Tags

Type your tag names separated by a space and hit enter

Sural-sparing is seen in axonal as well as demyelinating forms of Guillain-Barré syndrome.
Clin Neurophysiol. 2015 Dec; 126(12):2376-80.CN

Abstract

OBJECTIVE

The "sural-sparing pattern" of Guillain-Barré syndrome (GBS) is believed to reflect demyelinating pathology. We asked if it is present in non-demyelinating GBS-subtypes, namely acute motor axonal neuropathy (AMAN), acute motor-sensory axonal neuropathy (AMSAN) and Miller Fisher syndrome (MFS), in addition to acute inflammatory demyelinating polyneuropathy (AIDP).

METHODS

We studied the occurrence of sural-sparing pattern in clinically defined GBS and MFS patients. Using serial electrodiagnostic studies, GBS patients were divided into AIDP, according to appearance of demyelination-remyelination and AMAN/AMSAN, if there were signs of reversible conduction failure or Wallerian-like degeneration. Equivocal cases were left unclassified. We defined sural-sparing as a greater decrease in median and or ulnar sensory nerve action potential than that of the sural, compared to age and height-matched normal controls.

RESULTS

Twelve of 30 GBS and 7 of 20 MFS patients had sural-sparing. This pattern was seen in 4 of 8 AIDP, 5 of 13 AMAN/AMSAN and 3 of 9 unclassified cases. Sequential studies uncovered sural-sparing, initially covert, in additional 1 MFS, 1 unclassified, 1 AIDP and 1 AMAN/AMSAN patient.

CONCLUSIONS

Sural-sparing occurs in axonal and demyelinating GBS subtypes.

SIGNIFICANCE

The sural-sparing pattern reflects a pathological process common to axonal and demyelinating GBS-subtypes alike.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Umapathi T
Department of Neurology, National Neuroscience Institute, Singapore. Electronic address: umapathi@nni.com.sg.
Li Z
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Verma K
Department of Neurology, National Neuroscience Institute, Singapore.
Yuki N
Departments of Medicine and Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

MeSH

AdolescentAdultAgedAxonsDemyelinating DiseasesFemaleGuillain-Barre SyndromeHumansMaleMiddle AgedMiller Fisher SyndromeSural NerveYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25743269

Citation

Umapathi, Thirugnanam, et al. "Sural-sparing Is Seen in Axonal as Well as Demyelinating Forms of Guillain-Barré Syndrome." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 126, no. 12, 2015, pp. 2376-80.
Umapathi T, Li Z, Verma K, et al. Sural-sparing is seen in axonal as well as demyelinating forms of Guillain-Barré syndrome. Clin Neurophysiol. 2015;126(12):2376-80.
Umapathi, T., Li, Z., Verma, K., & Yuki, N. (2015). Sural-sparing is seen in axonal as well as demyelinating forms of Guillain-Barré syndrome. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 126(12), 2376-80. https://doi.org/10.1016/j.clinph.2015.01.016
Umapathi T, et al. Sural-sparing Is Seen in Axonal as Well as Demyelinating Forms of Guillain-Barré Syndrome. Clin Neurophysiol. 2015;126(12):2376-80. PubMed PMID: 25743269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sural-sparing is seen in axonal as well as demyelinating forms of Guillain-Barré syndrome. AU - Umapathi,Thirugnanam, AU - Li,Zongbin, AU - Verma,Kamal, AU - Yuki,Nobuhiro, Y1 - 2015/02/09/ PY - 2014/11/11/received PY - 2015/01/11/revised PY - 2015/01/28/accepted PY - 2015/3/7/entrez PY - 2015/3/7/pubmed PY - 2016/3/15/medline KW - Electrodiagnosis KW - Guillain–Barré syndrome KW - Sural-sparing SP - 2376 EP - 80 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 126 IS - 12 N2 - OBJECTIVE: The "sural-sparing pattern" of Guillain-Barré syndrome (GBS) is believed to reflect demyelinating pathology. We asked if it is present in non-demyelinating GBS-subtypes, namely acute motor axonal neuropathy (AMAN), acute motor-sensory axonal neuropathy (AMSAN) and Miller Fisher syndrome (MFS), in addition to acute inflammatory demyelinating polyneuropathy (AIDP). METHODS: We studied the occurrence of sural-sparing pattern in clinically defined GBS and MFS patients. Using serial electrodiagnostic studies, GBS patients were divided into AIDP, according to appearance of demyelination-remyelination and AMAN/AMSAN, if there were signs of reversible conduction failure or Wallerian-like degeneration. Equivocal cases were left unclassified. We defined sural-sparing as a greater decrease in median and or ulnar sensory nerve action potential than that of the sural, compared to age and height-matched normal controls. RESULTS: Twelve of 30 GBS and 7 of 20 MFS patients had sural-sparing. This pattern was seen in 4 of 8 AIDP, 5 of 13 AMAN/AMSAN and 3 of 9 unclassified cases. Sequential studies uncovered sural-sparing, initially covert, in additional 1 MFS, 1 unclassified, 1 AIDP and 1 AMAN/AMSAN patient. CONCLUSIONS: Sural-sparing occurs in axonal and demyelinating GBS subtypes. SIGNIFICANCE: The sural-sparing pattern reflects a pathological process common to axonal and demyelinating GBS-subtypes alike. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/25743269/Sural_sparing_is_seen_in_axonal_as_well_as_demyelinating_forms_of_Guillain_Barré_syndrome_ DB - PRIME DP - Unbound Medicine ER -