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Effects of anticholinergic agents on patients with tardive dyskinesia and concomitant drug-induced parkinsonism.
J Clin Psychopharmacol. 1989 Dec; 9(6):407-11.JC

Abstract

Twenty-five percent of 80 consecutive patients who met research criteria for persistent tardive dyskinesia (TD) were found to have an energy peak in the parkinsonian tremor band (3-6 Hz) of the frequency spectrum of their machine-measured resting hand movements in addition to the abnormalities consistent with TD (increased energy in the 0.5-3 Hz frequency spectrum). Twelve of these patients were studied again in double-blind fashion 2 hours after receiving a placebo and again 2 hours after a single 4 mg dose of trihexyphenidyl hydrochloride (HCl). Compared with the placebo condition, the trihexyphenidyl HCl markedly diminished the measured energy in the 4 Hz band and had no effect or slightly decreased the energy at all other points on the frequency spectrum. Simultaneous Abnormal Involuntary Movement Scale ratings revealed no change in the dyskinetic movements between the conditions; there was a significant subjective improvement reported by the patients following the trihexyphenidyl HCl administration. These observations indicate that electromechanical devices identify a subpopulation of TD patients who may acutely benefit from anticholinergic treatment.

Authors+Show Affiliations

Brentwood Movement Disorders Laboratory, UCLA School of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

2574192

Citation

Wirshing, W C., et al. "Effects of Anticholinergic Agents On Patients With Tardive Dyskinesia and Concomitant Drug-induced Parkinsonism." Journal of Clinical Psychopharmacology, vol. 9, no. 6, 1989, pp. 407-11.
Wirshing WC, Freidenberg DL, Cummings JL, et al. Effects of anticholinergic agents on patients with tardive dyskinesia and concomitant drug-induced parkinsonism. J Clin Psychopharmacol. 1989;9(6):407-11.
Wirshing, W. C., Freidenberg, D. L., Cummings, J. L., & Bartzokis, G. (1989). Effects of anticholinergic agents on patients with tardive dyskinesia and concomitant drug-induced parkinsonism. Journal of Clinical Psychopharmacology, 9(6), 407-11.
Wirshing WC, et al. Effects of Anticholinergic Agents On Patients With Tardive Dyskinesia and Concomitant Drug-induced Parkinsonism. J Clin Psychopharmacol. 1989;9(6):407-11. PubMed PMID: 2574192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of anticholinergic agents on patients with tardive dyskinesia and concomitant drug-induced parkinsonism. AU - Wirshing,W C, AU - Freidenberg,D L, AU - Cummings,J L, AU - Bartzokis,G, PY - 1989/12/1/pubmed PY - 1989/12/1/medline PY - 1989/12/1/entrez SP - 407 EP - 11 JF - Journal of clinical psychopharmacology JO - J Clin Psychopharmacol VL - 9 IS - 6 N2 - Twenty-five percent of 80 consecutive patients who met research criteria for persistent tardive dyskinesia (TD) were found to have an energy peak in the parkinsonian tremor band (3-6 Hz) of the frequency spectrum of their machine-measured resting hand movements in addition to the abnormalities consistent with TD (increased energy in the 0.5-3 Hz frequency spectrum). Twelve of these patients were studied again in double-blind fashion 2 hours after receiving a placebo and again 2 hours after a single 4 mg dose of trihexyphenidyl hydrochloride (HCl). Compared with the placebo condition, the trihexyphenidyl HCl markedly diminished the measured energy in the 4 Hz band and had no effect or slightly decreased the energy at all other points on the frequency spectrum. Simultaneous Abnormal Involuntary Movement Scale ratings revealed no change in the dyskinetic movements between the conditions; there was a significant subjective improvement reported by the patients following the trihexyphenidyl HCl administration. These observations indicate that electromechanical devices identify a subpopulation of TD patients who may acutely benefit from anticholinergic treatment. SN - 0271-0749 UR - https://www.unboundmedicine.com/medline/citation/2574192/Effects_of_anticholinergic_agents_on_patients_with_tardive_dyskinesia_and_concomitant_drug_induced_parkinsonism_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2574192.ui DB - PRIME DP - Unbound Medicine ER -