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Intake of cruciferous vegetables is associated with reduced risk of ovarian cancer: a meta-analysis.

Abstract

BACKGROUND

Epidemiological studies on the association between cruciferous vegetable (CV) consumption and the risk of ovarian cancer have demonstrated inconsistent results. We conducted a meta-analysis on CV consumption and ovarian cancer risk.

METHODS

The relevant studies were identified by searching the Medline (Pubmed), Embase and Web of Science databases. The references of related articles and reviews up to October 2013 were also screened. The pooled relative risks (RRs) with 95% confidence intervals (CIs) for the highest versus the lowest CV consumption levels were calculated using a random-effects model. The heterogeneity and publication bias were also evaluated.

RESULTS

Eight studies (4 case-control studies and 4 cohort studies) were identified and included in this meta-analysis. When all studies were pooled together, there was a significantly inverse association between CV consumption and the risk of ovarian cancer (RR: 0.89; 95% CI: 0.81-0.99). No significant heterogeneity or publication bias was found.

CONCLUSIONS

The findings from this study suggest that the consumption of CVs may reduce the risk of ovarian cancer. Further investigations are needed to confirm the clinical effect of CVs on ovarian cancer.

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  • Authors+Show Affiliations

    ,

    Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China.

    ,

    Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China.

    ,

    Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China.

    Cancer Institute, Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, the Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou 310009, China. Email: zhengshuzuci@163.com.

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Brassicaceae
    Case-Control Studies
    Cohort Studies
    Diet
    Female
    Humans
    Middle Aged
    Ovarian Neoplasms
    Risk

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    25740748

    Citation

    Hu, Jiyi, et al. "Intake of Cruciferous Vegetables Is Associated With Reduced Risk of Ovarian Cancer: a Meta-analysis." Asia Pacific Journal of Clinical Nutrition, vol. 24, no. 1, 2015, pp. 101-9.
    Hu J, Hu Y, Hu Y, et al. Intake of cruciferous vegetables is associated with reduced risk of ovarian cancer: a meta-analysis. Asia Pac J Clin Nutr. 2015;24(1):101-9.
    Hu, J., Hu, Y., Hu, Y., & Zheng, S. (2015). Intake of cruciferous vegetables is associated with reduced risk of ovarian cancer: a meta-analysis. Asia Pacific Journal of Clinical Nutrition, 24(1), pp. 101-9. doi:10.6133/apjcn.2015.24.1.22.
    Hu J, et al. Intake of Cruciferous Vegetables Is Associated With Reduced Risk of Ovarian Cancer: a Meta-analysis. Asia Pac J Clin Nutr. 2015;24(1):101-9. PubMed PMID: 25740748.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intake of cruciferous vegetables is associated with reduced risk of ovarian cancer: a meta-analysis. AU - Hu,Jiyi, AU - Hu,Yiwang, AU - Hu,Yeting, AU - Zheng,Shu, PY - 2015/3/6/entrez PY - 2015/3/6/pubmed PY - 2015/4/25/medline SP - 101 EP - 9 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 24 IS - 1 N2 - BACKGROUND: Epidemiological studies on the association between cruciferous vegetable (CV) consumption and the risk of ovarian cancer have demonstrated inconsistent results. We conducted a meta-analysis on CV consumption and ovarian cancer risk. METHODS: The relevant studies were identified by searching the Medline (Pubmed), Embase and Web of Science databases. The references of related articles and reviews up to October 2013 were also screened. The pooled relative risks (RRs) with 95% confidence intervals (CIs) for the highest versus the lowest CV consumption levels were calculated using a random-effects model. The heterogeneity and publication bias were also evaluated. RESULTS: Eight studies (4 case-control studies and 4 cohort studies) were identified and included in this meta-analysis. When all studies were pooled together, there was a significantly inverse association between CV consumption and the risk of ovarian cancer (RR: 0.89; 95% CI: 0.81-0.99). No significant heterogeneity or publication bias was found. CONCLUSIONS: The findings from this study suggest that the consumption of CVs may reduce the risk of ovarian cancer. Further investigations are needed to confirm the clinical effect of CVs on ovarian cancer. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/25740748/full_citation L2 - http://apjcn.nhri.org.tw/server/APJCN/24/1/101.pdf DB - PRIME DP - Unbound Medicine ER -