 to -0.7; P = .023). At week 12, the yoga group reported less somatovegetative, psychological, and urogenital menopausal symptoms; less fatigue; and improved quality of life (all P < .05). At week 24, all effects persisted except for psychological menopausal symptoms. Short-term effects on menopausal symptoms remained significant when only women who were receiving antiestrogen medication (n = 36) were analyzed. Six minor adverse events occurred in each group.

CONCLUSIONS

Yoga combined with meditation can be considered a safe and effective complementary intervention for menopausal symptoms in breast cancer survivors. The effects seem to persist for at least 3 months.

Authors+Show Affiliations

Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany. Australian Research Center in Complementary and Integrative Medicine, Faculty of Health, University of Technology-Sydney, Sydney, Australia.Department of Gynecology, Certified Breast Center, Malteser Hospital St. Anna, Duisburg, Germany. Interdisclipinary Breast Cancer Center, Kliniken Essen-Mitte, Essen, Germany.Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany. Australian Research Center in Complementary and Integrative Medicine, Faculty of Health, University of Technology-Sydney, Sydney, Australia.Interdisclipinary Breast Cancer Center, Kliniken Essen-Mitte, Essen, Germany.Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

25739642

Citation

Cramer, Holger, et al. "Yoga and Meditation for Menopausal Symptoms in Breast Cancer survivors-A Randomized Controlled Trial." Cancer, vol. 121, no. 13, 2015, pp. 2175-84.
Cramer H, Rabsilber S, Lauche R, et al. Yoga and meditation for menopausal symptoms in breast cancer survivors-A randomized controlled trial. Cancer. 2015;121(13):2175-84.
Cramer, H., Rabsilber, S., Lauche, R., Kümmel, S., & Dobos, G. (2015). Yoga and meditation for menopausal symptoms in breast cancer survivors-A randomized controlled trial. Cancer, 121(13), pp. 2175-84. doi:10.1002/cncr.29330.
Cramer H, et al. Yoga and Meditation for Menopausal Symptoms in Breast Cancer survivors-A Randomized Controlled Trial. Cancer. 2015 Jul 1;121(13):2175-84. PubMed PMID: 25739642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Yoga and meditation for menopausal symptoms in breast cancer survivors-A randomized controlled trial. AU - Cramer,Holger, AU - Rabsilber,Sybille, AU - Lauche,Romy, AU - Kümmel,Sherko, AU - Dobos,Gustav, Y1 - 2015/03/04/ PY - 2014/09/02/received PY - 2014/11/25/revised PY - 2015/02/10/accepted PY - 2015/3/6/entrez PY - 2015/3/6/pubmed PY - 2016/9/1/medline KW - breast neoplasm KW - meditation KW - menopause KW - randomized controlled trial KW - yoga SP - 2175 EP - 84 JF - Cancer JO - Cancer VL - 121 IS - 13 N2 - BACKGROUND: Breast cancer survivors have only very limited treatment options for menopausal symptoms. The objective of this trial was to evaluate the effects of a 12-week traditional Hatha yoga and meditation intervention on menopausal symptoms in breast cancer survivors. METHODS: Patients were randomly assigned either to a 12-week yoga and meditation intervention or to usual care. The primary outcome measure was total menopausal symptoms (Menopause Rating Scale [MRS] total score). Secondary outcome measures included MRS subscales, quality of life (Functional Assessment of Cancer Therapy-Breast), fatigue (Functional Assessment of Chronic Illness Therapy-Fatigue), depression, and anxiety (Hospital Anxiety and Depression Scale). Outcomes were assessed at week 12 and week 24 after randomization. RESULTS: In total, 40 women (mean age ± standard deviation, 49.2 ± 5.9 years) were randomized to yoga (n = 19) or to usual care (n = 21). Women in the yoga group reported significantly lower total menopausal symptoms compared with the usual care group at week 12 (mean difference, -5.6; 95% confidence interval, -9.2 to -1.9; P = .004) and at week 24 (mean difference, -4.5; 95% confidence interval, -8.3 to -0.7; P = .023). At week 12, the yoga group reported less somatovegetative, psychological, and urogenital menopausal symptoms; less fatigue; and improved quality of life (all P < .05). At week 24, all effects persisted except for psychological menopausal symptoms. Short-term effects on menopausal symptoms remained significant when only women who were receiving antiestrogen medication (n = 36) were analyzed. Six minor adverse events occurred in each group. CONCLUSIONS: Yoga combined with meditation can be considered a safe and effective complementary intervention for menopausal symptoms in breast cancer survivors. The effects seem to persist for at least 3 months. SN - 1097-0142 UR - https://www.unboundmedicine.com/medline/citation/25739642/Yoga_and_meditation_for_menopausal_symptoms_in_breast_cancer_survivors_A_randomized_controlled_trial_ L2 - https://doi.org/10.1002/cncr.29330 DB - PRIME DP - Unbound Medicine ER -