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Antagonism by glucocorticoids and exercise on expression of glutamine synthetase in skeletal muscle.
FASEB J. 1989 Dec; 3(14):2623-8.FJ

Abstract

Chronic glucocorticoid treatment results in skeletal muscle wasting. However, if the contractile activity of muscle is increased, this effect is abated. Because the gene encoding glutamine synthetase is known to be glucocorticoid inducible, it represents an appropriate model for testing whether glucocorticoids and endurance training can exert antagonistic effects on the expression of specific genes in muscle tissue. Our data confirm that administration of hydrocortisone 21-acetate to rats produces 2.4- and 5.9-fold increases in plantaris muscle glutamine synthetase enzyme activity and mRNA, respectively. Moreover, subjecting rats to a 12- to 16-wk exercise program diminishes the basal levels of these indices of glutamine synthetase expression to approximately 60% of the values observed in sedentary controls. Endurance training produces a similar effect on plantaris muscle glutamine synthetase expression in glucocorticoid-treated animals. These data demonstrate that the therapeutic effects of exercise in counteracting muscle atrophy are associated with attenuation of expression of a glucocorticoid-inducible gene in skeletal muscle.

Authors+Show Affiliations

Department of Physical Education, University of Illinois, Chicago 60680.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

2574120

Citation

Falduto, M T., et al. "Antagonism By Glucocorticoids and Exercise On Expression of Glutamine Synthetase in Skeletal Muscle." FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 3, no. 14, 1989, pp. 2623-8.
Falduto MT, Hickson RC, Young AP. Antagonism by glucocorticoids and exercise on expression of glutamine synthetase in skeletal muscle. FASEB J. 1989;3(14):2623-8.
Falduto, M. T., Hickson, R. C., & Young, A. P. (1989). Antagonism by glucocorticoids and exercise on expression of glutamine synthetase in skeletal muscle. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 3(14), 2623-8.
Falduto MT, Hickson RC, Young AP. Antagonism By Glucocorticoids and Exercise On Expression of Glutamine Synthetase in Skeletal Muscle. FASEB J. 1989;3(14):2623-8. PubMed PMID: 2574120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antagonism by glucocorticoids and exercise on expression of glutamine synthetase in skeletal muscle. AU - Falduto,M T, AU - Hickson,R C, AU - Young,A P, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 2623 EP - 8 JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology JO - FASEB J VL - 3 IS - 14 N2 - Chronic glucocorticoid treatment results in skeletal muscle wasting. However, if the contractile activity of muscle is increased, this effect is abated. Because the gene encoding glutamine synthetase is known to be glucocorticoid inducible, it represents an appropriate model for testing whether glucocorticoids and endurance training can exert antagonistic effects on the expression of specific genes in muscle tissue. Our data confirm that administration of hydrocortisone 21-acetate to rats produces 2.4- and 5.9-fold increases in plantaris muscle glutamine synthetase enzyme activity and mRNA, respectively. Moreover, subjecting rats to a 12- to 16-wk exercise program diminishes the basal levels of these indices of glutamine synthetase expression to approximately 60% of the values observed in sedentary controls. Endurance training produces a similar effect on plantaris muscle glutamine synthetase expression in glucocorticoid-treated animals. These data demonstrate that the therapeutic effects of exercise in counteracting muscle atrophy are associated with attenuation of expression of a glucocorticoid-inducible gene in skeletal muscle. SN - 0892-6638 UR - https://www.unboundmedicine.com/medline/citation/2574120/Antagonism_by_glucocorticoids_and_exercise_on_expression_of_glutamine_synthetase_in_skeletal_muscle_ L2 - https://doi.org/10.1096/fasebj.3.14.2574120 DB - PRIME DP - Unbound Medicine ER -