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Serological effects of Edmonston-Zagreb, Schwarz, and AIK-C measles vaccine strains given at ages 4-5 or 8-10 months.
Lancet. 1989 Dec 09; 2(8676):1357-60.Lct

Abstract

To examine the value of vaccinating children against measles at age 4-5 months three groups of children in Togo were randomly assigned to receive high-dose Edmonston-Zagreb, high-dose Schwarz, or AIK-C vaccines at that age. Two other groups were vaccinated at age 8-10 months, with either the standard Schwarz vaccine or the same batch of AIK-C as for early immunisation. For the 55% of children who were seronegative before vaccination at age 4-5 months seroconversion rates were 96% with the AIK-C, 94% with the Edmonston-Zagreb, and 50% with the high-dose Schwarz. The immune response rates for children who were seropositive before vaccination were estimated to be around 50% with the high-dose Edmonston-Zagreb and AIK-C strains and 10% with the Schwarz strain. Seroconversion rates for vaccination at 8-10 months were 87% for the AIK-C and 68% for the Schwarz strains. Thus vaccination with the high-dose Edmonston-Zagreb or the AIK-C strain at 4-5 months was as good as vaccination with the AIK-C strain at 8-10 months and better than vaccination with the standard dose Schwarz strain at 8-10 months. These findings require confirmation by further investigations, particularly epidemiological studies, but they already provide evidence that the administration of AIK-C and high-dose Edmonston-Zagreb strains at 4-5 months is at least as effective as vaccination with the standard strains at 8-10 months.

Authors+Show Affiliations

CHU, Lomé, Togo.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2574304

Citation

Tidjani, O, et al. "Serological Effects of Edmonston-Zagreb, Schwarz, and AIK-C Measles Vaccine Strains Given at Ages 4-5 or 8-10 Months." Lancet (London, England), vol. 2, no. 8676, 1989, pp. 1357-60.
Tidjani O, Grunitsky B, Guérin N, et al. Serological effects of Edmonston-Zagreb, Schwarz, and AIK-C measles vaccine strains given at ages 4-5 or 8-10 months. Lancet. 1989;2(8676):1357-60.
Tidjani, O., Grunitsky, B., Guérin, N., Lévy-Bruhl, D., Lecam, N., Xuereff, C., & Tatagan, K. (1989). Serological effects of Edmonston-Zagreb, Schwarz, and AIK-C measles vaccine strains given at ages 4-5 or 8-10 months. Lancet (London, England), 2(8676), 1357-60.
Tidjani O, et al. Serological Effects of Edmonston-Zagreb, Schwarz, and AIK-C Measles Vaccine Strains Given at Ages 4-5 or 8-10 Months. Lancet. 1989 Dec 9;2(8676):1357-60. PubMed PMID: 2574304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serological effects of Edmonston-Zagreb, Schwarz, and AIK-C measles vaccine strains given at ages 4-5 or 8-10 months. AU - Tidjani,O, AU - Grunitsky,B, AU - Guérin,N, AU - Lévy-Bruhl,D, AU - Lecam,N, AU - Xuereff,C, AU - Tatagan,K, PY - 1989/12/9/pubmed PY - 1989/12/9/medline PY - 1989/12/9/entrez SP - 1357 EP - 60 JF - Lancet (London, England) JO - Lancet VL - 2 IS - 8676 N2 - To examine the value of vaccinating children against measles at age 4-5 months three groups of children in Togo were randomly assigned to receive high-dose Edmonston-Zagreb, high-dose Schwarz, or AIK-C vaccines at that age. Two other groups were vaccinated at age 8-10 months, with either the standard Schwarz vaccine or the same batch of AIK-C as for early immunisation. For the 55% of children who were seronegative before vaccination at age 4-5 months seroconversion rates were 96% with the AIK-C, 94% with the Edmonston-Zagreb, and 50% with the high-dose Schwarz. The immune response rates for children who were seropositive before vaccination were estimated to be around 50% with the high-dose Edmonston-Zagreb and AIK-C strains and 10% with the Schwarz strain. Seroconversion rates for vaccination at 8-10 months were 87% for the AIK-C and 68% for the Schwarz strains. Thus vaccination with the high-dose Edmonston-Zagreb or the AIK-C strain at 4-5 months was as good as vaccination with the AIK-C strain at 8-10 months and better than vaccination with the standard dose Schwarz strain at 8-10 months. These findings require confirmation by further investigations, particularly epidemiological studies, but they already provide evidence that the administration of AIK-C and high-dose Edmonston-Zagreb strains at 4-5 months is at least as effective as vaccination with the standard strains at 8-10 months. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2574304/Serological_effects_of_Edmonston_Zagreb_Schwarz_and_AIK_C_measles_vaccine_strains_given_at_ages_4_5_or_8_10_months_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0140-6736(89)91967-3 DB - PRIME DP - Unbound Medicine ER -