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Hypertension in patients with cancer.

Abstract

There is a known association between chemotherapy and radiotherapy for treatment of cancer patients and development or worsening of hypertension. The aim of this article is to review this association. A literature search was conducted for articles reporting this association on the databases PubMed, SciELO and LILACS between 1993 and 2013. There was a high coprevalence of hypertension and cancer, since both diseases share the same risk factors, such as sedentary lifestyle, obesity, smoking, unhealthy diet and alcohol abuse. The use of chemotherapy and adjuvant drugs effective in the treatment of cancer increased the survival rate of these patients and, consequently, increased the incidence of hypertension. We described the association between the use of angiogenesis inhibitors (bevacizumab, sorafenib and sunitinib), corticosteroids, erythropoietin and non-steroidal anti-inflammatory drugs with the development of hypertension. We also described the relationship between hypertension and carotid baroreceptor injury secondary to cervical radiotherapy. Morbidity and mortality increased in patients with cancer and hypertension without proper antihypertensive treatment. We concluded that there is need for early diagnosis, effective monitoring and treatment strategies for hypertension in cancer patients in order to reduce cardiovascular morbidity and mortality.

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  • Authors+Show Affiliations

    ,

    Curso de Pós-Graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, Brazil.

    ,

    Curso de Pós-Graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, Brazil.

    ,

    Curso de Pós-Graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, Brazil.

    Curso de Pós-Graduação em Ciências Cardiovasculares, Universidade Federal Fluminense, Niterói, RJ, Brazil.

    Source

    Arquivos brasileiros de cardiologia 104:3 2015 Mar pg 246-52

    MeSH

    Antihypertensive Agents
    Antineoplastic Agents
    Chemotherapy, Adjuvant
    Humans
    Hypertension
    Neoplasms
    Radiotherapy
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng por

    PubMed ID

    25742420

    Citation

    Souza, Vinicius Barbosa de, et al. "Hypertension in Patients With Cancer." Arquivos Brasileiros De Cardiologia, vol. 104, no. 3, 2015, pp. 246-52.
    Souza VB, Silva EN, Ribeiro ML, et al. Hypertension in patients with cancer. Arq Bras Cardiol. 2015;104(3):246-52.
    Souza, V. B., Silva, E. N., Ribeiro, M. L., & Martins, W. d. e. . A. (2015). Hypertension in patients with cancer. Arquivos Brasileiros De Cardiologia, 104(3), pp. 246-52. doi:10.5935/abc.20150011.
    Souza VB, et al. Hypertension in Patients With Cancer. Arq Bras Cardiol. 2015;104(3):246-52. PubMed PMID: 25742420.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hypertension in patients with cancer. AU - Souza,Vinicius Barbosa de, AU - Silva,Eduardo Nani, AU - Ribeiro,Mario Luiz, AU - Martins,Wolney de Andrade, Y1 - 2015/02/27/ PY - 2014/06/06/received PY - 2014/07/09/accepted PY - 2015/3/6/entrez PY - 2015/3/6/pubmed PY - 2015/9/24/medline SP - 246 EP - 52 JF - Arquivos brasileiros de cardiologia JO - Arq. Bras. Cardiol. VL - 104 IS - 3 N2 - There is a known association between chemotherapy and radiotherapy for treatment of cancer patients and development or worsening of hypertension. The aim of this article is to review this association. A literature search was conducted for articles reporting this association on the databases PubMed, SciELO and LILACS between 1993 and 2013. There was a high coprevalence of hypertension and cancer, since both diseases share the same risk factors, such as sedentary lifestyle, obesity, smoking, unhealthy diet and alcohol abuse. The use of chemotherapy and adjuvant drugs effective in the treatment of cancer increased the survival rate of these patients and, consequently, increased the incidence of hypertension. We described the association between the use of angiogenesis inhibitors (bevacizumab, sorafenib and sunitinib), corticosteroids, erythropoietin and non-steroidal anti-inflammatory drugs with the development of hypertension. We also described the relationship between hypertension and carotid baroreceptor injury secondary to cervical radiotherapy. Morbidity and mortality increased in patients with cancer and hypertension without proper antihypertensive treatment. We concluded that there is need for early diagnosis, effective monitoring and treatment strategies for hypertension in cancer patients in order to reduce cardiovascular morbidity and mortality. SN - 1678-4170 UR - https://www.unboundmedicine.com/medline/citation/25742420/full_citation L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2015005050011&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -