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A randomized intervention trial of 24-wk dairy consumption on waist circumference, blood pressure, and fasting blood sugar and lipids in Japanese men with metabolic syndrome.
J Nutr Sci Vitaminol (Tokyo). 2014; 60(5):305-12.JN

Abstract

Dairy foods are postulated to have beneficial effects on blood pressure, body fat, serum lipids, and the incidence of type 2 diabetes. To evaluate the effects of the consumption of milk and dairy products, we performed a randomized dietary intervention trial for 24 wk in Japanese men, aged 20 to 60 y, with 2 or more components of the metabolic syndrome (

CLINICAL TRIAL REGISTRATION

UMIN000006353). Subjects were randomized to a control group (n=98) that received dietary intervention focused on weight control supervised by registered dietitians, and a dairy-consumption group (n=102) that received both dietary intervention and regular home dairy delivery of 400 g/d for 24 wk. Co-primary endpoints included waist circumference, blood pressure, fasting blood sugar (FBS), and serum lipids. The dietary intervention decreased energy intake from 2,150 to 1,850 kcal/d in both groups (p<0.01). Mean rates of compliance with the dairy-consumption intervention were over 90%, resulting in increased calcium intake in the dairy-consumption group from 329 to 667 mg/d (p<0.01). Co-primary endpoints improved in both groups, but the degree of improvement was smaller in the dairy-consumption group (one-sided p=0.99). Subgroup analyses specified in the study protocol identified weight and leisure-time physical activity (LTPA) as significant effect modifiers. Differences in changes in systolic blood pressure compared with the control group were 28.0 mmHg (95% CI, 214.0 to 21.9, interaction; p<0.01) in the normal weight group and 25.8 mmHg (211.4 to 20.2, interaction; p=0.02) in the moderate-to-high LTPA group, indicating lower systolic blood pressure in the dairy-consumption group among participants in these subgroups. In conclusion, although effects on the co-primary endpoints of dairy consumption were not shown, dairy consumption lowered systolic blood pressure in the subgroups with normal weight and moderate-to-high LTPA and lowered FBS in the subgroup with normal weight.

Authors+Show Affiliations

Department of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25744418

Citation

Tanaka, Shiro, et al. "A Randomized Intervention Trial of 24-wk Dairy Consumption On Waist Circumference, Blood Pressure, and Fasting Blood Sugar and Lipids in Japanese Men With Metabolic Syndrome." Journal of Nutritional Science and Vitaminology, vol. 60, no. 5, 2014, pp. 305-12.
Tanaka S, Uenishi K, Ishida H, et al. A randomized intervention trial of 24-wk dairy consumption on waist circumference, blood pressure, and fasting blood sugar and lipids in Japanese men with metabolic syndrome. J Nutr Sci Vitaminol (Tokyo). 2014;60(5):305-12.
Tanaka, S., Uenishi, K., Ishida, H., Takami, Y., Hosoi, T., Kadowaki, T., Orimo, H., & Ohashi, Y. (2014). A randomized intervention trial of 24-wk dairy consumption on waist circumference, blood pressure, and fasting blood sugar and lipids in Japanese men with metabolic syndrome. Journal of Nutritional Science and Vitaminology, 60(5), 305-12. https://doi.org/10.3177/jnsv.60.305
Tanaka S, et al. A Randomized Intervention Trial of 24-wk Dairy Consumption On Waist Circumference, Blood Pressure, and Fasting Blood Sugar and Lipids in Japanese Men With Metabolic Syndrome. J Nutr Sci Vitaminol (Tokyo). 2014;60(5):305-12. PubMed PMID: 25744418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized intervention trial of 24-wk dairy consumption on waist circumference, blood pressure, and fasting blood sugar and lipids in Japanese men with metabolic syndrome. AU - Tanaka,Shiro, AU - Uenishi,Kazuhiro, AU - Ishida,Hiromi, AU - Takami,Yasuhiro, AU - Hosoi,Takayuki, AU - Kadowaki,Takashi, AU - Orimo,Hajime, AU - Ohashi,Yasuo, PY - 2015/3/7/entrez PY - 2014/1/1/pubmed PY - 2015/10/23/medline SP - 305 EP - 12 JF - Journal of nutritional science and vitaminology JO - J Nutr Sci Vitaminol (Tokyo) VL - 60 IS - 5 N2 - UNLABELLED: Dairy foods are postulated to have beneficial effects on blood pressure, body fat, serum lipids, and the incidence of type 2 diabetes. To evaluate the effects of the consumption of milk and dairy products, we performed a randomized dietary intervention trial for 24 wk in Japanese men, aged 20 to 60 y, with 2 or more components of the metabolic syndrome ( CLINICAL TRIAL REGISTRATION: UMIN000006353). Subjects were randomized to a control group (n=98) that received dietary intervention focused on weight control supervised by registered dietitians, and a dairy-consumption group (n=102) that received both dietary intervention and regular home dairy delivery of 400 g/d for 24 wk. Co-primary endpoints included waist circumference, blood pressure, fasting blood sugar (FBS), and serum lipids. The dietary intervention decreased energy intake from 2,150 to 1,850 kcal/d in both groups (p<0.01). Mean rates of compliance with the dairy-consumption intervention were over 90%, resulting in increased calcium intake in the dairy-consumption group from 329 to 667 mg/d (p<0.01). Co-primary endpoints improved in both groups, but the degree of improvement was smaller in the dairy-consumption group (one-sided p=0.99). Subgroup analyses specified in the study protocol identified weight and leisure-time physical activity (LTPA) as significant effect modifiers. Differences in changes in systolic blood pressure compared with the control group were 28.0 mmHg (95% CI, 214.0 to 21.9, interaction; p<0.01) in the normal weight group and 25.8 mmHg (211.4 to 20.2, interaction; p=0.02) in the moderate-to-high LTPA group, indicating lower systolic blood pressure in the dairy-consumption group among participants in these subgroups. In conclusion, although effects on the co-primary endpoints of dairy consumption were not shown, dairy consumption lowered systolic blood pressure in the subgroups with normal weight and moderate-to-high LTPA and lowered FBS in the subgroup with normal weight. SN - 1881-7742 UR - https://www.unboundmedicine.com/medline/citation/25744418/A_randomized_intervention_trial_of_24_wk_dairy_consumption_on_waist_circumference_blood_pressure_and_fasting_blood_sugar_and_lipids_in_Japanese_men_with_metabolic_syndrome_ L2 - https://dx.doi.org/10.3177/jnsv.60.305 DB - PRIME DP - Unbound Medicine ER -