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Nicotine Attenuates Disruption of Blood-Brain Barrier Induced by Saturated-Fat Feeding in Wild-Type Mice.
Nicotine Tob Res 2015; 17(12):1436-41NT

Abstract

INTRODUCTION

Emerging evidence suggests that integrity of blood-brain barrier (BBB) is pivotal to pathology and pathogenesis of vascular-based neurodegenerative disorders. We have recently reported BBB protective effects of nutraceutical agents with anti-inflammatory properties in an established dietary-induced BBB dysfunction model. Studies also reported that nicotine exhibits anti-oxidative/-inflammatory effects and improve cognitive impairment in Alzheimer's disease. However there has been no studies reporting the effect of nicotine on high-fat-induced BBB dysfunction.

METHODS

In the present study, we investigated the effect of nicotine on BBB integrity and neuro-inflammation in an established mouse model of BBB disruption induced by a diet enriched in saturated fatty acids (SFA).

RESULTS

Wild-type C57BL/6J mice were fed chow enriched in SFA (23% w/w) with/without nicotine for 10 weeks. Compared to mice maintained on SFA-free and low-fat (LF) chow (4% w/w), capillary permeability indicated by the parenchymal extravasation of plasma derived IgG, was significantly greater in the SFA treatment group. Nicotine provided concomitantly with the SFA diet significantly attenuated IgG extravasation, however it remained significantly greater than LF-controls. Markers of neurovascular inflammation glial fibrillary acidic protein, cyclooxygenase-2, and glucose regulated protein 78 remained exaggerated in SFA+nicotine treated mice compared to LF-controls. Nicotine did however modestly, but not significantly, improve plasma total anti-oxidative status in SFA fed mice.

CONCLUSION

Nicotine moderately attenuated BBB disruption induced by chronic ingestion of high-SFA diet, but had no significant effect on neuroinflammation per se.

Authors+Show Affiliations

School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Australia; CHIRI Biosciences Research Precinct, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia; School of Biomedical Sciences, Faculty of Health Sciences, Curtin University, Perth, Australia.School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Australia; CHIRI Biosciences Research Precinct, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia;CHIRI Biosciences Research Precinct, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia;School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Australia; CHIRI Biosciences Research Precinct, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia;School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Australia; CHIRI Biosciences Research Precinct, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia;School of Public Health, Faculty of Health Sciences, Curtin University, Perth, Australia; CHIRI Biosciences Research Precinct, Curtin Health Innovation Research Institute, Curtin University, Perth, Australia; r.takechi@curtin.edu.au.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25744960

Citation

Elahy, Mina, et al. "Nicotine Attenuates Disruption of Blood-Brain Barrier Induced By Saturated-Fat Feeding in Wild-Type Mice." Nicotine & Tobacco Research : Official Journal of the Society for Research On Nicotine and Tobacco, vol. 17, no. 12, 2015, pp. 1436-41.
Elahy M, Lam V, Pallebage-Gamarallage MM, et al. Nicotine Attenuates Disruption of Blood-Brain Barrier Induced by Saturated-Fat Feeding in Wild-Type Mice. Nicotine Tob Res. 2015;17(12):1436-41.
Elahy, M., Lam, V., Pallebage-Gamarallage, M. M., Giles, C., Mamo, J. C., & Takechi, R. (2015). Nicotine Attenuates Disruption of Blood-Brain Barrier Induced by Saturated-Fat Feeding in Wild-Type Mice. Nicotine & Tobacco Research : Official Journal of the Society for Research On Nicotine and Tobacco, 17(12), pp. 1436-41. doi:10.1093/ntr/ntv044.
Elahy M, et al. Nicotine Attenuates Disruption of Blood-Brain Barrier Induced By Saturated-Fat Feeding in Wild-Type Mice. Nicotine Tob Res. 2015;17(12):1436-41. PubMed PMID: 25744960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nicotine Attenuates Disruption of Blood-Brain Barrier Induced by Saturated-Fat Feeding in Wild-Type Mice. AU - Elahy,Mina, AU - Lam,Virginie, AU - Pallebage-Gamarallage,Menuka M, AU - Giles,Corey, AU - Mamo,John C L, AU - Takechi,Ryusuke, Y1 - 2015/03/05/ PY - 2014/10/13/received PY - 2015/02/15/accepted PY - 2015/3/7/entrez PY - 2015/3/7/pubmed PY - 2016/6/23/medline SP - 1436 EP - 41 JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco JO - Nicotine Tob. Res. VL - 17 IS - 12 N2 - INTRODUCTION: Emerging evidence suggests that integrity of blood-brain barrier (BBB) is pivotal to pathology and pathogenesis of vascular-based neurodegenerative disorders. We have recently reported BBB protective effects of nutraceutical agents with anti-inflammatory properties in an established dietary-induced BBB dysfunction model. Studies also reported that nicotine exhibits anti-oxidative/-inflammatory effects and improve cognitive impairment in Alzheimer's disease. However there has been no studies reporting the effect of nicotine on high-fat-induced BBB dysfunction. METHODS: In the present study, we investigated the effect of nicotine on BBB integrity and neuro-inflammation in an established mouse model of BBB disruption induced by a diet enriched in saturated fatty acids (SFA). RESULTS: Wild-type C57BL/6J mice were fed chow enriched in SFA (23% w/w) with/without nicotine for 10 weeks. Compared to mice maintained on SFA-free and low-fat (LF) chow (4% w/w), capillary permeability indicated by the parenchymal extravasation of plasma derived IgG, was significantly greater in the SFA treatment group. Nicotine provided concomitantly with the SFA diet significantly attenuated IgG extravasation, however it remained significantly greater than LF-controls. Markers of neurovascular inflammation glial fibrillary acidic protein, cyclooxygenase-2, and glucose regulated protein 78 remained exaggerated in SFA+nicotine treated mice compared to LF-controls. Nicotine did however modestly, but not significantly, improve plasma total anti-oxidative status in SFA fed mice. CONCLUSION: Nicotine moderately attenuated BBB disruption induced by chronic ingestion of high-SFA diet, but had no significant effect on neuroinflammation per se. SN - 1469-994X UR - https://www.unboundmedicine.com/medline/citation/25744960/Nicotine_Attenuates_Disruption_of_Blood_Brain_Barrier_Induced_by_Saturated_Fat_Feeding_in_Wild_Type_Mice_ L2 - https://academic.oup.com/ntr/article-lookup/doi/10.1093/ntr/ntv044 DB - PRIME DP - Unbound Medicine ER -