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Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population.
Eur J Endocrinol. 2015 Jun; 172(6):657-67.EJ

Abstract

OBJECTIVE

Selenium is present in the active site of proteins important for thyroid hormone synthesis and metabolism. The objective of this study is to investigate the effect of selenium supplementation in different doses on thyroid function, under conditions of suboptimal dietary selenium intake.

DESIGN

The Danish PREvention of Cancer by Intervention with SElenium pilot study (DK-PRECISE) is a randomized, double-blinded, placebo-controlled trial. A total of 491 males and females aged 60-74 years were randomized to 100 μg (n=124), 200 μg (n=122), or 300 μg (n=119) selenium-enriched yeast or matching yeast-based placebo tablets (n=126). A total of 361 participants, equally distributed across treatment groups, completed the 5-year intervention period.

METHODS

Plasma samples were analyzed for selenium and serum samples for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) at baseline, and after 6 months, and 5 years of supplementation.

RESULTS

Plasma selenium concentrations increased significantly and dose-dependently in treatment groups receiving selenium (P<0.001). Serum TSH and FT4 concentrations decreased significantly and dose-dependently by 0.066 mIU/l (P=0.010) and 0.11 pmol/l (P=0.015), respectively, per 100 μg/day increase, with insignificant differences between 6 months and 5 years. No significant effects were found for FT3 and FT3:FT4 ratio.

CONCLUSIONS

In euthyroid subjects, selenium supplementation minutely and dose-dependently affects thyroid function, when compared with placebo, by decreasing serum TSH and FT4 concentrations. Based on these findings, selenium supplementation is not warranted under conditions of marginal selenium deficiency. However, a role for selenium supplementation in the treatment of autoimmune thyroid diseases is still unresolved.

Authors+Show Affiliations

Department of Endocrinology and MetabolismOdense University Hospital, Kloevervaenget 10, 6. Sal, DK-5000 Odense C, DenmarkDepartment of OncologyOdense University Hospital, Odense, DenmarkDepartment of EpidemiologyBiostatistics and Biodemography, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark kristian.winther@rsyd.dk.Department of Endocrinology and MetabolismOdense University Hospital, Kloevervaenget 10, 6. Sal, DK-5000 Odense C, DenmarkDepartment of OncologyOdense University Hospital, Odense, DenmarkDepartment of EpidemiologyBiostatistics and Biodemography, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.Department of Endocrinology and MetabolismOdense University Hospital, Kloevervaenget 10, 6. Sal, DK-5000 Odense C, DenmarkDepartment of OncologyOdense University Hospital, Odense, DenmarkDepartment of EpidemiologyBiostatistics and Biodemography, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.Department of Endocrinology and MetabolismOdense University Hospital, Kloevervaenget 10, 6. Sal, DK-5000 Odense C, DenmarkDepartment of OncologyOdense University Hospital, Odense, DenmarkDepartment of EpidemiologyBiostatistics and Biodemography, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.Department of Endocrinology and MetabolismOdense University Hospital, Kloevervaenget 10, 6. Sal, DK-5000 Odense C, DenmarkDepartment of OncologyOdense University Hospital, Odense, DenmarkDepartment of EpidemiologyBiostatistics and Biodemography, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.Department of Endocrinology and MetabolismOdense University Hospital, Kloevervaenget 10, 6. Sal, DK-5000 Odense C, DenmarkDepartment of OncologyOdense University Hospital, Odense, DenmarkDepartment of EpidemiologyBiostatistics and Biodemography, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.Department of Endocrinology and MetabolismOdense University Hospital, Kloevervaenget 10, 6. Sal, DK-5000 Odense C, DenmarkDepartment of OncologyOdense University Hospital, Odense, DenmarkDepartment of EpidemiologyBiostatistics and Biodemography, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Biochemistry and PharmacologyOdense University Hospital, Odense, Denmark.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25740851

Citation

Winther, Kristian Hillert, et al. "Does Selenium Supplementation Affect Thyroid Function? Results From a Randomized, Controlled, Double-blinded Trial in a Danish Population." European Journal of Endocrinology, vol. 172, no. 6, 2015, pp. 657-67.
Winther KH, Bonnema SJ, Cold F, et al. Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population. Eur J Endocrinol. 2015;172(6):657-67.
Winther, K. H., Bonnema, S. J., Cold, F., Debrabant, B., Nybo, M., Cold, S., & Hegedüs, L. (2015). Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population. European Journal of Endocrinology, 172(6), 657-67. https://doi.org/10.1530/EJE-15-0069
Winther KH, et al. Does Selenium Supplementation Affect Thyroid Function? Results From a Randomized, Controlled, Double-blinded Trial in a Danish Population. Eur J Endocrinol. 2015;172(6):657-67. PubMed PMID: 25740851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population. AU - Winther,Kristian Hillert, AU - Bonnema,Steen Joop, AU - Cold,Frederik, AU - Debrabant,Birgit, AU - Nybo,Mads, AU - Cold,Søren, AU - Hegedüs,Laszlo, Y1 - 2015/03/04/ PY - 2015/01/19/received PY - 2015/03/04/accepted PY - 2015/3/6/entrez PY - 2015/3/6/pubmed PY - 2015/7/7/medline SP - 657 EP - 67 JF - European journal of endocrinology JO - Eur. J. Endocrinol. VL - 172 IS - 6 N2 - OBJECTIVE: Selenium is present in the active site of proteins important for thyroid hormone synthesis and metabolism. The objective of this study is to investigate the effect of selenium supplementation in different doses on thyroid function, under conditions of suboptimal dietary selenium intake. DESIGN: The Danish PREvention of Cancer by Intervention with SElenium pilot study (DK-PRECISE) is a randomized, double-blinded, placebo-controlled trial. A total of 491 males and females aged 60-74 years were randomized to 100 μg (n=124), 200 μg (n=122), or 300 μg (n=119) selenium-enriched yeast or matching yeast-based placebo tablets (n=126). A total of 361 participants, equally distributed across treatment groups, completed the 5-year intervention period. METHODS: Plasma samples were analyzed for selenium and serum samples for TSH, free triiodothyronine (FT3), and free thyroxine (FT4) at baseline, and after 6 months, and 5 years of supplementation. RESULTS: Plasma selenium concentrations increased significantly and dose-dependently in treatment groups receiving selenium (P<0.001). Serum TSH and FT4 concentrations decreased significantly and dose-dependently by 0.066 mIU/l (P=0.010) and 0.11 pmol/l (P=0.015), respectively, per 100 μg/day increase, with insignificant differences between 6 months and 5 years. No significant effects were found for FT3 and FT3:FT4 ratio. CONCLUSIONS: In euthyroid subjects, selenium supplementation minutely and dose-dependently affects thyroid function, when compared with placebo, by decreasing serum TSH and FT4 concentrations. Based on these findings, selenium supplementation is not warranted under conditions of marginal selenium deficiency. However, a role for selenium supplementation in the treatment of autoimmune thyroid diseases is still unresolved. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/25740851/Does_selenium_supplementation_affect_thyroid_function_Results_from_a_randomized_controlled_double_blinded_trial_in_a_Danish_population_ L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-15-0069 DB - PRIME DP - Unbound Medicine ER -